المؤلفون: Lan Zhang, Y. Wang, Jessica M. Salmon, Corina Ghiurau, Andrew H. Wei, David C.S. Huang, Donia M Moujalled, Audrey Claperon, Olivier Geneste, Sarah MacRaild, Ping Lan, Guillaume Lessene, David J. Segal, Ana Leticia Maragno, Frédéric Colland, Tse-Chieh Teh, Laurence Kraus-Berthier, Adrien Zichi, Francesca Rocchetti, Giovanna Pomilio, Andrew W. Roberts, Adam Ivey, Ing Soo Tiong, Erick Morris, Maïa Chanrion, Ensar Halilovic, Sewa Rijal

المصدر: Leukemia

مصطلحات موضوعية: Male, 0301 basic medicine, Cancer Research, Myeloid, Mice, SCID, Mice, chemistry.chemical_compound, 0302 clinical medicine, Biomimetics, Mice, Inbred NOD, hemic and lymphatic diseases, Tumor Cells, Cultured, MCL1, Sulfonamides, Hematology, Myeloid leukemia, Leukemia, Myeloid, Acute, Leukemia, medicine.anatomical_structure, Proto-Oncogene Proteins c-bcl-2, Oncology, 030220 oncology & carcinogenesis, Drug Therapy, Combination, Female, medicine.medical_specialty, Antineoplastic Agents, Thiophenes, Article, Acute myeloid leukaemia, 03 medical and health sciences, Proto-Oncogene Proteins, Internal medicine, medicine, Animals, Humans, Venetoclax, business.industry, Translational research, Bridged Bicyclo Compounds, Heterocyclic, medicine.disease, Xenograft Model Antitumor Assays, Peptide Fragments, Myeloid Cell Leukemia Sequence 1 Protein, Pyrimidines, 030104 developmental biology, chemistry, Cancer research, Bone marrow, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62d5dc6690c6daf00a067441f8d8707eTest
https://doi.org/10.1038/s41375-018-0261-3Test

المؤلفون: Ana-Leticia Maragno, Attila Paczal, András Kotschy, Didier Demarles, James Edward Paul Davidson, Szlávik Zoltán, Allan E. Surgenor, Gaëtane Le Toumelin-Braizat, James Murray, Proszenyák Ágnes, Frédéric Colland, Gabor Radics, Szabolcs Sipos, Olivier Geneste, Balázs Bálint, Csékei Márton, Zoltán B. Szabó, Pawel Dokurno, Audrey Claperon, Anne-Marie Girard, Chen I-Jen, Alain Bruno, Gaëlle Lysiak-Auvity, Roderick E. Hubbard, Maïa Chanrion, Zoe Daniels

المصدر: Journal of medicinal chemistry. 63(22)

مصطلحات موضوعية: Myeloid, Cell, Antineoplastic Agents, Mice, SCID, 01 natural sciences, Protein Structure, Secondary, 03 medical and health sciences, chemistry.chemical_compound, Mice, Downregulation and upregulation, Drug Discovery, medicine, Animals, Humans, 030304 developmental biology, 0303 health sciences, Dose-Response Relationship, Drug, Cancer, medicine.disease, HCT116 Cells, Small molecule, 0104 chemical sciences, Protein Structure, Tertiary, 010404 medicinal & biomolecular chemistry, Leukemia, medicine.anatomical_structure, Cell killing, chemistry, Cancer research, Molecular Medicine, Myeloid Cell Leukemia Sequence 1 Protein, Female, Lead compound, HeLa Cells

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4627a227ab78ca732e02dade24b1f98Test
https://pubmed.ncbi.nlm.nih.gov/33146521Test

المؤلفون: Didier Demarles, James Edward Paul Davidson, Levente Ondi, Allan E. Surgenor, Frédéric Colland, Attila Paczal, Marion Zarka, Alan P. Robertson, Zoltán B. Szabó, András Kotschy, Julia Smith, Perron-Sierra Françoise, Gabor Radics, Audrey Claperon, Ben Davis, Pawel Dokurno, Szlávik Zoltán, Csékei Márton, Gaetane LeToumelin-Braizat, Roderick E. Hubbard, Chen I-Jen, C. Pedder, Olivier Geneste, James Murray, Nicolas Cauquil

المصدر: Journal of medicinal chemistry. 62(15)

