المؤلفون: Cho-Hao Lin, Jimmy Chun-Tien Kuo, Ding Li, Aaron B. Koenig, Alexander Pan, Pearlly Yan, Xue-Feng Bai, Robert J. Lee, Kalpana Ghoshal

المصدر: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

مصطلحات موضوعية: HCC, BRD4 (bromodomain-containing protein 4), AZD5153, NAPRT, ChIP-seq, nanoemulsion, Biology (General), QH301-705.5

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fcell.2022.853652/fullTest; https://doaj.org/toc/2296-634XTest

الوصول الحر: https://doaj.org/article/a6dc99fa367445ea8a02da0162027b18Test

المؤلفون: Xiaofang Xu, Morgan Mann, Dianhua Qiao, Yi Li, Jia Zhou, Allan R. Brasier

المصدر: Frontiers in Molecular Biosciences, Vol 8 (2021)

مصطلحات موضوعية: BRD4, BRD4 (bromodomain-containing protein 4), interferon, ISG (interferon-stimulated genes), MMP-9, Biology (General), QH301-705.5

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fmolb.2021.728661/fullTest; https://doaj.org/toc/2296-889XTest

الوصول الحر: https://doaj.org/article/5154f28d912b4a079eb394d8178b5e67Test

المؤلفون: Ufuk Erdogdu, Nadezda Dolgikh, Stephanie Laszig, Vinzenz Särchen, Michael T. Meister, Marek Wanior, Stefan Knapp, Cathinka Boedicker

المصدر: Neoplasia: An International Journal for Oncology Research, Vol 24, Iss 2, Pp 109-119 (2022)
Neoplasia (New York, N.Y.)
Neoplasia

مصطلحات موضوعية: BH3 mimetics, PBMC, peripheral blood mononuclear cell, Cancer Research, chemical and pharmacologic phenomena, Antineoplastic Agents, Nerve Tissue Proteins, Receptors, Cell Surface, Apoptosis, PI, propidium iodide, BRD4, bromodomain-containing protein 4, MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, Biomimetics, hemic and lymphatic diseases, Cell Line, Tumor, Proto-Oncogene Proteins, Rhabdomyosarcoma, BRD, bromodomain, Humans, BET proteins, RC254-282, Original Research, EV, empty vector, zVAD.fmk, N-benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone, ATCC, American Type Culture Collection, mBCL-2, murine BCL-2, CI, combination index, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, hemic and immune systems, Drug Synergism, BET protein, Bromo- and Extra-Terminal protein, Peptide Fragments, Mitochondria, ERMS, embryonal rhabdomyosarcoma, ARMS, alveolar rhabdomyosarcoma, RMS, rhabdomyosarcoma, FCS, fetal calf serum, biological phenomena, cell phenomena, and immunity

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bbac6aac81f4d40d574992bf92415f7Test
https://doi.org/10.1016/j.neo.2021.11.012Test

المؤلفون: Van der Feen, Diederik E., Kurakula, Kondababu, Tremblay, Eve, Boucherat, Olivier, Bossers, Guido P. L., Szulcek, Robert, Bourgeois, Alice, Lampron, Marie-Claude, Habbout, Karima, Martineau, Sandra, Paulin, Roxane, Kulikowski, Ewelina, Jahagirdar, Ravi, Schalij, Ingrid, Bogaard, Harm Jan, Barteld, Beatrijs, Provencher, Steeve, Berger, Rolf M. F., Bonnet, Sebastien, Goumans, Marie-Jose

المصدر: Van der Feen , D E , Kurakula , K , Tremblay , E , Boucherat , O , Bossers , G P L , Szulcek , R , Bourgeois , A , Lampron , M-C , Habbout , K , Martineau , S , Paulin , R , Kulikowski , E , Jahagirdar , R , Schalij , I , Bogaard , H J , Barteld , B , Provencher , S , Berger , R M F , Bonnet , S & Goumans , M-J 2019 , ' Multicenter Preclinical Validation of BET Inhibition for the Treatment ....

مصطلحات موضوعية: BET inhibition, BRD4 (bromodomain-containing protein 4), pulmonary arterial hypertension, vascular remodeling, right ventricle pressure load, FOXM1, INFLAMMATION, RECEPTOR, CANCER

وصف الملف: application/pdf

العلاقة: https://research.rug.nl/en/publications/94fc4ab0-8fc4-43d8-8a0e-17a2fbdfd0a6Test

الإتاحة: https://doi.org/10.1164/rccm.201812-2275OCTest
https://hdl.handle.net/11370/94fc4ab0-8fc4-43d8-8a0e-17a2fbdfd0a6Test
https://research.rug.nl/en/publications/94fc4ab0-8fc4-43d8-8a0e-17a2fbdfd0a6Test
https://pure.rug.nl/ws/files/248624141/Multicenter_Preclinical_Validation_of_BET_Inhibition_for_the_Treatment_of_Pulmonary_Arterial_Hypertension.pdfTest

