المؤلفون: Mark J. Wall, Emily Hill, Robert Huckstepp, Kerry Barkan, Giuseppe Deganutti, Michele Leuenberger, Barbara Preti, Ian Winfield, Sabrina Carvalho, Anna Suchankova, Haifeng Wei, Dewi Safitri, Xianglin Huang, Wendy Imlach, Circe La Mache, Eve Dean, Cherise Hume, Stephanie Hayward, Jess Oliver, Fei-Yue Zhao, David Spanswick, Christopher A. Reynolds, Martin Lochner, Graham Ladds, Bruno G. Frenguelli

المصدر: Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2041-1723Test

الوصول الحر: https://doaj.org/article/248fd0638f5942beb0219612bf9fe670Test

المؤلفون: Barbara Preti, Jean-Sébastien Rougier, Irida Papapostolou, Florian Bochen, Christian E. Gerber, Hugues Abriel, Martin Lochner, Christine Peinelt

المصدر: CHIMIA, Vol 76, Iss 12 (2022)

مصطلحات موضوعية: Cancer, Cardiac disease, TRPM4, Small-molecule inhibitors, Chemistry, QD1-999

وصف الملف: electronic resource

العلاقة: https://chimia.ch/chimia/article/view/6185Test; https://doaj.org/toc/0009-4293Test; https://doaj.org/toc/2673-2424Test

الوصول الحر: https://doaj.org/article/344d922443754d068dbe864dca6661baTest

المؤلفون: Prakash Arullampalam, Barbara Preti, Daniela Ross-Kaschitza, Martin Lochner, Jean-Sébastien Rougier, Hugues Abriel

المصدر: Frontiers in Pharmacology, Vol 12 (2021)

مصطلحات موضوعية: TRP channels, TRPM4, 9-phenanthrol, comparative physiology, mouse models, patch-clamp, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fphar.2021.712354/fullTest; https://doaj.org/toc/1663-9812Test

الوصول الحر: https://doaj.org/article/21cf137dbdef48c6a253499e00e162a1Test

المؤلفون: Giuseppe Deganutti (2609257), Kerry Barkan (7438523), Barbara Preti (10015061), Michele Leuenberger (1399192), Mark Wall (2663167), Bruno G. Frenguelli (407629), Martin Lochner (1269384), Graham Ladds (430368), Christopher A. Reynolds (473093)

مصطلحات موضوعية: Biophysics, Biochemistry, Genetics, Molecular Biology, Pharmacology, Biotechnology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, G i protein complexed state, CPA, structure-based drug design, Agonist Binding Mechanism, binding, GPCR, 1 R, AR, adenosine, G protein-coupled receptors, 1 R agonists

العلاقة: https://figshare.com/articles/journal_contribution/Deciphering_the_Agonist_Binding_Mechanism_to_the_Adenosine_A1_Receptor/13621361Test

الإتاحة: https://doi.org/10.1021/acsptsci.0c00195.s001Test

المؤلفون: Barbara, Preti, Anna, Suchankova, Giuseppe, Deganutti, Michele, Leuenberger, Kerry, Barkan, Iga, Manulak, Xianglin, Huang, Sabrina, Carvalho, Graham, Ladds, Martin, Lochner

المصدر: Journal of medicinal chemistry. 65(21)

مصطلحات موضوعية: Structure-Activity Relationship, Adenosine, Halogens, Purinergic P1 Receptor Agonists, Receptors, Purinergic P1, Animals, Humans, Adenosine-5'-(N-ethylcarboxamide), Rats

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::1fef5ba6c4d64e47165cbcd7955c7afdTest
https://pubmed.ncbi.nlm.nih.gov/36270633Test

المؤلفون: Martin Lochner, Daniela Ross-Kaschitza, Prakash Arullampalam, Hugues Abriel, Barbara Preti, Jean-Sébastien Rougier

المصدر: Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 12 (2021)
Arullampalam, Prakash; Preti, Barbara; Ross, Daniela; Lochner, Martin; Rougier, Jean-Sébastien; Abriel, Hugues (2021). Species-Specific Effects of Cation Channel TRPM4 Small-Molecule Inhibitors. Frontiers in Pharmacology, 12 Frontiers 10.3389/fphar.2021.712354 <http://dx.doi.org/10.3389/fphar.2021.712354Test>

مصطلحات موضوعية: TRPM4, 610 Medicine & health, RM1-950, comparative physiology, Transient receptor potential channel, In vivo, 540 Chemistry, Extracellular, mouse models, Ion channel, Original Research, 9-phenanthrol, Pharmacology, TRP channels, Chemistry, Long-term potentiation, patch-clamp, Small molecule, Cell biology, Electrophysiology, 540 Chemie, 570 Life sciences, biology, Therapeutics. Pharmacology, 610 Medizin und Gesundheit, Intracellular, 570 Biowissenschaften, Biologie

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1362d4f749333e0bbb9118db9ff7348Test
https://doi.org/10.1101/2021.06.01.446517Test

المؤلفون: Barbara Preti, Bruno G. Frenguelli, Christopher A. Reynolds, Martin Lochner, Mark J. Wall, Kerry Barkan, Michele Leuenberger, Graham Ladds, Giuseppe Deganutti

المساهمون: Ladds, Graham [0000-0001-7320-9612], Apollo - University of Cambridge Repository

المصدر: ACS Pharmacol Transl Sci
Deganutti, Giuseppe; Barkan, Kerry; Preti, Barbara; Leuenberger, Michele; Wall, Mark; Frenguelli, Bruno G.; Lochner, Martin; Ladds, Graham; Reynolds, Christopher A. (22 October 2020). Deciphering the Agonist Binding Mechanism to the Adenosine A1 Receptor (bioRxiv). Cold Spring Harbor Laboratory 10.1101/2020.10.22.350827 <http://dx.doi.org/10.1101/2020.10.22.350827Test>

مصطلحات موضوعية: Agonist, binding, medicine.drug_class, Gi alpha subunit, 610 Medicine & health, GPCRs, G protein coupled receptors, Adenosine A1 receptor, mutagenesis experiments, 540 Chemistry, medicine, Pharmacology (medical), SuMD, Receptor, G protein-coupled receptor, Pharmacology, Effector, Chemistry, adenosine A1 receptor, Adenosine receptor, QP, Regadenoson, Cell biology, supervised molecular dynamics, 570 Life sciences, biology, A(1)R, medicine.drug

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18be872306b6a5746378ca500e68e59fTest
https://europepmc.org/articles/PMC7887845Test/

المؤلفون: Mark J, Wall, Emily, Hill, Robert, Huckstepp, Kerry, Barkan, Giuseppe, Deganutti, Michele, Leuenberger, Barbara, Preti, Ian, Winfield, Sabrina, Carvalho, Anna, Suchankova, Haifeng, Wei, Dewi, Safitri, Xianglin, Huang, Wendy, Imlach, Circe, La Mache, Eve, Dean, Cherise, Hume, Stephanie, Hayward, Jess, Oliver, Fei-Yue, Zhao, David, Spanswick, Christopher A, Reynolds, Martin, Lochner, Graham, Ladds, Bruno G, Frenguelli

المصدر: Nature communications. 13(1)

مصطلحات موضوعية: Adenosine, Depression, Receptors, Purinergic P1, Analgesia, Receptors, G-Protein-Coupled

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::6aa941f335f351aaf8baa573ea9efddcTest
https://pubmed.ncbi.nlm.nih.gov/35851064Test