المؤلفون: Ying Zhai, De-Yi Yang, Ernest Asante-Appiah, Lei Chen, Haiqun Tang, Paul Ingravallo, Amin A. Nomeir, John P. Caldwell, Ling Tong, Guowei Zhou, Wensheng Yu, Yueheng Jiang, Oleg Selyutin, Anilkumar G. Nair, Seong Heon Kim, Rong Liu, Joseph A. Kozlowski, Qingbei Zeng, Stuart B. Rosenblum, Michael P. Dwyer, Rong Kong, Ellen Xia, Sony Agrawal, Robert Mazzola, Bandarpalle B. Shankar, Kerry Keertikar

المصدر: Bioorganic & Medicinal Chemistry Letters. 28:1954-1957

مصطلحات موضوعية: 0301 basic medicine, Genotype, Proline, Silylation, viruses, Clinical Biochemistry, Pharmaceutical Science, Hepacivirus, Viral Nonstructural Proteins, Pharmacology, Virus Replication, Antiviral Agents, Heterocyclic Compounds, 4 or More Rings, Biochemistry, 03 medical and health sciences, Dogs, 0302 clinical medicine, Cytochrome P-450 Enzyme System, Pharmacokinetics, Drug Discovery, Animals, Humans, Potency, NS5A, Molecular Biology, Chemistry, Organic Chemistry, virus diseases, Haplorhini, biochemical phenomena, metabolism, and nutrition, digestive system diseases, In vitro, Rats, Regimen, 030104 developmental biology, Molecular Medicine, 030211 gastroenterology & hepatology, Half-Life

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dd2480c8ed858188f3382243eccdd83Test
https://doi.org/10.1016/j.bmcl.2018.03.049Test

المؤلفون: Shiying Chen, Wensheng Yu, Joseph A. Kozlowski, Daniel Lundell, Seong Heon Kim, Ling Tong, Shelby Umland, Xiaoda Niu, Vinay Girijavallabhan, Lei Chen, Aneta Kosinski, Guowei Zhou, Mengwei Hu, Neng-Yang Shih, Bandarpalle B. Shankar, De-Yi Yang

المصدر: Bioorganic & Medicinal Chemistry Letters. 27:3704-3708

مصطلحات موضوعية: 0301 basic medicine, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Hydantoin, ADAM17 Protein, Pharmacology, Biochemistry, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Dogs, Drug Discovery, Animals, Humans, Potency, Prodrugs, Pentanoic Acids, Molecular Biology, Whole blood, chemistry.chemical_classification, Hydantoins, Organic Chemistry, Haplorhini, Prodrug, Tace inhibitor, Rats, Enzyme Activation, 030104 developmental biology, Enzyme, ROC Curve, chemistry, Area Under Curve, Molecular Medicine, Lead compound, Half-Life

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5125137f478242040971d76ea3dc87f8Test
https://doi.org/10.1016/j.bmcl.2017.07.007Test

المؤلفون: Guowei Zhou, Liping Yang, Neng-Yang Shih, M. Arshad Siddiqui, Vinay Girijavallabhan, Shiying Chen, Lei Chen, Dansu Li, Peter Orth, Zhuyan Guo, Bandarpalle B. Shankar, Kristin E. Rosner, Wensheng Yu, Ling Tong, Chaoyang Dai, Joseph A. Kozlowski, Aneta Kosinski, Xiaoda Niu, Seong Heon Kim, Daniel Lundell, Shelby Umland, Janeta Popovici-Muller

