دورية أكاديمية
Detection of transient abnormal myelopoiesis blasts in a liver biopsy specimen by double-immunostaining for full-length GATA1 and CD42b
| العنوان: | Detection of transient abnormal myelopoiesis blasts in a liver biopsy specimen by double-immunostaining for full-length GATA1 and CD42b |
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| المؤلفون: | Azusa Haba, Yuko Imaizumi, Daichi Hayashi, Shiho Yasue, Hiroki Otsuka, Saori Endo, Michio Ozeki, Kazuhiro Kobayashi, Tatsuhiko Miyazaki, Akira Hara, Hidenori Ohnishi |
| المصدر: | Hematology, Vol 28, Iss 1 (2023) |
| بيانات النشر: | Taylor & Francis Group, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Diseases of the blood and blood-forming organs |
| مصطلحات موضوعية: | Down syndrome, GATA-binding factor 1, Liver fibrosis, Transient leukemia of Down syndrome, Transient myeloproliferative disorder, Diseases of the blood and blood-forming organs, RC633-647.5 |
| الوصف: | ABSTRACTBackground Transient abnormal myelopoiesis (TAM) is characterized by leukocytosis with increased circulating megakaryoblasts that harbor N-terminal truncating mutations in the GATA1 gene. Approximately 10% of affected patients experience early death.Observations A 2-month-old boy with Down syndrome was diagnosed with TAM and followed without treatment. Although the blasts in the peripheral blood disappeared, liver failure progressed. A pathological examination revealed liver fibrosis, and double-immunostaining for full-length GATA1 and CD42b identified megakaryocytes with a GATA1 mutation.Conclusions This simple and cost-effective method can be applied in routine practice to detect TAM blasts during assessment in a TAM crisis. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 16078454 1607-8454 |
| العلاقة: | https://doaj.org/toc/1607-8454Test |
| DOI: | 10.1080/16078454.2023.2240135 |
| الوصول الحر: | https://doaj.org/article/d41750bc1a3346248b64fb0dc059783bTest |
| رقم الانضمام: | edsdoj.41750bc1a3346248b64fb0dc059783b |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 16078454 |
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| DOI: | 10.1080/16078454.2023.2240135 |