التفاصيل البيبلوغرافية
| العنوان: |
Gut dysbiosis is linked to metabolic syndrome in obese Egyptian women: potential treatment by probiotics and high fiber diets regimen. |
| المؤلفون: |
Hassan, Nayera E., El-Masry, Sahar A., El Shebini, Salwa M., Ahmed, Nihad H., Mohamed T, Fouad, Mostafa, Mohammed I., Afify, Mahmoud A. S., Kamal, Ayat N., Badie, Mai M., Hashish, Adel, Alian, Khadija |
| المصدر: |
Scientific Reports; 3/5/2024, Vol. 14 Issue 1, p1-10, 10p |
| مصطلحات موضوعية: |
HIGH-fiber diet, OBESITY in women, EGYPTIANS, METABOLIC syndrome, PROBIOTICS, BASAL metabolism |
| مستخلص: |
Metabolic syndrome (MetS) is defined as a cluster of glucose intolerance, hypertension, dyslipidemia, and central obesity with insulin resistance. The role of gut microbiota in metabolic disorders is increasingly considered. To investigate the effects of probiotic supplements and hypocaloric high fiber regimen on MetS in obese Egyptian women. A longitudinal follow-up intervention study included 58 obese Egyptian women, with a mean age of 41.62 ± 10.70 years. They were grouped according to the criteria of MetS into 2 groups; 23 obese women with MetS and 35 ones without MetS. They followed a hypocaloric high fiber regimen weight loss program, light physical exercise, and received a probiotic supplement daily for 3 months. For each participating woman, blood pressure, anthropometric measurements, basal metabolic rate (BMR), dietary recalls, laboratory investigations, and microbiota analysis were acquired before and after 3 months of follow-up. After intervention by the probiotic and hypocaloric high fiber regimen and light exercise, reduction ranged from numerical to significant difference in the anthropometric parameters, blood pressure, and BMR was reported. All the biochemical parameters characterized by MetS decreased significantly at p ≤ 0.05–0.01. Before the intervention, results revealed abundant of Bacteroidetes bacteria over Firmicutes with a low Firmicutes/Bacteroidetes ratio. After the intervention, Log Lactobacillus, Log Bifidobacteria, and Log Bacteroidetes increased significantly in both groups, while Log Firmicutes and the Firmicutes/Bacteroidetes Ratio revealed a significant decrease. In conclusion, this study's results highlight a positive trend of probiotics supplementation with hypocaloric high-fiber diets in amelioration of the criteria of the Mets in obese Egyptian women. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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