المصدر: Bioorganic & Medicinal Chemistry Letters. 27:3037-3042

مصطلحات موضوعية: 0301 basic medicine, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Hydantoin, ADAM17 Protein, Biochemistry, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Dogs, 0302 clinical medicine, Drug Discovery, Animals, Humans, Potency, Protease Inhibitors, Molecular Biology, Whole blood, chemistry.chemical_classification, Chemistry, Hydantoins, Organic Chemistry, Haplorhini, Rats, Enzyme Activation, 030104 developmental biology, Enzyme, ROC Curve, Area Under Curve, Molecular Medicine, Tumor necrosis factor alpha, Half-Life, 030215 immunology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e9ae78bb60384e5c554a062fa84b16eTest
https://doi.org/10.1016/j.bmcl.2017.05.062Test

المؤلفون: Bin Hu, Ling Tong, Sony Agrawal, Craig A. Coburn, Bandarpalle B. Shankar, Michael P. Dwyer, Bin Zhong, Lei Chen, Shiying Chen, Seong Heon Kim, Stuart B. Rosenblum, Shuai Zan, Karin Bystol, Ian W. Davies, Donna Carr, Ernest Asante-Appiah, Wensheng Yu, Joseph A. Kozlowski, Rebecca T. Ruck, Patricia McMonagle, Anilkumar G. Nair, Rong Liu, Oleg Selyutin, De-Yi Yang, Paul Ingravallo, Tao Ji, Qingbei Zeng, Jinglai Hao, Stephanie Curry, Frederick C. Lahser

المصدر: Bioorganicmedicinal chemistry letters. 26(21)

مصطلحات موضوعية: 0301 basic medicine, Indoles, Proline, Stereochemistry, viruses, Clinical Biochemistry, Pharmaceutical Science, Viral Nonstructural Proteins, 01 natural sciences, Biochemistry, Antiviral Agents, 03 medical and health sciences, Structure-Activity Relationship, Drug Discovery, HCV NS5A Inhibitor, Replicon, NS5A, Molecular Biology, Benzofurans, Indole test, Chemistry, Organic Chemistry, Imidazoles, virus diseases, biochemical phenomena, metabolism, and nutrition, digestive system diseases, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 030104 developmental biology, Molecular Medicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a60cb16436bbb67d5e33f8fd3f828fe7Test
https://pubmed.ncbi.nlm.nih.gov/27680588Test

المؤلفون: Guowei Zhou, Ling Tong, Bandarpalle B. Shankar, De-Yi Yang, Rong Liu, Sony Agrawal, Ying Zhai, Rong Kong, Craig A. Coburn, Lei Chen, Qingbei Zeng, Seong Heon Kim, Brian J. Lavey, Kerry Keertikar, Razia Rizvi, Ellen Xia, Michael Wong, Yueheng Jiang, Stuart B. Rosenblum, Wensheng Yu, Ernest Asante-Appiah, Anilkumar G. Nair, Joseph A. Kozlowski, Paul Ingravallo, Amin A. Nomeir, Michael P. Dwyer, Oleg Selyutin

المصدر: Bioorganicmedicinal chemistry letters. 26(16)

مصطلحات موضوعية: 0301 basic medicine, Indoles, Genotype, Hepacivirus, Clinical Biochemistry, Pharmaceutical Science, Viral Nonstructural Proteins, Biochemistry, Antiviral Agents, 03 medical and health sciences, Structure-Activity Relationship, Drug Discovery, Area under curve, Structure–activity relationship, Animals, NS5A, Molecular Biology, Indole test, biology, Chemistry, Organic Chemistry, virus diseases, biology.organism_classification, Virology, digestive system diseases, Rats, 030104 developmental biology, ROC Curve, Area Under Curve, Molecular Medicine, Half-Life

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d95943f585472c6925fcc6867075afb6Test
https://pubmed.ncbi.nlm.nih.gov/27423481Test

