المؤلفون: Kumaraswamy, Anbarasu, Welker Leng, Katherine, Westbrook, Thomas, Yates, Joel, Zhao, Shuang, Evans, Christopher, Feng, Felix, Morgan, Todd, Alumkal, Joshi

المصدر: European Urology. 80(1)

مصطلحات موضوعية: BET bromodomain, Chromatin, DNA methylation, DNA methyltransferase, Epigenetics, Histone acetyltransferase, Histone deacetylase, Histone demethylase, Histone methyltransferase, Prostate cancer, Ten-Eleven Translocation, Biomarkers, DNA Methylation, Epigenesis, Genetic, Humans, Male, Pharmaceutical Preparations, Prostatic Neoplasms

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/6vs97607Test

المؤلفون: Erin Bradley, Lucia Fusani, Chun-wa Chung, Peter D. Craggs, Emmanuel H. Demont, Philip G. Humphreys, Darren J. Mitchell, Alex Phillipou, Inmaculada Rioja, Rishi R. Shah, Christopher R. Wellaway, Rab K. Prinjha, David S. Palmer, William J. Kerr, Marc Reid, Ian D. Wall, Rosa Cookson

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Genetics, Molecular Biology, Evolutionary Biology, Sociology, Developmental Biology, Inorganic Chemistry, Chemical Sciences not elsewhere classified, structurally differentiated n, quality chemical probes, quality chemical probe, lipophilic efficiency lens, biased benzimidazole series, acetylated histone tails, 300 – 1000, guided growth targeting, bet bromodomain inhibition, guided design, work describes, tandem bromodomains, seminal publications, selective bromodomain, proven invaluable, potential modulation, oncology disease, mediated disruption, key asp, industrial research

العلاقة: https://figshare.com/articles/journal_contribution/Structure-Guided_Design_of_a_Domain-Selective_Bromodomain_and_Extra_Terminal_N_Terminal_Bromodomain_Chemical_Probe/24570415Test

الإتاحة: https://doi.org/10.1021/acs.jmedchem.3c00906.s001Test
https://figshare.com/articles/journal_contribution/Structure-Guided_Design_of_a_Domain-Selective_Bromodomain_and_Extra_Terminal_N_Terminal_Bromodomain_Chemical_Probe/24570415Test

المؤلفون: Jason KK Low, Karishma Patel, Natasha Jones, Paul Solomon, Alexander Norman, Joshua WC Maxwell, Petr Pachl, Jacqueline M Matthews, Richard J Payne, Toby Passioura, Hiroaki Suga, Louise J Walport, Joel P Mackay

مصطلحات موضوعية: Immunology, Biochemistry & Proteomics, Gene Expression, Structural Biology & Biophysics, Cell Biology, Chemical Biology & High Throughput, BET bromodomain, BRD3 structural biology, mRNA display, Walport CC2030, 03 Chemical Sciences, 06 Biological Sciences, 11 Medical and Health Sciences, Biochemistry & Molecular Biology, 31 Biological sciences, 32 Biomedical and clinical sciences, 34 Chemical sciences

العلاقة: https://figshare.com/articles/journal_contribution/mRNA_display_reveals_a_class_of_high-affinity_bromodomain-binding_motifs_that_are_not_found_in_the_human_proteome_/24806118Test

الإتاحة: https://doi.org/10.25418/crick.24806118.v1Test
https://figshare.com/articles/journal_contribution/mRNA_display_reveals_a_class_of_high-affinity_bromodomain-binding_motifs_that_are_not_found_in_the_human_proteome_/24806118Test

المؤلفون: Monika Krošel, Larissa Moser, Miranda Houtman, Jasna Friščić, Matija Tomšič, Oliver Distler, Markus H. Hoffmann, Caroline Ospelt, Kerstin Klein

المصدر: Cells; Volume 12; Issue 8; Pages: 1149

مصطلحات موضوعية: BET bromodomain protein, I-BET, histone acetylation, chromatin organization

وصف الملف: application/pdf

العلاقة: Cellular Immunology; https://dx.doi.org/10.3390/cells12081149Test

الإتاحة: https://doi.org/10.3390/cells12081149Test

المؤلفون: Joshua A. Nord, Sarah L. Wynia-Smith, Alyssa L. Gehant, Rachel A. Jones Lipinski, Aaron Naatz, Inmaculada Rioja, Rab K. Prinjha, John A. Corbett, Brian C. Smith

المصدر: Frontiers in Endocrinology, Vol 13 (2022)

مصطلحات موضوعية: BET bromodomain, BRD4, diabetes, small molecule inhibitor, iNOS, nitric oxide, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fendo.2022.923925/fullTest; https://doaj.org/toc/1664-2392Test

الوصول الحر: https://doaj.org/article/cb05e51596ea4c4db54e368ed7161c17Test

المؤلفون: Elisa Funck-Brentano, Dzeneta Vizlin-Hodzic, Jonas A. Nilsson, Lisa M. Nilsson

المصدر: Epigenetics, Vol 16, Iss 1, Pp 54-63 (2021)

مصطلحات موضوعية: bet bromodomain protein, hexamethylene bisacetamide, glioma, Genetics, QH426-470

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1559-2294Test; https://doaj.org/toc/1559-2308Test

