Genetic Polymorphisms of X-ray Repair Cross-Complementing Group 1 and Apurinic/Apyrimidinic Endonuclease-1 in Chronic Obstructive Pulmonary Disease
| العنوان: | Genetic Polymorphisms of X-ray Repair Cross-Complementing Group 1 and Apurinic/Apyrimidinic Endonuclease-1 in Chronic Obstructive Pulmonary Disease |
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| المؤلفون: | Pratibha Nallari, Aleem Ahmed Khan, Asfaq Hasan, Gallapalli Sravani, Baderuzzaman, Syed Mehmood Ahmed, Nagarapu Raju, Nazima Begum, Avinash Bardia, Shaik Iqbal, Narneni Lavanya, Chandrakala Lakki Reddy, Sandeep Kumar Vishwakarma, Naziya Usma |
| المصدر: | Inflammation. |
| بيانات النشر: | Springer Science and Business Media LLC, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Adult, 0301 basic medicine, medicine.medical_specialty, Pathology, Adolescent, Genotype, Immunology, Biology, Gastroenterology, law.invention, Pulmonary Disease, Chronic Obstructive, 03 medical and health sciences, XRCC1, 0302 clinical medicine, law, Internal medicine, DNA-(Apurinic or Apyrimidinic Site) Lyase, medicine, Humans, Immunology and Allergy, Genetic Predisposition to Disease, Polymerase chain reaction, COPD, Polymorphism, Genetic, Genome, Human, Haplotype, Case-control study, Middle Aged, medicine.disease, DNA-(apurinic or apyrimidinic site) lyase, Rheumatology, DNA-Binding Proteins, X-ray Repair Cross Complementing Protein 1, 030104 developmental biology, Case-Control Studies, 030220 oncology & carcinogenesis |
| الوصف: | Chronic obstructive pulmonary disease (COPD) is a heterogeneous collection of conditions characterized by irreversible expiratory airflow limitation. The disease is interspersed with exacerbations; periods of acute symptomatic, physiological, and functional deterioration. The present study was designed to investigate the role of X-ray cross-complementing group 1 (XRCC1) and apurinic/apyrimidinic endonuclease 1 (APE1) polymorphisms and the risk of COPD. Blood samples from 354 unrelated subject (age range 18-60 years; 156 with COPD, 198 healthy controls) were collected. Genomic DNA was isolated and genotyped for XRCC1 Arg399Gln and APE1 Asp148Glu using a confronting two pair primers polymerase chain reaction. GA genotype of XRCC1 gene was found to be predominant in the COPD group compared to controls with 1.86-fold increased risk for COPD (OR 1.86, 95 % CI 1.20-2.88, p = 0.0013). TG genotype of APE1 was found to be predominant in COPD group compared to controls with the difference being statistically significant (OR 1.68, 95 % CI 1.08-2.61, p = 0.0043). The GA haplotype was found to be predominant in COPD than controls with a 2.19-fold significant increase (OR 2.19, 95 % CI 1.46-3.28, p = 0.003). Polymorphism in XRCC1 and APE1 gene is associated with an increased risk of COPD. |
| تدمد: | 1573-2576 0360-3997 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94f4822d9d4cba40f734ae69cf88557aTest https://doi.org/10.1007/s10753-016-0355-xTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....94f4822d9d4cba40f734ae69cf88557a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15732576 03603997 |
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