المؤلفون: Patricia McMonagle, Sony Agrawal, Stuart B. Rosenblum, Ling Tong, Wensheng Yu, Paul Ingravallo, Bandarpalle B. Shankar, Guowei Zhou, Oleg Selyutin, Razia Rizvi, Bin Zhong, Frederick C. Lahser, Rong Liu, Brian J. Lavey, De-Yi Yang, Stephanie Curry, Craig A. Coburn, Laura Rokosz, Michael P. Dwyer, Joseph A. Kozlowski, Lei Chen, Amin A. Nomeir, Donna Carr, Ernest Asante-Appiah, Yueheng Jiang, Anilkumar G. Nair, Seong Heon Kim, Qingbei Zeng, Jinglai Hao, Michael Wong, Bin Hu

المصدر: Bioorganicmedicinal chemistry letters. 26(15)

مصطلحات موضوعية: 0301 basic medicine, Male, Elbasvir, viruses, Clinical Biochemistry, Pharmaceutical Science, Hepacivirus, Microbial Sensitivity Tests, Pharmacology, Viral Nonstructural Proteins, Virus Replication, 01 natural sciences, Biochemistry, Antiviral Agents, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Drug Discovery, Potency, Structure–activity relationship, Animals, NS5A, Molecular Biology, Benzofurans, Indole test, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Organic Chemistry, Imidazoles, virus diseases, biochemical phenomena, metabolism, and nutrition, Virology, Hepatitis C, digestive system diseases, In vitro, 0104 chemical sciences, Rats, Titer, 030104 developmental biology, chemistry, Aminal, Molecular Medicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d736ae1eea6333cd6ded142d2f518f6Test
https://pubmed.ncbi.nlm.nih.gov/27282742Test

المؤلفون: Ashok Arasappan, Seong-Heon Kim, Robert C. Reynolds, Cheng Li, Aneta Kosinski, Jeremy Clark, Joseph A. Kozlowski, Ling Tong, Vinay Girijavallabhan, Pinto Patrick A, Lei Chen, F. George Njoroge, Anita T. Fowler, Vishal Verma, Subramaniam Ananthan, Randall R. Rossman, Robert Chase, Neng-Yang Shih, Joseph A. Maddry, John A. Secrist, Cecil D. Kwong, Hollis S. Kezar, Abhijit Roychowdhury, Stephanie Curry, Malcolm MacCoss, Hsueh-Cheng Huang, Razia Rizvi, Frank Bennett, Stephen Gavalas, Yuhua Huang, Francisco Velazquez, Alvarez Carmen S, Feng Geng, Xiao Tong, John J. Piwinski, Regina Huelgas, Bandarpalle B. Shankar, Srikanth Venkatraman

المصدر: Bioorganic & Medicinal Chemistry Letters. 22:3229-3234

مصطلحات موضوعية: Pyrimidine, Stereochemistry, Clinical Biochemistry, Substituent, Pharmaceutical Science, Rodentia, Hepacivirus, Virus Replication, Antiviral Agents, Methylation, Biochemistry, Residue (chemistry), chemistry.chemical_compound, Dogs, Species Specificity, In vivo, Drug Discovery, Animals, Potency, Moiety, Benzothiazoles, Replicon, Molecular Biology, Chemistry, Organic Chemistry, Haplorhini, Pyrimidines, Benzothiazole, Molecular Medicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63e593455015b9cae754dc9b1385747bTest
https://doi.org/10.1016/j.bmcl.2012.03.036Test

المؤلفون: Ying Zhai, Ellen Xia, Lei Chen, Bandarpalle B. Shankar, Qingbei Zeng, Anilkumar G. Nair, Sony Agrawal, Ronald N. Buckle, Guowei Zhou, Kannan P. Naicker, John P. Caldwell, Ling Tong, Yueheng Jiang, Stuart B. Rosenblum, Wensheng Yu, Kerry Keertikar, Haiqun Tang, Seong Heon Kim, Rong Liu, De-Yi Yang, Paul Ingravallo, Gregory Scott Martin, Samuel A. Vellekoop, Melissa L. Allard, Christian L. Holst, Michael P. Dwyer, Amin A. Nomeir, Robert Mazzola, Polivina Jolicia F Gauuan, Joseph A. Kozlowski, Oleg Selyutin, Rong Kong

