المؤلفون: Fondazione Policlinico Universitario Campus Bio-Medico, IRCCS National Neurological Institute "C. Mondino" Foundation, Società italiana per lo studio delle Cefalee (SISC), Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari, Università degli Studi dell'Aquila, University of Roma La Sapienza, Azienda Ospedaliero Universitaria Policlinico Modena, Euganea Health Unit, Padua, Italy, Azienda Ospedaliero-Universitaria di Parma, Azienda Ospedaliera S. Maria della Misericordia, Azienda Ospedaliera Città della Salute e della Scienza di Torino, Cliniche Humanitas Gavazzeni, University of Campania "Luigi Vanvitelli", Ospedale di Prato, Azienda Policlinico Umberto I, Auxologico San Luca, Milano, ASST Spedali Civili, Brescia

المساهمون: Luigi Francesco Iannone, Researcher at the Headache Center and Clinical Pharmacology Unit and at the Department of Health Sciences, University of Florence, Principal Investigator

المصدر: Pozo-Rosh P, AanJ, Asha M, Goadsby PJ, Lton RB, Reuter U, Guo H, Schwefel B, Lu K, Bopally R, MelR, De Abreu Ferrea R, McCusker E, Yu SY, Severt L, Fnegan M, Trugman JM. Atogepant for the prevente treatment of chron mrae (PROGRESS): a randomed, double-bld, placebo-controlled, phase 3 trl. Lancet. 2023 Sep 2;402(10404):775-785. do 10.1016/S0140-6736(23)01049-8. Epub 2023 Jul 26. Erratum : Lancet. 2023 Sep 2;402(10404):774. Lancet. 2023 Oct 14;402(10410):1328.
Goadsby PJ, Dodk DW, AanJ, Trugman JM, Fnegan M, Lu K, SzegedA. Safety, toleraby, and effacy of orally admtered atogepant for the preventn of epod mrae adults: a double-bld, randomed phase 2b/3 trl. Lancet Neurol. 2020 Sep;19(9):727-737. do 10.1016/S1474-4422(20)30234-9. Erratum : Lancet Neurol. 2020 Nov;19(11):e10.
Schwedt TJ, Lton RB, AanJ, Sberste SD, TassorellC, Guo H, Lu K, Dabruzzo B, MelR, Severt L, Fnegan M, Trugman JM. Te course of effacy of atogepant for the prevente treatment of mrae: Results from the randomed, double-bld ADVANCE trl. Cephalalg. 2022 Jan;42(1):3-11. do 10.1177/03331024211042385. Epub 2021 Sep 14.
TassorellC, Nagy K, Pozo-Rosh P, LanterMet M, Sacco S, Nezadal T, Guo H, De Abreu Ferrea R, Forero G, Trugman JM. Safety and effacy of atogepant for the prevente treatment of epod mrae adults for whom conventnal oral prevente treatments have faed (ELEVATE): a randomed, placebo-controlled, phase 3b trl. Lancet Neurol. 2024 Apr;23(4):382-392. do 10.1016/S1474-4422(24)00025-5. Epub 2024 Feb 13.
STudio Osservazionale Sull'Efficacia, Sicurezza e tollerabilità di Atogepant in Pazienti Real Life Affetti da Emicrania in Italia (Studio STAR)

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT06414044Test

المؤلفون: Azienda Ospedaliero Universitaria Policlinico Modena, Società italiana per lo studio delle Cefalee (SISC), IRCCS National Neurological Institute "C. Mondino" Foundation, Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari, Università degli Studi dell'Aquila, University of Roma La Sapienza, Euganea Health Unit, Padua, Italy, Azienda Ospedaliero-Universitaria di Parma, Azienda Ospedaliera S. Maria della Misericordia, Azienda Ospedaliera Città della Salute e della Scienza di Torino, Cliniche Humanitas Gavazzeni, University of Campania "Luigi Vanvitelli", Ospedale di Prato, Azienda Policlinico Umberto I, Auxologico San Luca, Milano, ASST Spedali Civili, Brescia, Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta

المساهمون: Luigi Francesco Iannone, Researcher at the Headache Center and Clinical Pharmacology Unit and the Department of Health Sciences, University of Florence, Principal Investigator

المصدر: Dodk DW, Lton RB, Sberste S, Goadsby PJ, BndD, Hman J, Cady R, Smh J. Eptezumab for preventn of chron mrae: A randomed phase 2b clal trl. Cephalalg. 2019 Aug;39(9):1075-1085. do 10.1177/0333102419858355. Epub 2019 Jun 24.
Wner PK, McAllter P, Chakhava G, AanJ, Ettrup A, Krog Josssen M, Ldsten A, Mehta L, Cady R. Effects of travenous Eptezumab vs Placebo on Headache Pa and Most Bothersome Symptom When ted Durg a Mrae Attack: A Randomed Clal Trl. JAMA. 2021 Jun 15;325(23):2348-2356. do 10.1001/jama.2021.7665.
Asha M, LanterMet M, Pozo-Rosh P, Ettrup A, Chrtoffersen CL, Josssen MK, Phul R, Sperlg B. Safety and effacy of eptezumab for mrae preventn patnts wh two-to-four prevus prevente treatment faures (DELER): a multarm, randomed, double-bld, placebo-controlled, phase 3b trl. Lancet Neurol. 2022 Jul;21(7):597-607. do 10.1016/S1474-4422(22)00185-5.
Effectiveness and Tolerability of Eptinezumab: a Prospective, Multicentric, Cohort Study

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT06409845Test

المؤلفون: IRCCS National Neurological Institute "C. Mondino" Foundation, Società italiana per lo studio delle Cefalee (SISC), Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari, Università degli Studi dell'Aquila, University of Roma La Sapienza, Azienda Ospedaliero Universitaria Policlinico Modena, Ospedale di Piove di Sacco, Azienda Ospedaliero-Universitaria di Parma, Azienda Ospedaliera S. Maria della Misericordia, Azienda Ospedaliera Città della Salute e della Scienza di Torino, Cliniche Humanitas Gavazzeni, University of Campania "Luigi Vanvitelli", Ospedale di Prato, Azienda Policlinico Umberto I, Auxologico San Luca, Milano, ASST Spedali Civili, Brescia, Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta

المساهمون: Luigi Francesco Iannone, Researcher at the Headache Center and Clinical Pharmacology Unit and the Department of Health Sciences, University of Florence, Principal Investigator

المصدر: Lton RB, Croop R, Stock EG, Stock DA, Morr BA, Frost M, Dubowch GM, Conway CM, Cor V, Goadsby PJ. Regepant, an Oral Calcon Gene-Related Pepte Receptor Antagont, for Mrae. N Engl J Med. 2019 Jul 11;381(2):142-149. do 10.1056/NEJMoa1811090.
Croop R, Lton RB, Kudrow D, Stock DA, Kamen L, Conway CM, Stock EG, Cor V, Goadsby PJ. Oral regepant for prevente treatment of mrae: a phase 2/3, randomed, double-bld, placebo-controlled trl. Lancet. 2021 Jan 2;397(10268):51-60. do 10.1016/S0140-6736(20)32544-7. Epub 2020 Dec 15.
RimegepAnt effectIvenesS and tolErability as Migraine Preventive Treatment: a Prospective, Multicentric, Cohort Study (RAISE)

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT06409832Test

المؤلفون: Fondazione C.N.R./Regione Toscana "G. Monasterio", Pisa, Italy, Centro Cardiologico Monzino, A.O. Ospedale Papa Giovanni XXIII, IRCCS Ospedale San Raffaele, Azienda Ospedaliera Universitaria Senese, IRCCS Humanitas, Rozzano, Ospedale Policlinico San Martino, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Fondazione IRCCS Policlinico San Matteo di Pavia, Ospedali Riuniti di Foggia, Azienda Ospedaliera Città della Salute e della Scienza di Torino, ASU Giuliano Isontina, Trieste, Azienda Ospedaliera S. Maria della Misericordia, IRCCS Policlinico S. Donato, ASST Santi Paolo e Carlo

المساهمون: Marco METRA, Marco Metra

المصدر: OPTImal PHARMacological Therapy for Patients With Heart Failure: The OPTIPHARM-HF Registry