مصطلحات موضوعية: Cell Survival, Cell, Thiophenes, 01 natural sciences, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Downregulation and upregulation, Drug Discovery, medicine, Humans, Caspase, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, biology, Drug discovery, HCT116 Cells, Small molecule, 0104 chemical sciences, Amino acid, Protein Structure, Tertiary, 010404 medicinal & biomolecular chemistry, medicine.anatomical_structure, Pyrimidines, chemistry, biology.protein, Cancer research, Molecular Medicine, Myeloid Cell Leukemia Sequence 1 Protein, Growth inhibition, Lead compound, HeLa Cells

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a41342aba1a0624428d0d485578fc3d6Test
https://pubmed.ncbi.nlm.nih.gov/31339316Test

المؤلفون: Patrick Casara, James Davidson, Audrey Claperon, Gaëtane Le Toumelin-Braizat, Meike Vogler, Alain Bruno, Maïa Chanrion, Gaëlle Lysiak-Auvity, Thierry Le Diguarher, Jérôme-Benoît Starck, Ijen Chen, Neil Whitehead, Christopher Graham, Natalia Matassova, Pawel Dokurno, Christopher Pedder, Youzhen Wang, Shumei Qiu, Anne-Marie Girard, Emilie Schneider, Fabienne Gravé, Aurélie Studeny, Ghislaine Guasconi, Francesca Rocchetti, Sophie Maïga, Jean-Michel Henlin, Frédéric Colland, Laurence Kraus-Berthier, Steven Le Gouill, Martin J.S. Dyer, Roderick Hubbard, Mike Wood, Martine Amiot, Gerald M Cohen, John A. Hickman, Erick Morris, James Murray, Olivier Geneste

المساهمون: Institut de Recherches Servier, Vernalis (R&D) Ltd, Institute for Experimental Cancer Research in Pediatrics, Goethe-Universität Frankfurt am Main, Institut de Recherches Internationales Servier [Suresnes] (IRIS), Novartis Institute of Biomedical Research, Oncology Drug Discovery, Regulation of Bcl2 and p53 Networks in Multiple Myeloma and Mantle Cell Lymphoma (CRCINA-ÉQUIPE 10), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA), Ernest and Helen Scott Haematological Research Institute, University of Leicester, Institute of Translational Medicine, University of Liverpool, Goethe-University Frankfurt, Institut de Recherches Internationales Servier [Suresnes] ( IRIS ), Regulation of Bcl2 and p53 networks in Multiple Myeloma and Mantle Cell Lymphoma ( CRCINA - Département NOHMAD - Equipe 10 ), Centre de recherche de Cancérologie et d'Immunologie / Nantes - Angers ( CRCINA ), Université d'Angers ( UA ) -Université de Nantes ( UN ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ) -Institut de Recherche en Santé de l'Université de Nantes ( IRS-UN ) -Centre hospitalier universitaire de Nantes ( CHU Nantes ) -Université d'Angers ( UA ) -Université de Nantes ( UN ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ) -Institut de Recherche en Santé de l'Université de Nantes ( IRS-UN ) -Centre hospitalier universitaire de Nantes ( CHU Nantes ), Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes), Bernardo, Elizabeth

المصدر: Oncotarget
Oncotarget, Impact journals, 2018, 9 (28), pp.20075-20088. ⟨10.18632/oncotarget.24744⟩
Oncotarget, Impact journals, 2018, 9 (28), pp.20075-20088. 〈10.18632/oncotarget.24744〉
Oncotarget, 2018, 9 (28), pp.20075-20088. ⟨10.18632/oncotarget.24744⟩

مصطلحات موضوعية: 0301 basic medicine, apoptosis, BCL-2, [SDV.CAN]Life Sciences [q-bio]/Cancer, BH3-mimetics, [ SDV.CAN ] Life Sciences [q-bio]/Cancer, 3. Good health, inhibitor, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, [SDV.CAN] Life Sciences [q-bio]/Cancer, Oncology, 030220 oncology & carcinogenesis, hematological malignancies, Research Paper

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a85daeabf79a548e35d6497ffd721f08Test
https://www.hal.inserm.fr/inserm-01807731Test

المؤلفون: Fernandez Sanchez Maria Elena, Maria Elena Fernandez-Sanchez, Sandrine Barbier, Heldmuth Latorre-Ossa, Hélène Marie, Colette Rey, Laura Fouassier, Audrey Claperon, Chantal Housset, Sylviane Lesieur, Jean-Luc Gennisson, Mickaël Tanter, Emmanuel Farge

المصدر: Protocol Exchange.

مصطلحات موضوعية: Growth pressure, In vivo, Chemistry, General Earth and Planetary Sciences, Anatomy, Mechanotransduction, General Environmental Science, Biomedical engineering

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::1e520f72c843b0c2de11b7f1db591a54Test
https://doi.org/10.1038/protex.2014.052Test