دورية أكاديمية
Repeated lipoprotein apheresis and immune response: Effects on different immune cell populations
| العنوان: | Repeated lipoprotein apheresis and immune response: Effects on different immune cell populations |
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| المؤلفون: | Walther, Romy, Wehner, Rebekka, Tunger, Antje, Julius, Ulrich, Schatz, Ulrike, Tselmin, Sergey, Bornstein, Stefan R., Schmitz, Marc, Graessler, Juergen |
| حالة النشر: | publishedVersion |
| بيانات النشر: | Wiley-Blackwell, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Original Material: | urn:nbn:de:bsz:14-qucosa2-919774 |
| مصطلحات موضوعية: | atherosclerosis, lipoprotein apheresis, monocytes, NK cells, T cells, Atherosklerose, Lipoprotein-Apherese, Monozyten, NK-Zellen, T-Zellen, info:eu-repo/classification/ddc/610, ddc:610 |
| الوصف: | Background: Atherosclerosis is considered a chronic inflammation of arterial vessels with the involvement of several immune cells causing severe cardiovascular diseases. Lipoprotein apheresis (LA) improves cardiovascular conditions of patients with severely disturbed lipid metabolism. In this context, little is known about the impact of LA on various immune cell populations, especially over time. Methods: Immune cells of 18 LA-naïve patients starting weekly LA treatment were analyzed before and after four apheresis cycles over the course of 24 weeks by flow cytometry. Results and Conclusions: An acute lowering effect of LA on T cell and natural killer (NK) cell subpopulations expressing CD69 was observed. The nonclassical and intermediate monocyte subsets as well as HLA-DR+ 6-sulfo LacNAc+ monocytes were significantly reduced during the apheresis procedure. We conclude that LA has the capacity to alter various immune cell subsets. However, LA has mainly short-term effects than long-term consequences on proportions of immune cells. |
| Original Identifier: | oai:qucosa:de:qucosa:91977 |
| نوع الوثيقة: | Article |
| اللغة: | English |
| تدمد: | 1744-9987 |
| DOI: | 10.1111/1744-9987.13886 |
| الإتاحة: | https://tud.qucosa.de/id/qucosa%3A91977Test https://tud.qucosa.de/api/qucosa%3A91977/attachment/ATT-0Test/ |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsndl.DRESDEN.oai.qucosa.de.qucosa.91977 |
| قاعدة البيانات: | Networked Digital Library of Theses & Dissertations |
| تدمد: | 17449987 |
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| DOI: | 10.1111/1744-9987.13886 |