Insulin Glargine versus Neutral Protamine Hagedorn Insulin in Young and Preschool Children with Type 1 Diabetes Mellitus
| العنوان: | Insulin Glargine versus Neutral Protamine Hagedorn Insulin in Young and Preschool Children with Type 1 Diabetes Mellitus |
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| المؤلفون: | Khadiga Yehia Eltonbary, Assad Abolela, Eman M Sherif, Manal Abd Alaziz |
| المصدر: | Egyptian Journal of Hospital Medicine; Vol. 85 No. 1 (2021); 2730-2733 |
| بيانات النشر: | Egypts Presidential Specialized Council for Education and Scientific Research, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Insulin Glargine, Neutral Protamine Hagedorn insulin, Type 1 diabetes mellitus, medicine.medical_specialty, Type 1 diabetes, business.industry, Insulin glargine, Insulin, medicine.medical_treatment, NPH insulin, medicine.disease, Gastroenterology, Diabetes management, Internal medicine, medicine, Regular insulin, medicine.symptom, business, Weight gain, Glycemic, medicine.drug |
| الوصف: | Background: Diabetic patients need to maintain tight glycemic control to avoid long term complications. Children need to achieve tight control without the risk of hypoglycemic excursions. Objective: To assess the safety and efficacy of insulin glargine as a basal insulin in type 1 diabetic children aged 3 to 8 years old in comparison to neutral protamine Hagedorn (NPH) insulin as regards the key parameters of diabetes management and low-grade inflammation. Patients and Methods: Fifty children aged 3-8 years old with type 1 diabetes mellitus following in pediatric diabetes clinic, Ain Shams University Hospital were enrolled in this study. They were randomized into two groups, group A: shifted from NPH insulin to basal-bolus regimen using insulin glargine once a day and group B: kept on using NPH insulin two to three times a day. Both used regular insulin or rapid acting analogues at mealtime. Results: At six months, weight gain was significantly higher among group B patients 0.6 kg (±0.14 SD) vs 0.38 kg, mean fasting blood sugar was lower in group A, 109.1(+17) mg/dl versus 125.3(+20) mg/dl in group B. HbA1C showed significant improvement in both groups with tight control, however group A was better with a mean of 6.7(+0.5)% versus 7.4(+0.7) and still with significantly less hypoglycemic excursions. Hs-CRP as a marker of inflammation showed significant drop with better overall control independent of the basal insulin used. Conclusion: Insulin glargine as once daily basal insulin is safe in achieving good glycemic control in young and preschool children with less hypoglycemic excursions. |
| وصف الملف: | application/pdf |
| تدمد: | 2090-7125 2730-2733 1687-2002 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6663416fb18afddc274dac8e9fb1d0dTest https://doi.org/10.21608/ejhm.2021.189839Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f6663416fb18afddc274dac8e9fb1d0d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20907125 27302733 16872002 |
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