دورية أكاديمية
أعرض في EDS

Q192R and L55M polymorphisms of paraoxonase 1 gene in chronic myelogenous leukemia and chronic lymphocytic leukemia

التفاصيل البيبلوغرافية
العنوان: Q192R and L55M polymorphisms of paraoxonase 1 gene in chronic myelogenous leukemia and chronic lymphocytic leukemia
المؤلفون: Pehlivan, S., Sahin, H.H., Balci, S.O., Budeyri, S., Pehlivan, M., Tomatir, AyÅŸe Gaye
بيانات النشر: International Institute of Anticancer Research
سنة النشر: 2015
المجموعة: Pamukkale University Repository / Pamukkale Üniversitesi Açık Erişim Arşivi
مصطلحات موضوعية: Humans, Leukemia, Lymphocytic, Chronic, B-Cell, Myelogenous, BCR-ABL Positive, Male, Middle Aged, Polymorphism, Single Nucleotide, Young Adult, genotype, human, major clinical study, polymerase chain reaction, Chronic myeoloid leukemia (CML), Chronic lymphocytic leukemia (CLL), L55M polymorphism, Paraoxonase-1 (PON1), PCR-RFLP, Q192R polymorphism, agarose, aryldialkylphosphatase 1, aryldialkylphosphatase, PON1 protein, adult, aged, allele, Article
الوصف: Aim: The aim of the present study was to investigate the association between Paraoxonase 1 (PON1) gene polymorphisms Q192R, and L55M in patients with Chronic Myelogenous Leukemia (CML) and Chronic Lymphocytic Leukemia (CLL) patients. Materials and Methods: We analyzed samples from 60 patients with CML, 60 with CLL and 84 healthy controls. Polymerase Chain Reaction (PCR) - Restriction Fragment Length Polymorphism (RLFP) was performed and samples were run in agarose gel. Results: We found statistically significant results showing an increase in both the RR genotype (p=0.044) and the R allele (p=0.011) for PON1 Q192R, and an increase in the MM genotype (p=0.007) and a decrease in the LL genotype (p=0.004) and R allele (p=0.001) in PON1 L55M in patients with CLL. Conclusion: We concluded that both the Q192R gene polymorphism with an increase in the genotype R allele, and the M/L55 with an increase in the MM genotype play a role in CLL susceptibility, and a decrease in the LL genotype can act against disease in the Turkish population.
نوع الوثيقة: article in journal/newspaper
اللغة: English
تدمد: 0250-7005
العلاقة: Anticancer Research; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/11499/10478Test; 35; 4807; 4812; 2-s2.0-84939599445; WOS:000359311000029
الإتاحة: https://hdl.handle.net/11499/10478Test
حقوق: none
رقم الانضمام: edsbas.ADF9DFB9
قاعدة البيانات: BASE
الوصف
تدمد:02507005