المؤلفون: Ciria C. Hernandez, Luis E. Gimenez, Tim Strassmaier, Marc Rogers, Jean-Marc Taymans

المصدر: Frontiers in Molecular Neuroscience, Vol 17 (2024)

مصطلحات موضوعية: ion channel, high throughput screening (HTS), drug discovery and development, automated patch clamp (APC), channelopathy, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fnmol.2024.1414816/fullTest; https://doaj.org/toc/1662-5099Test

الوصول الحر: https://doaj.org/article/c2dab91b3959449c94cfaf652789a345Test

المؤلفون: Kate L. Thomson, Connie Jiang, Ebony Richardson, Dominik S. Westphal, Tobias Burkard, Cordula M. Wolf, Matteo Vatta, Steven M. Harrison, Jodie Ingles, Connie R. Bezzina, Brett M. Kroncke, Jamie I. Vandenberg, Chai-Ann Ng

المصدر: HGG Advances, Vol 5, Iss 2, Pp 100270- (2024)

مصطلحات موضوعية: Arrhythmia, Automated Patch Clamp, Variant classification, Variant of Uncertain Significance, long QT syndrome, Functional assay, Genetics, QH426-470

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2666247724000095Test; https://doaj.org/toc/2666-2477Test

الوصول الحر: https://doaj.org/article/45cd34fb97534a84883eace8c131e642Test

المؤلفون: Meye Bloothooft, Bente Verbruggen, Fitzwilliam Seibertz, Marcel A. G. van der Heyden, Niels Voigt, Teun P. de Boer

المصدر: Frontiers in Physiology, Vol 15 (2024)

مصطلحات موضوعية: automated patch clamp, cardiac electrophysiology, Cs+, drugs, hERG, conductance, Physiology, QP1-981

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fphys.2024.1298340/fullTest; https://doaj.org/toc/1664-042XTest

الوصول الحر: https://doaj.org/article/ae8be112595044e9923a346cd08dfa5fTest

المؤلفون: Bloothooft, Meye, Verbruggen, Bente, Seibertz, Fitzwilliam, van der Heyden, Marcel A G, Voigt, Niels, de Boer, Teun P

المساهمون: Medische Fysiologie, Circulatory Health

مصطلحات موضوعية: Cs, automated patch clamp, cardiac electrophysiology, conductance, drugs, hERG, hiPSC-CM, ion channel, Physiology (medical), Physiology

وصف الملف: application/pdf

العلاقة: https://dspace.library.uu.nl/handle/1874/451336Test

الإتاحة: https://dspace.library.uu.nl/handle/1874/451336Test

المؤلفون: Thomson, KL, Jiang, C, Richardson, E, Westphal, DS, Burkard, T, Wolf, CM, Vatta, M, Harrison, SM, Ingles, J, Bezzina, CR, Kroncke, BM, Vandenberg, JI, Ng, CA

المصدر: urn:ISSN:2666-2477 ; Human Genetics and Genomics Advances, 5, 2, 100270

مصطلحات موضوعية: Clinical Research, Cardiovascular, Pediatric, Genetics, Heart Disease, 2 Aetiology, 2.1 Biological and endogenous factors, Arrhythmia, Automated Patch Clamp, Electrophysiology, Functional assay, Variant classification, Variant of Uncertain Significance, long QT syndrome, Child, Humans, Death, Sudden, ERG1 Potassium Channel, Heart, Mutation, Missense

العلاقة: http://hdl.handle.net/1959.4/unsworks_85317Test; https://doi.org/10.1016/j.xhgg.2024.100270Test

الإتاحة: https://doi.org/10.1016/j.xhgg.2024.100270Test
http://hdl.handle.net/1959.4/unsworks_85317Test

المؤلفون: Joanne G. Ma, Jamie I. Vandenberg, Chai-Ann Ng

المصدر: Frontiers in Physiology, Vol 14 (2023)

مصطلحات موضوعية: cardiac electrophysiology, inheritable arrhythmia, automated patch clamp, SCN5A, KCNH2, KCNQ1, Physiology, QP1-981

