The long-term renal and retinal outcome of childhood-onset Type 1 diabetes
| العنوان: | The long-term renal and retinal outcome of childhood-onset Type 1 diabetes |
|---|---|
| المؤلفون: | B. Allagoa, J. N. Harvey |
| المصدر: | Diabetic Medicine. 21:26-31 |
| بيانات النشر: | Wiley, 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Pediatrics, Time Factors, Adolescent, Endocrinology, Diabetes and Metabolism, Population, Nephropathy, Diabetic nephropathy, Sex Factors, Endocrinology, Risk Factors, Diabetes mellitus, Internal Medicine, Albuminuria, Humans, Medicine, Diabetic Nephropathies, Age of Onset, Child, education, Retrospective Studies, Type 1 diabetes, education.field_of_study, Diabetic Retinopathy, business.industry, Infant, Odds ratio, Prognosis, medicine.disease, Survival Analysis, Surgery, Proteinuria, Diabetes Mellitus, Type 1, Child, Preschool, Relative risk, Female, Microalbuminuria, business |
| الوصف: | Aims To quantify the influence of childhood onset on long-term renal and retinal outcome in Type 1 diabetes. Methods We used a population-based diabetes register to identify all Type 1 patients diagnosed before age 15 from 1960 to 1982 and resident in a defined catchment area in 1999. Those diagnosed before age 5, aged 5–9 and 10–14 years were compared with a reference group diagnosed at age 21–25 years over the same period. Results Compared with adult-onset controls, proteinuria occurred earlier (P = 0.02) and nephropathy outcome was worse (P = 0.008) in childhood-onset diabetes. The risk of developing microalbuminuria was greater in childhood-onset diabetes: odds ratio 2.6 (95% confidence interval 1.4–4.9, P = 0.003). The relative risk of established nephropathy was 3.8 (1.5–9.4, P = 0.005) with childhood onset. The number developing background retinopathy did not differ with age at onset but younger onset patients were more likely to need laser treatment: relative risk 2.1 (1.1–3.8, P = 0.02). This maintained visual outcome which was not significantly different between the various age at onset groups. Conclusions Patients with onset of Type 1 diabetes before age 15 have substantially worse renal outcome and require more laser treatment than adult-onset patients. Differences between those with onset before age 5, onset at 5–9 and 10–14 years are small compared with the difference between childhood onset and adult onset. Events in the teenage years therefore appear to have a major adverse effect on the risk of developing long-term microvascular complications. |
| تدمد: | 1464-5491 0742-3071 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f27478d72baea91ffde60afd913382fTest https://doi.org/10.1046/j.1464-5491.2003.01062.xTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....3f27478d72baea91ffde60afd913382f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14645491 07423071 |
|---|