دورية أكاديمية
Increased extrafollicular expression of the B-cell stimulatory molecule CD70 in HIV-1-infected individuals
| العنوان: | Increased extrafollicular expression of the B-cell stimulatory molecule CD70 in HIV-1-infected individuals |
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| المؤلفون: | Lantto, R., Nasi, A., Sammicheli, S., Amu, S., Fievez, V., Moutschen, Michel, Pensieroso, S., Hejdeman, B., Chiodi, F., Rethi, B. |
| المصدر: | AIDS, 29 (14), 1757-1766 (2015) |
| بيانات النشر: | Lippincott Williams and Wilkins |
| سنة النشر: | 2015 |
| المجموعة: | University of Liège: ORBi (Open Repository and Bibliography) |
| مصطلحات موضوعية: | B-cell hyperactivation, B-cell turnover, CD4+ T-cell lymphopenia, CD70, T-cell activation, CD38 antigen, CD4 antigen, CD70 antigen, Fas antigen, Ki 67 antigen, LAIR1 protein, CD70 protein, human, Human immunodeficiency virus antibody, Article, B lymphocyte activation, CD4+ T lymphocyte, Human immunodeficiency virus 1 infection, Human immunodeficiency virus infected patient, Th1 cell, B lymphocyte, Human immunodeficiency virus 1, Human immunodeficiency virus infection, SCID mouse, Adult, Animals, Antigens, Surface, B-Lymphocytes, CD4-Positive T-Lymphocytes |
| الوصف: | peer reviewed ; Objective: CD70 molecules expressed by activated T cells provide potent B cell stimulatory signals. We hypothesized that an altered CD70 expression might contribute to B cell abnormalities during HIV-1 infection. Design: CD70 expression and the functional and migratory properties of the CD4+CD70+ T lymphocytes were analyzed in HIV-1-infected patients and in humanized mice. Correlations were tested between CD70 expression and features of B-cell activation, apoptosis sensitivity and functional exhaustion. Methods: CD4+CD70+ T cells were analyzed in cohorts of CD4+ T-cell lymphopenic, viremic or nonlymphopenic, nonviremic HIV-1-infected patients and in noninfected individuals. CD70 upregulation was also followed in HIV-1-infected humanized mice. CD38, CD95, LAIR1 and PD-1 expressions were monitored on B-cell subpopulations, Ki67 was assessed to estimate B-cell proliferation and antibody levels were measured in plasma. Results: Blood CD4+CD70+ T-cell frequencies increased in response to CD4+ T-cell depletion or high viremia levels as a possible consequence of increased activation and proliferation in this subset. CD4+CD70+ T cells produced T-helper 1-type cytokines and expressed chemokine receptors mobilizing toward sites of inflammation but not to lymphoid follicles. High CD70 expression was observed in HIV-1-infected humanized mice at extrafollicular sites (peritoneum, bone-marrow). CD4+CD70+ T-cell frequencies correlated with the expression of the activation marker CD38 and the death receptor CD95 on various memory B-cell subsets, with B-cell proliferation and with plasma IgG levels. Conclusions: CD4+CD70+ T cells may contribute to B cell hyperactivation and accelerated memory B-cell turnover during HIV-1 infection. © Copyright 2015 Wolters Kluwer Health, Inc. All rights reserved. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0269-9370 1473-5571 |
| العلاقة: | urn:issn:0269-9370; urn:issn:1473-5571; https://orbi.uliege.be/handle/2268/233449Test; info:hdl:2268/233449; scopus-id:2-s2.0-84975142420; info:pmid:26262581 |
| DOI: | 10.1097/QAD.0000000000000779 |
| الإتاحة: | https://doi.org/10.1097/QAD.0000000000000779Test https://orbi.uliege.be/handle/2268/233449Test |
| حقوق: | restricted access ; http://purl.org/coar/access_right/c_16ecTest ; info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.A2E977CE |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 02699370 14735571 |
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| DOI: | 10.1097/QAD.0000000000000779 |