المصدر: Bioorganicmedicinal chemistry letters. 26(5)

مصطلحات موضوعية: 0301 basic medicine, Silylation, Genotype, Proline, viruses, Hepacivirus, Clinical Biochemistry, Pharmaceutical Science, Microbial Sensitivity Tests, Pharmacology, Viral Nonstructural Proteins, Virus Replication, 01 natural sciences, Biochemistry, Antiviral Agents, 03 medical and health sciences, Structure-Activity Relationship, Drug Discovery, Potency, Structure–activity relationship, NS5A, Molecular Biology, biology, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Drug discovery, Organic Chemistry, virus diseases, biochemical phenomena, metabolism, and nutrition, Silanes, biology.organism_classification, digestive system diseases, In vitro, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 030104 developmental biology, Molecular Medicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85586f1ce259c9e4c3146d6078489ecdTest
https://pubmed.ncbi.nlm.nih.gov/26850003Test

المؤلفون: Xiaolian Xu, Seong Heon Kim, Qingbei Zeng, Joseph A. Kozlowski, Carolyn DiIanni Carroll, Neng-Yang Shih, Baldwin John J, Wensheng Yu, Yueheng Jiang, Guizhen Dong, Yuefei Shao, Brian F. Mcguinness, Gopinadhan N. Anilkumar, Lisa Guise Zawacki, Doug W. Hobbs, Chung-Her Jenh, James W. Hall, Stuart B. Rosenblum, Bandarpalle B. Shankar, De-Yi Yang

المصدر: Bioorganic & Medicinal Chemistry Letters. 21:6982-6986

مصطلحات موضوعية: congenital, hereditary, and neonatal diseases and abnormalities, Receptors, CXCR3, Clinical Biochemistry, hERG, Pharmaceutical Science, C-C chemokine receptor type 7, C-C chemokine receptor type 6, CCR5 receptor antagonist, Pharmacology, Biochemistry, Piperazines, Inhibitory Concentration 50, Structure-Activity Relationship, Chemokine receptor, stomatognathic system, Drug Discovery, Animals, Structure–activity relationship, cardiovascular diseases, skin and connective tissue diseases, Molecular Biology, Molecular Structure, biology, Chemistry, Organic Chemistry, Rats, stomatognathic diseases, Pyrazines, biology.protein, Molecular Medicine, Receptor antagonist activity, Protein Binding, CCL21

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c65b7371750c0100d6b469612e6fd2fTest
https://doi.org/10.1016/j.bmcl.2011.09.120Test

المؤلفون: Peter Orth, Bandarpalle B. Shankar, Daniel Lundell, Corey O. Strickland, Vinay Girijavallabhan, Chaoyang Dai, Joseph A. Kozlowski, Janeta Popovici-Muller, Brian J. Lavey, Jing Sun, Shiying Chen, Dansu Li, John J. Piwinski, Razia Rizvi, M. Arshad Siddiqui, Kristin E. Rosner, Lianyun Zhao, Zhuyan Guo, Wong Michael K C, Neng-Yang Shih, Xiaoda Niu

المصدر: Bioorganic & Medicinal Chemistry Letters. 21:3172-3176

مصطلحات موضوعية: Pyrrolidines, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Biological Availability, Pharmaceutical Science, Carboxamide, ADAM17 Protein, Tartrate, Biochemistry, Chemical synthesis, Pyrrolidine, chemistry.chemical_compound, Oral administration, Amide, Drug Discovery, medicine, Animals, Enzyme Inhibitors, Tartrates, Molecular Biology, chemistry.chemical_classification, Molecular Structure, biology, Organic Chemistry, Amides, Rats, Enzyme Activation, ADAM Proteins, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5ffe3fdf02a5dba0580b311b55f7fe2Test
https://doi.org/10.1016/j.bmcl.2011.01.002Test