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT06192524Test

المؤلفون: IRCCS National Neurological Institute "C. Mondino" Foundation, Società italiana per lo studio delle Cefalee (SISC), Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari, Università degli Studi dell'Aquila, University of Roma La Sapienza, Azienda Ospedaliero Universitaria Policlinico Modena, Ospedale di Piove di Sacco, Azienda Ospedaliero-Universitaria di Parma, Azienda Ospedaliera S. Maria della Misericordia, Azienda Ospedaliera Città della Salute e della Scienza di Torino, Cliniche Humanitas Gavazzeni, University of Campania "Luigi Vanvitelli", Ospedale di Prato, Azienda Policlinico Umberto I, Auxologico San Luca, Milano, ASST Spedali Civili, Brescia, Carlo Besta Neurological Institute

المساهمون: Luigi Francesco Iannone, Researcher

المصدر: Asha M, Reuter U, Smh T, Krke-Workel J, Kle SR, Bragg S, Doty EG, Dowsett SA, L Q, Krege JH. Randomed, controlled trl of lasman over four mrae attacks: Fdgs from the CENTURN study. Cephalalg. 2021 Mar;41(3):294-304. do 10.1177/0333102421989232. Epub 2021 Feb 4.
Goadsby PJ, Wtecha LA, Dennehy EB, Kuca B, Case MG, Aurora SK, Gaul C. Phase 3 randomed, placebo-controlled, double-bld study of lasman for acute treatment of mrae. Bra. 2019 Jul 1;142(7):1894-1904. do 10.1093/bra/awz134.
Effectiveness and Tolerability of Lasmiditan as Acute Migraine Treatment: a Prospective, Multicentric, Cohort Study

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT05903040Test

المؤلفون: IRCCS National Neurological Institute "C. Mondino" Foundation, Società italiana per lo studio delle Cefalee (SISC), Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari, Università degli Studi dell'Aquila, University of Roma La Sapienza, Azienda Ospedaliero Universitaria Policlinico Modena, Ospedale di Piove di Sacco, Azienda Ospedaliero-Universitaria di Parma, Azienda Ospedaliera S. Maria della Misericordia, Azienda Ospedaliera Città della Salute e della Scienza di Torino, Cliniche Humanitas Gavazzeni, University of Campania "Luigi Vanvitelli", Ospedale di Prato, Azienda Policlinico Umberto I, Auxologico San Luca, Milano, ASST Spedali Civili, Brescia, Carlo Besta Neurological Institute

المساهمون: Luigi Francesco Iannone, Researcher

المصدر: Lton RB, Croop R, Stock EG, Stock DA, Morr BA, Frost M, Dubowch GM, Conway CM, Cor V, Goadsby PJ. Regepant, an Oral Calcon Gene-Related Pepte Receptor Antagont, for Mrae. N Engl J Med. 2019 Jul 11;381(2):142-149. do 10.1056/NEJMoa1811090.
Croop R, Goadsby PJ, Stock DA, Conway CM, Forshaw M, Stock EG, Cor V, Lton RB. Effacy, safety, and toleraby of regepant orally dtegratg tablet for the acute treatment of mrae: a randomed, phase 3, double-bld, placebo-controlled trl. Lancet. 2019 Aug 31;394(10200):737-745. do 10.1016/S0140-6736(19)31606-X. Epub 2019 Jul 13.
Lton RB, Blumenfeld A, Jensen CM, Croop R, Thy A, L'aln G, Morr BA, Cor V, Goadsby PJ. Effacy of regepant for the acute treatment of mrae based on trtan treatment expernce: Pooled results from three phase 3 randomed clal trls. Cephalalg. 2023 Feb;43(2):3331024221141686. do 10.1177/03331024221141686.
Effectiveness and Tolerability of Rimegepant as Acute Migraine Treatment: a Prospective, Multicentric, Cohort Study (GAINER)