المؤلفون: Wenfu Tan, Huaqian Ding, Xiaohua Liu, Chunyong Ding, Juan Wang, Yalei Li, Ao Zhang, Yu Zhang, Hongchun Liu, Wenjing Huang

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 2, Pp 488-504 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: SAR, structure−activity relationship, Hedgehog signaling pathway, BRD4, p.o., per os, medicine.medical_treatment, WNT, wingless, PK, pharmacokinetic, Targeted therapy, BRD4, bromodomain-containing protein 4, 03 medical and health sciences, 0302 clinical medicine, medicine, General Pharmacology, Toxicology and Pharmaceutics, BET, bromo and extra C-terminal bromodomain proteins, Hedgehog, BCC, basal cell carcinoma, 030304 developmental biology, Medulloblastoma, 0303 health sciences, MB, medulloblastoma, TGI, tumor growth inhibition, Oncogene, SHH, Sonic hedgehog, Chemistry, lcsh:RM1-950, medicine.disease, HH, hedgehog, Bromodomain, lcsh:Therapeutics. Pharmacology, Drug resistance, 030220 oncology & carcinogenesis, PTCH, patched, Cancer research, Original Article, i.v., intravenous injection, Smoothened, HTRF, homogeneous time-resolved fluorescence, hERG, human ether-a-go-go-related gene, SMO, smoothened, GLI

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::301cde2b3eb755a22e93dd5c8eb925b1Test
https://doi.org/10.1016/j.apsb.2020.07.007Test

المؤلفون: Cho-Hao Lin, Jimmy Chun-Tien Kuo, Ding Li, Aaron B. Koenig, Alexander Pan, Pearlly Yan, Xue-Feng Bai, Robert J. Lee, Kalpana Ghoshal

مصطلحات موضوعية: Cell Biology, Marine Biology, Cell Development, Proliferation and Death, Cell Metabolism, Cell Neurochemistry, Cellular Interactions (incl. Adhesion, Matrix, Cell Wall), HCC, BRD4 (bromodomain-containing protein 4), AZD5153, NAPRT, ChIP-seq, nanoemulsion

العلاقة: https://figshare.com/articles/dataset/Table3_AZD5153_a_Bivalent_BRD4_Inhibitor_Suppresses_Hepatocarcinogenesis_by_Altering_BRD4_Chromosomal_Landscape_and_Modulating_the_Transcriptome_of_HCC_Cells_XLSX/19409210Test

الإتاحة: https://doi.org/10.3389/fcell.2022.853652.s005Test
https://figshare.com/articles/dataset/Table3_AZD5153_a_Bivalent_BRD4_Inhibitor_Suppresses_Hepatocarcinogenesis_by_Altering_BRD4_Chromosomal_Landscape_and_Modulating_the_Transcriptome_of_HCC_Cells_XLSX/19409210Test

المؤلفون: Cho-Hao Lin, Jimmy Chun-Tien Kuo, Ding Li, Aaron B. Koenig, Alexander Pan, Pearlly Yan, Xue-Feng Bai, Robert J. Lee, Kalpana Ghoshal

مصطلحات موضوعية: Cell Biology, Marine Biology, Cell Development, Proliferation and Death, Cell Metabolism, Cell Neurochemistry, Cellular Interactions (incl. Adhesion, Matrix, Cell Wall), HCC, BRD4 (bromodomain-containing protein 4), AZD5153, NAPRT, ChIP-seq, nanoemulsion

العلاقة: https://figshare.com/articles/figure/Image1_AZD5153_a_Bivalent_BRD4_Inhibitor_Suppresses_Hepatocarcinogenesis_by_Altering_BRD4_Chromosomal_Landscape_and_Modulating_the_Transcriptome_of_HCC_Cells_TIF/19409198Test

الإتاحة: https://doi.org/10.3389/fcell.2022.853652.s001Test
https://figshare.com/articles/figure/Image1_AZD5153_a_Bivalent_BRD4_Inhibitor_Suppresses_Hepatocarcinogenesis_by_Altering_BRD4_Chromosomal_Landscape_and_Modulating_the_Transcriptome_of_HCC_Cells_TIF/19409198Test

المؤلفون: Hiroyuki Mano, Masahito Kawazu, Noboru Mizushima, Kaito Mimura, Jun-Ichi Sakamaki, Hideaki Morishita

