دورية أكاديمية
Potential Role of In Vitro-In Vivo Correlations (IVIVC) for the Development of Plant-Derived Anticancer Drugs
| العنوان: | Potential Role of In Vitro-In Vivo Correlations (IVIVC) for the Development of Plant-Derived Anticancer Drugs |
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| المؤلفون: | Azeeze, Mohamed S.T.A., Santhosh, Shanthi B., Manjari, Murugesan S., Meyyanathan, Subramania N. |
| المساهمون: | Indian Council of Medical Research |
| المصدر: | Current Drug Targets ; volume 22, issue 12, page 1357-1375 ; ISSN 1389-4501 |
| بيانات النشر: | Bentham Science Publishers Ltd. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Clinical Biochemistry, Drug Discovery, Pharmacology, Molecular Medicine |
| الوصف: | Background: Conventional medicines, along with herbal formulations of Chinese, serve as the primary source and hub of active new drugs where the initial research concentrates on the extraction and isolation of bioactive lead compound(s) to treat several diseases largely for cancer. Plant-derived natural products and their analogs reveal a significant source of several clinically useful anticancer agents. Herbs and herbal derived active compounds play an unavoidable role in the treatment, drug discovery and delivery for decades, as evidenced by numerous existing marked drugs and various cancer-related molecular targets in clinical development. Objective: Solubility, resistance and metabolic limitations of the drug can be overcome by suitable molecular modifications. Due to enhancements in tumor targeting technology, some agents who failed in earlier clinical studies are also stimulating renewed interest. In this connection, In Vitro-In Vivo Correlation (IVIVC) plays an important role in the development of dosage forms in the field of pharmaceutical technology. Conclusion: IVIVC tool fastens and improves the drug development process and product quality, which is also utilized in internal control for scale-up to improve formulations and alternative production processes. Most importantly, this IVIVC tool lessens the number of human studies during new pharmaceuticals developments. In this review, we would like to grab the attention of readers to the importance and significance of IVIVC for natural products of anticancer drugs examples such as Docetaxel, Etoposide phosphate, 6-Gingerol, Capsaicin, etc. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.2174/1389450121999201113110433 |
| الإتاحة: | https://doi.org/10.2174/1389450121999201113110433Test https://eurekaselect.com/article/download/187969Test https://www.eurekaselect.com/187969/articleTest |
| رقم الانضمام: | edsbas.22EBA08E |
| قاعدة البيانات: | BASE |
| DOI: | 10.2174/1389450121999201113110433 |
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