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT05903027Test

المؤلفون: Politecnico di Milano, Ospedale Policlinico San Martino, Insieme per i Pazienti di Oncologia Polmonare Onlus (IPOP), ASST Grande Ospedale Metropolitano Niguarda, University of Campania "Luigi Vanvitelli", Azienda Ospedaliera dei Colli, Fondazione IRCCS Policlinico San Matteo di Pavia, Azienda Ospedaliera S. Maria della Misericordia, Azienda Ospedaliera "Sant'Andrea", Azienda Ospedaliero Universitaria, Santa Maria della Misericordia di Udine, Italy, IRCCS Sacro Cuore Don Calabria di Negrar, Azienda Ospedaliero, Universitaria Ospedali Riuniti, Istituto Clinico Humanitas, Azienda Unità Sanitaria Locale della Romagna, Istituti Ospitalieri di Cremona

المساهمون: Arsela Prelaj, Principal Investigator

المصدر: APOLLO 11, Consortium of Italian Centers Involved in Treatment of Patients With Lung Cancer Treated With Innovative Therapies: Real World Data and Translational Reaserch

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT05550961Test

Other URLs: https://www.associazione-ipop.org/progetto-apollo11Test/

المؤلفون: Cardarelli Hospital, Fondazione C.N.R./Regione Toscana "G. Monasterio", Pisa, Italy, Monaldi Hospital, Federico II University, Cava de Tirreni Costiera Amalfitana Hospital Salerno, Umberto I Hospital, Nocera Inferiore, Azienda Ospedaliera OO.RR. S. Giovanni di Dio e Ruggi D'Aragona, Azienda Ospedaliera S. Maria della Misericordia, University of Pisa, Niguarda Hospital, IRCCS Policlinico S. Donato, University of Parma, University of Siena, Foligno Hospital, University of Targu Mures, Romania, Szeged University, National Cardiology Hospital, Bulgaria, Bieganski Hospital Lodz, Poland, Departement of clinical sciences, Lund University and Skane University Hospidal, Lund Sweden, king Faisal Hospital Riyad, Saudi Arabia, Piedmont Heart Institute, Inc., Atlanta, GA, Jewish General Hospital, Ospedali Riuniti di Foggia

المساهمون: Stefano Ghio, MD

المصدر: Echocardiographic Assessment and CLInical imPlication of Functional tricuSpid rEgurgitation in Heart Failure With Reduced or Preserved Ejection Fraction (ECLIPSE-HF)

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT05209919Test

المؤلفون: Ospedale Umberto I di Torino, A.O.U. Città della Salute e della Scienza - Molinette Hospital, Ospedale Cardinal Massaia, Azienda Ospedaliero Universitaria Maggiore della Carita, Azienda Ospedaliera S. Maria della Misericordia, IRCCS Multimedica, San Giovanni di Dio Hospital, Monaldi Hospital, Ospedale Miulli, Acquaviva delle Fonti, Ospedale San Bortolo di Vicenza, The Mediterranean Institute for Transplantation and Advanced Specialized Therapies, ASST Fatebenefratelli Sacco, Ospedale Policlinico San Martino, Azienda Ospedaliera Bolognini di Seriate Bergamo, Federico II University, Ospedale Santa Croce-Carle Cuneo, Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria, Martini Hospital, Turin, Italy, Ospedale di Ariano Irpino, Ospedale di Borgomanero, ASL Verbano Cusio Ossola, Policlinico Hospital, Azienda Ospedaliero Universitaria di Cagliari, Fatebenefratelli Hospital, Centro Cuore Morgagni, Pedara, Santa Maria delle Grazie Hospital, Ospedale di Gorizia, ASP Enna, Ospedale Garibaldi, Catania, Ospedali Riuniti Anzio-Nettuno, Ospedale Fracastoro, Soave San Bonifacio, Ospedale Magalini, Villafranca, Casa di Cura Pierangeli, Pescara

المساهمون: Mario Matta, M.D.