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, Purine, Amidophosphoribosyltransferase, mTORC1, tuberous sclerosis complex, Biochemistry, Phosphoribosylformylglycinamidine synthase, chemistry.chemical_compound, BRD4, bromodomain-containing protein 4, LC3, microtubule-associated protein 1 light chain 3, Nucleotide, Clustered Regularly Interspaced Short Palindromic Repeats, DHODH, dihydroorotate dehydrogenase, Purine metabolism, chemistry.chemical_classification, PFAS, phosphoribosylformylglycinamidine synthase, Gene Editing, biology, mTORC1, mammalian target of rapamycin complex 1, nucleotide, nucleoside/nucleotide biosynthesis, Cell biology, Pyrimidine metabolism, Carbon-Nitrogen Ligases with Glutamine as Amide-N-Donor, RHEB, Research Article, Mechanistic Target of Rapamycin Complex 1, MAGeCK, model-based analysis of genome-wide CRISPR-Cas9 knockout, 03 medical and health sciences, HEK, human embryonic kidney, CRISPR/Cas, RHEB, Ras homolog enriched in brain, Autophagy, Humans, GABARAP, γ-aminobutyric acid receptor-associated protein, Molecular Biology, mammalian target of rapamycin, 030102 biochemistry & molecular biology, phosphoribosylformylglycinamidine synthase, CAD, carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase, sgRNA, single guide RNA, Cell Biology, GeCKO, genome-scale CRISPR knockout, 030104 developmental biology, HEK293 Cells, chemistry, biology.protein, nucleoside/nucleotide metabolism, CRISPR-Cas Systems, TSC, tuberous sclerosis complex, PPAT, phosphoribosyl pyrophosphate amidotransferase

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d45dd2cb67d67cf999e1509428d95e52Test
http://europepmc.org/articles/PMC8191307Test

المؤلفون: Felgenhauer, Joshua, Tomino, Laura, Selich-Anderson, Julia, Bopp, Emily, Shah, Nilay

المصدر: Neoplasia (New York, N.Y.)

مصطلحات موضوعية: Original article, Cell Cycle Proteins, Mice, SCID, Fa, fraction affected, Heterocyclic Compounds, 4 or More Rings, AURKA, aurora kinase A, Neuroblastoma, Cell Line, Tumor, Antineoplastic Combined Chemotherapy Protocols, Animals, Humans, LOH, loss of heterozygosity, neoplasms, Aurora Kinase A, N-Myc Proto-Oncogene Protein, CI, combination index, Nuclear Proteins, 11q, long arm of chromosome 11, Drug Synergism, Azepines, Xenograft Model Antitumor Assays, Gene Expression Regulation, Neoplastic, Survival Rate, p-AURKA, phosphorylated AURKA, specifically at threonine 288, Pyrimidines, Vincristine, BRD4, Bromodomain-containing protein 4, Transcription Factors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::cb66eb6c80701d92c4fe65e2f0efe021Test
http://europepmc.org/articles/PMC6111011Test

المؤلفون: Qingqing, Dai, Yuhang, Yan, Xiangli, Ning, Gen, Li, Junlin, Yu, Ji, Deng, Lingling, Yang, Guo-Bo, Li

المصدر: Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: ROC curve, receiver operating characteristic curve, TNKS2, tankyrase 2, Metalloenzyme, HA, hydrogen-bond acceptor, Tryptophan 2,3-dioxygenase, RMSD, root mean square deviation, AUC, area under the curve, BRD4, bromodomain-containing protein 4, CatK, cathepsin K, GA, genetic algorithm, MB, metal coordination, HIV-P, human immunodeficiency virus protease, NDM, new delhi MBL, STK, serine threonine kinase, EX, exclusion volume, Metallo-β-lactamase, IMP, imipenemase, MMP, matrix metalloproteinase, NE, negatively charged center, CA2, carbonic anhydrase 2, AR, aromatic ring, RT, reverse transcriptase, SSEL, secondary structure element length, IDO1, indoleamine 2,3-dioxygenase 1, Original Article, RTK, receptor tyrosine kinase, HD, hydrogen-bond donor, Anchor pharmacophore, CTS, cathepsins, CV, covalent bonding, NP, without anchor pharmacophore features, Virtual screening, Indoleamine 2,3-dioxygenase, MIC, minimum inhibitory concentration, EF, enrichment factor, TDO, tryptophan 2,3-dioxygenase, MAPK14, mitogen-activated protein kinase 14, MBL, metallo-β-lactamase, ROCK1, rho-associated protein kinase 1, VEGFR2, vascular endothelial growth factor receptor 2, VIM, verona integron-encoded MBL, AMPC, asian mouse phenotyping consortium, AP, anchor pharmacophore, SBL, serine beta lactamase, TDSS, torsion-driving systematic search, HIV1-P, human immunodeficiency virus type 1 protease, BACE1, beta-secretase 1, LE, ligand efficiency, CDK2, cyclin-dependent kinase 2, CA, carbonic anhydrase, MMP13, matrix metallopeptidase 13, PO, positively charged center, HY, hydrophobic

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::18c6dc977b69a367b015aaa9f409148bTest
https://pubmed.ncbi.nlm.nih.gov/34386329Test