دورية أكاديمية
Proteomic profiles of peritoneal fluid-derived small extracellular vesicles correlate with patient outcome in ovarian cancer.
| العنوان: | Proteomic profiles of peritoneal fluid-derived small extracellular vesicles correlate with patient outcome in ovarian cancer. |
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| المؤلفون: | Quiralte, Miguel, Barquín, Arantzazu, Yagüe-Fernández, Mónica, Navarro, Paloma, Grazioso, Tatiana P, Sevillano-Fernández, Elena, Rodriguez-Moreno, Juan F, Balarezo-Saldivar, Alejandra, Peinado, Héctor, Izquierdo, Elena, Millán, Carlos, López-Carrasco, Irene, Prieto, Mario, Madurga, Rodrigo, Fernández-Miranda, Ismael, Ruiz-Llorente, Sergio, García-Donas, Jesús |
| المصدر: | J Clin Invest ; ISSN:1558-8238 ; Volume:134 ; Issue:10 |
| بيانات النشر: | American Society for Clinical Investigation |
| سنة النشر: | 2024 |
| المجموعة: | PubMed Central (PMC) |
| مصطلحات موضوعية: | Cancer, Obstetrics/gynecology, Oncology, Proteomics |
| الوصف: | Cancer-derived small extracellular vesicles (sEVs) are capable of modifying the tumor microenvironment and promoting tumor progression. Ovarian cancer (OvCa) is a lethal malignancy that preferentially spreads through the abdominal cavity. Thus, the secretion of such vesicles into the peritoneal fluid could be a determinant factor in the dissemination and behavior of this disease. We designed a prospective observational study to assess the impact of peritoneal fluid-derived sEVs (PFD-sEVs) in OvCa clinical outcome. For this purpose, 2 patient cohorts were enrolled: patients with OvCa who underwent a diagnostic or cytoreductive surgery and nononcological patients, who underwent abdominal surgery for benign gynecological conditions and acted as the control group. Systematic extraction of PFD-sEVs from surgical samples enabled us to observe significant quantitative and qualitative differences associated with cancer diagnosis, disease stage, and platinum chemosensitivity. Proteomic profiling of PFD-sEVs led to the identification of molecular pathways and proteins of interest and to the biological validation of S100A4 and STX5. In addition, unsupervised analysis of PFD-sEV proteomic profiles in high-grade serous ovarian carcinomas (HGSOCs) revealed 2 clusters with different outcomes in terms of overall survival. In conclusion, comprehensive characterization of PFD-sEV content provided a prognostic value with potential implications in HGSOC clinical management. |
| نوع الوثيقة: | article in journal/newspaper report |
| اللغة: | English |
| العلاقة: | https://doi.org/10.1172/JCI176161Test; https://pubmed.ncbi.nlm.nih.gov/38564289Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11093605Test/ |
| DOI: | 10.1172/JCI176161 |
| الإتاحة: | https://doi.org/10.1172/JCI176161Test https://pubmed.ncbi.nlm.nih.gov/38564289Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11093605Test/ |
| رقم الانضمام: | edsbas.1E1F3106 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1172/JCI176161 |
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