المصدر: Borggrefe MM, Lawo T, Butter C, Schmger H, LunatM, Pske B, Mr AR, Curn A, Bocker D, Rempp A, Kautzner J, Stuhlger M, Leclerq C, Taborsky M, Frer M, Pares M, Burkhoff D, Hdrks G. Randomed, double bld study of non-excatory, cardc contracty modulatn electral pulses for symptomat heart faure. Eur Heart J. 2008 Apr;29(8):1019-28. do 10.1093/eurheartj/ehn020. Epub 2008 Feb 12.
Kuck KH, Bordachar P, Borggrefe M, BornG, BurrH, Leyva F, Schauerte P, Theuns D, Thault B; Document Revwers; Kchhof P, Hasenfuss G, Dkste K, Leclercq C, Lde C, TavazzL, Ruschzka F. New deves heart faure: an European Heart Rhythm Assoctn report: developed by the European Heart Rhythm Assoctn; endorsed by the Heart Faure Assoctn. Europace. 2014 Jan;16(1):109-28. do 10.1093/europace/eut311. Epub 2013 Nov 20.
Abraham WT, Kuck KH, Goldsmh RL, Ldenfeld J, Reddy VY, Carson PE, Mann DL, Savle B, Pare H, Chan R, Wgn P, Hastgs JL, Kaplan AJ, Edelmann F, Luthje L, Kahwash R, TomassonGF, Gutterman DD, Stagg A, Burkhoff D, Hasenfuss G. A Randomed Controlled Trl to Evaluate the Safety and Effacy of Cardc Contracty Modulatn. JACC Heart Fa. 2018 Oct;6(10):874-883. do 10.1016/j.jchf.2018.04.010. Epub 2018 May 10. Erratum : JACC Heart Fa. 2023 Jan;11(1):132.
Kloppe A, Lawo T, M D, Schdat F, Muegge A, Lemke B. Long-term surval wh Cardc Contracty Modulatn patnts wh NYHA or symptoms and normal QRS duratn. t J Cardl. 2016 Apr 15;209:291-5. do 10.1016/j.card.2016.02.001. Epub 2016 Feb 3.
Kuschyk J, Roeger S, Schneer R, Strener F, Stach K, Rud B, Wes C, Schpf R, Papavasl T, Rousso B, Burkhoff D, Borggrefe M. Effacy and surval patnts wh cardc contracty modulatn: long-term sgle center expernce 81 patnts. t J Cardl. 2015 Mar 15;183:76-81. do 10.1016/j.card.2014.12.178. Epub 2015 Jan 20.
Butter C, RastogS, Mden HH, Meyhofer J, Burkhoff D, Sabbah HN. Cardc contracty modulatn electral snals prove myocardl gene expressn patnts wh heart faure. J Am Coll Cardl. 2008 May 6;51(18):1784-9. do 10.1016/j.jacc.2008.01.036.
aM, RastogS, Gupta RC, Mhra S, Sharov VG, Stanley WC, Ma Y, Rousso B, Burkhoff D, Ben-Ha S, Sabbah HN. Therapy wh cardc contracty modulatn electral snals proves left ventrular functn and remodelg dogs wh chron heart faure. J Am Coll Cardl. 2007 May 29;49(21):2120-8. do 10.1016/j.jacc.2006.10.082. Epub 2007 May 17.
Anker SD, Borggrefe M, Neuser H, Ohlow MA, Roger S, Goette A, Rempp BA, Kuck KH, Najarn KB, Gutterman DD, Rousso B, Burkhoff D, Hasenfuss G. Cardc contracty modulatn proves long-term surval and hospalatns heart faure wh reduced ejectn fractn. Eur J Heart Fa. 2019 Sep;21(9):1103-1113. do 10.1002/ejhf.1374. Epub 2019 Jan 16.
Italian Registry on Cardiac Contractility Modulation Therapy

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT04327323Test

المؤلفون: University of California, Los Angeles, Columbia University, The Cleveland Clinic, Massachusetts General Hospital, Newark Beth Israel Medical Center, Cedars-Sinai Medical Center, Groupe Hospitalier Pitie-Salpetriere, Papworth Hospital NHS Foundation Trust, Azienda Ospedaliera S. Maria della Misericordia, Royal Brompton & Harefield NHS Foundation Trust, Indiana University

المصدر: Prospective, Multicenter, Randomized, Clinical Investigation of TransMedics Organ Care System (OCS) for Cardiac Use

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT00855712Test