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fphys.2023.1294741/fullTest; https://doaj.org/toc/1664-042XTest

الوصول الحر: https://doaj.org/article/a32dd2fd1ad84ff1a94824be606a5afbTest

المؤلفون: Mònica Campàs, Jaume Reverté, Àngels Tudó, Mounira Alkassar, Jorge Diogène, Francesc X. Sureda

المصدر: Marine Drugs, Vol 22, Iss 4, p 176 (2024)

مصطلحات موضوعية: tetrodotoxin, Neuro-2a cells, automated patch clamp, pufferfish, Biology (General), QH301-705.5

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/1660-3397/22/4/176Test; https://doaj.org/toc/1660-3397Test

الوصول الحر: https://doaj.org/article/fc9ae4f1623c4fcd8dec0206b0f24707Test

المؤلفون: Maksym Platonov, Oleksandr Maximyuk, Alexey Rayevsky, Vasyl Hurmach, Olena Iegorova, Vasyl Naumchyk, Elijah Bulgakov, Andrii Cherninskyi, Danil Ozheredov, Serhiy V. Ryabukhin, Oleg Krishtal, Dmytro M. Volochnyuk

المصدر: International Journal of Molecular Sciences, Vol 25, Iss 7, p 3584 (2024)

مصطلحات موضوعية: acid-sensitive ion channel, virtual screening, drug discovery, screening assay, automated patch clamp, Biology (General), QH301-705.5, Chemistry, QD1-999

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/1422-0067/25/7/3584Test; https://doaj.org/toc/1661-6596Test; https://doaj.org/toc/1422-0067Test

الوصول الحر: https://doaj.org/article/56c51cb163434511b1126364646b356fTest

المؤلفون: Tianbo Li, Martin Ginkel, Ada X. Yee, Leigh Foster, Jun Chen, Stephan Heyse, Stephan Steigele

المصدر: SLAS Discovery, Vol 27, Iss 4, Pp 278-285 (2022)

مصطلحات موضوعية: Automated patch clamp, Electrophysiology, High-throughput screening, Data analysis, Ion channel, Medicine (General), R5-920, Biotechnology, TP248.13-248.65

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2472555221000162Test; https://doaj.org/toc/2472-5552Test

الوصول الحر: https://doaj.org/article/0c6cb9340f7b43a0abde5b4e5da47769Test

المؤلفون: Lopez, Ludivine, de Waard, Stephan, Meudal, Hervé, Caumes, Cécile, Khakh, Kuldip, Peigneur, Steve, Oliveira-Mendes, Barbara, Lin, Sophia, de Waele, Jolien, Montnach, Jérôme, Cestèle, Sandrine, Tessier, Agnès, Johnson, J.P., Mantegazza, Massimo, Tytgat, Jan, Cohen, Charles, Béroud, Rémy, Bosmans, Frank, Landon, Céline, de Waard, Michel

المساهمون: ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX-lab), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Centre de biophysique moléculaire (CBM), Université d'Orléans (UO)-Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS), Universiteit Gent = Ghent University (UGENT), Institut de pharmacologie moléculaire et cellulaire (IPMC), Université Nice Sophia Antipolis (1965 - 2019) (UNS)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UniCA)

المصدر: ISSN: 0753-3322.

مصطلحات موضوعية: Drug discovery, JzTx-34, Pharmacology, hNa v 1.1 channel, Biophysics, High-throughput screening, Automated patch clamp, Cellular assay, Peptide synthesis, Lead optimization, Structural functional relationships, Dravet disease, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology

العلاقة: hal-04224866; https://hal.science/hal-04224866Test; https://hal.science/hal-04224866/documentTest; https://hal.science/hal-04224866/file/Lopez2023.pdfTest

الإتاحة: https://doi.org/10.1016/j.biopha.2023.115173Test
https://hal.science/hal-04224866Test
https://hal.science/hal-04224866/documentTest
https://hal.science/hal-04224866/file/Lopez2023.pdfTest