الوصول الحر: https://doaj.org/article/d8a1fde87cbd4cd0a51263ea7e447d9aTest

المؤلفون: Traquete, Rui Miguel Petrucci Albuquerque

المساهمون: Bernardes, Gonçalo José Lopes, Almeida, Sérgio de, Oliveira, Rudi, Repositório da Universidade de Lisboa

مصطلحات موضوعية: Terapêutica cancerígena epigenética, inibidores de proteínas BET, cancro da próstata, entrega seletiva de fármacos, fármacos conjugados, Epigenetic cancer therapy, BET bromodomain inhibitors, prostate cancer, drug delivery, drug conjugates, Domínio/Área Científica::Ciências Médicas::Ciências da Saúde

وصف الملف: application/pdf

الإتاحة: http://hdl.handle.net/10451/57780Test

المؤلفون: Lespinasse, Marie‐ange, Wei, Kaiyao, Perrin, Justine, Winkler, Matthias, Hamaidia, Sieme, Leroy, Alexis, Macek Jilkova, Zuzana, Philouze, Christian, Marche, Patrice, Petosa, Carlo, Govin, Jérôme, Emadali, Anouk, Wong, Yung‐sing

المساهمون: Département de pharmacochimie moléculaire (DPM), Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire CHU Grenoble (CHUGA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Institut de biologie structurale (IBS - UMR 5075), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA), Centre Hospitalier Universitaire CHU Grenoble (CHUGA), Département de Chimie Moléculaire (DCM), Labex Arcane, ANR-17-EURE-0003,CBH-EUR-GS,CBH-EUR-GS(2017), ANR-18-CE18-0007,InhiBET,Développement de nouvelles molécules antifongiques ciblant les protéines BET(2018)

المصدر: ISSN: 0947-6539.

مصطلحات موضوعية: anti-inflammatory agent, za-ortho-quinone methide, BET bromodomain inhibitor, organocatalysis, tetrahydroquinoline, [CHIM.ORGA]Chemical Sciences/Organic chemistry, [CHIM.THER]Chemical Sciences/Medicinal Chemistry

العلاقة: hal-03806738; https://hal.science/hal-03806738Test; https://hal.science/hal-03806738/documentTest; https://hal.science/hal-03806738/file/Manuscript-HAL.pdfTest

الإتاحة: https://doi.org/10.1002/chem.202202293Test
https://hal.science/hal-03806738Test
https://hal.science/hal-03806738/documentTest
https://hal.science/hal-03806738/file/Manuscript-HAL.pdfTest

المؤلفون: Huarui Cui (5858624), Anand Divakaran (2041456), Zachariah J. Hoell (11927725), Mikael O. Ellingson (11927728), Cole R. Scholtz (11927731), Huda Zahid (8823089), Jorden A. Johnson (7147799), Elizabeth C. Griffith (3930155), Clifford T. Gee (4039070), Amani L. Lee (8339832), Shalil Khanal (11927734), Ke Shi (154717), Hideki Aihara (277567), Vijay H. Shah (9972176), Richard E. Lee (284694), Daniel A. Harki (1523884), William C. K. Pomerantz (8053445)

مصطلحات موضوعية: Biophysics, Biochemistry, Genetics, Molecular Biology, Pharmacology, Biotechnology, Evolutionary Biology, Immunology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, unmet goal due, multiple myeloma cells, master transcriptional regulators, high sequence similarity, based design approach, 18 nm affinity, despite brd4 engagement, 30 , 26 , single bromodomain remain, broader bet selectivity, brd4 d1 inhibition, individual bet bromodomain, brd4 d1, fold selectivity, brd4 n, d1 ), brd2 d1

العلاقة: https://figshare.com/articles/journal_contribution/A_Structure-based_Design_Approach_for_Generating_High_Affinity_BRD4_D1-Selective_Chemical_Probes/18130960Test

الإتاحة: https://doi.org/10.1021/acs.jmedchem.1c01779.s002Test

المؤلفون: Cousin, Sophie, Blay, Jean-Yves, Garcia, Irene Brana, de Bono, Johann S., Le Tourneau, Christophe, Moreno, Victor, Trigo, Jose, Hann, Christine L., Azad, Arun A., Im, Seock-Ah, Cassier, Philippe A., French, Christopher A., Italiano, Antoine, Keedy, Vicki L., Plummer, Ruth, Sablin, Marie-Paule, Hemming, Matthew L., Ferron-Brady, Geraldine, Wyce, Anastasia, Khaled, Ahmed, Datta, Antara, Foley, Shawn W., McCabe, Michael T., Wu, Yuehui, Horner, Thierry, Kremer, Brandon E., Dhar, Arindam, O'Dwyer, Peter J., Shapiro, Geoffrey I., Piha-Paul, Sarina A.

المساهمون: 임석아, Im, Seock-Ah

مصطلحات موضوعية: BET BROMODOMAIN PROTEINS, MIDLINE CARCINOMA, BRD-NUT, INHIBITION, FAMILY, DIFFERENTIATION, RECOGNITION, ONCOPROTEIN, EXPRESSION, GUIDELINE, BET inhibitor, castration-resistant prostate cancer, molibresib, NUT carcinoma

العلاقة: International Journal of Cancer, Vol.150 No.6, pp.993-1006; 154174; https://hdl.handle.net/10371/179239Test; 000722710500001; 2-s2.0-85119982365

الإتاحة: https://doi.org/10.1002/ijc.33861Test
https://hdl.handle.net/10371/179239Test