دورية أكاديمية
Reviewing physical exercise in non-obese diabetic Goto-Kakizaki rats
| العنوان: | Reviewing physical exercise in non-obese diabetic Goto-Kakizaki rats |
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| المؤلفون: | B.S.M. Galán, T.D.A. Serdan, L.E. Rodrigues, R. Manoel, R. Gorjão, L.N. Masi, T.C. Pithon-Curi, R. Curi, S.M. Hirabara |
| المصدر: | Brazilian Journal of Medical and Biological Research, Vol 55 (2022) |
| بيانات النشر: | Associação Brasileira de Divulgação Científica, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine (General) LCC:Biology (General) |
| مصطلحات موضوعية: | Exercise intensity, Insulin resistance, Glycemic control, Type 2 diabetes mellitus, Skeletal muscle, Metabolism, Medicine (General), R5-920, Biology (General), QH301-705.5 |
| الوصف: | There is a high incidence of non-obese type 2 diabetes mellitus (non-obese-T2DM) cases, particularly in Asian countries, for which the pathogenesis remains mainly unclear. Interestingly, Goto-Kakizaki (GK) rats spontaneously develop insulin resistance (IR) and non-obese-T2DM, making them a lean diabetes model. Physical exercise is a non-pharmacological therapeutic approach to reduce adipose tissue mass, improving peripheral IR, glycemic control, and quality of life in obese animals or humans with T2DM. In this narrative review, we selected and analyzed the published literature on the effects of physical exercise on the metabolic features associated with non-obese-T2DM. Only randomized controlled trials with regular physical exercise training, freely executed physical activity, or skeletal muscle stimulation protocols in GK rats published after 2008 were included. The results indicated that exercise reduces plasma insulin levels, increases skeletal muscle glycogen content, improves exercise tolerance, protects renal and myocardial function, and enhances blood oxygen flow in GK rats. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1414-431X 1414-431x |
| العلاقة: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2022000100304&tlng=enTest; https://doaj.org/toc/1414-431XTest |
| DOI: | 10.1590/1414-431x2022e11795 |
| الوصول الحر: | https://doaj.org/article/bb5428093760420ebf47eb5226bd8cebTest |
| رقم الانضمام: | edsdoj.bb5428093760420ebf47eb5226bd8ceb |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 1414431X 1414431x |
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| DOI: | 10.1590/1414-431x2022e11795 |