المؤلفون: Wessel A. C. Burger (11236813), Patrick R. Gentry (2317555), Alice E. Berizzi (5145614), Ziva Vuckovic (11236816), Emma T. van der Westhuizen (5003858), Geoff Thompson (11236819), Mahmuda Yeasmin (7828862), Craig W. Lindsley (203380), Patrick M. Sexton (538750), Christopher J. Langmead (232083), Andrew B. Tobin (7589429), Arthur Christopoulos (538751), Celine Valant (1583104), David M. Thal (10925177)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Pharmacology, Evolutionary Biology, Cancer, Infectious Diseases, Chemical Sciences not elsewhere classified, ML 375, NAM, TM, Novel Allosteric Site, M 5 muscarinic acetylcholine receptor, M 5 mAChR, binding site, modulator, ML 375 binding site, allosteric site

العلاقة: https://figshare.com/articles/journal_contribution/Identification_of_a_Novel_Allosteric_Site_at_the_M_sub_5_sub_Muscarinic_Acetylcholine_Receptor/15113365Test

الإتاحة: https://doi.org/10.1021/acschemneuro.1c00383.s001Test

المؤلفون: Stephen Ph Alexander (11487694), Eamonn Kelly (11487697), Alistair Mathie (5435468), John A Peters (11487700), Emma L Veale (11487703), Jane F Armstrong (11487706), Elena Faccenda (5169479), Simon D Harding (5169467), Adam J Pawson (5169476), Christopher Southan (2285677), O Peter Buneman (11487709), John A Cidlowski (7953521), Arthur Christopoulos (538751), Anthony P Davenport (11487712), Doriano Fabbro (156139), Michael Spedding (2160046), Jörg Striessnig (8272236), Jamie A Davies (5169470), Katelin E Ahlers-Dannen (11487715), Mohammed Alqinyah (11487718), Thiruma Arumugam (9481307), Christopher Bodle (11487721), Josephine Buo Dagner (11487724), Bandana Chakravarti (1738120), Shreoshi P Choudhuri (11487727), Kirk M Druey (11487730), Rory A Fisher (11487733), Kyle J Gerber (11487736), John R Hepler (11487739), Shelley B Hooks (11487742), Havish S Kantheti (11487745), Behirda Karaj (11487748), Somayeh Layeghi-Ghalehsoukhteh (11487751), Jae-Kyung Lee (346085), Zili Luo (11487754), Kirill Martemyanov (3583610), Luke D Mascarenhas (11487757), Harrison McNabb (11487760), Carolina Montañez-Miranda (11487763), Osita Ogujiofor (11487766), Hoa Phan (1301841), David L Roman (11487769), Vincent Shaw (11487772), Benita Sjogren (11487775), Christopher Sobey (7138634), Mackenzie M Spicer (11487778), Katherine E Squires (11487781), Laurie Sutton (11487784), Menbere Wendimu (11487787), Thomas Wilkie (11487790), Keqiang Xie (7486154), Qian Zhang (49333), Yalda Zolghadri (11487793)

مصطلحات موضوعية: Uncategorized, Pharmacology & Pharmacy

العلاقة: https://figshare.com/articles/journal_contribution/The_Concise_Guide_to_Pharmacology_2021_22_Introduction_and_Other_Protein_Targets/16689469Test

الإتاحة: https://doi.org/10.26181/615271da28e1cTest

المؤلفون: Matthew C. L. Wakeham (11836887), Briana J. Davie (11836890), David K. Chalmers (1455451), Arthur Christopoulos (538751), Ben Capuano (1435147), Celine Valant (1583104), Peter J. Scammells (694050)

مصطلحات موضوعية: Biophysics, Biochemistry, Molecular Biology, Pharmacology, Biotechnology, Evolutionary Biology, Cancer, Infectious Diseases, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, muscarinic acetylcholine receptors, machr responses compared, restoring nonselective agonism, methoxybenzyl )- 4, ligands possessed noticeable, possible allosteric interaction, machr selective agonists, machr subtypes suggests, 1 -( 4, 4 , efficacy selective agonists, 1 , 5 , selective agonism, machr subtypes, n <, hybrid ligands, allosteric site, allosteric pharmacophore, machr selectivity

العلاقة: https://figshare.com/articles/journal_contribution/Structural_Features_of_Iperoxo_BQCA_Muscarinic_Acetylcholine_Receptor_Hybrid_Ligands_Determining_Subtype_Selectivity_and_Efficacy/17203743Test

الإتاحة: https://doi.org/10.1021/acschemneuro.1c00572.s001Test

المؤلفون: Jesse I. Mobbs (10925173), Matthew J. Belousoff (2395753), Kaleeckal G. Harikumar (177023), Sarah J. Piper (10925175), Xiaomeng Xu (313387), Sebastian G. B. Furness (6236942), Hari Venugopal (5573870), Arthur Christopoulos (538751), Radostin Danev (8604666), Denise Wootten (2585149), David M. Thal (10925177), Laurence J. Miller (177040), Patrick M. Sexton (538750)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Molecular Biology, Evolutionary Biology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, CCK 1R core, CCK peptide agonist, G protein binding pocket, GPCR, type 1 receptor, G protein selectivity, heterotrimeric G proteins, CCK 1R, Gq

العلاقة: https://figshare.com/articles/journal_contribution/Data_collection_and_refinement_statistics_/14735899Test

الإتاحة: https://doi.org/10.1371/journal.pbio.3001295.s008Test

المؤلفون: Jesse I. Mobbs (10925173), Matthew J. Belousoff (2395753), Kaleeckal G. Harikumar (177023), Sarah J. Piper (10925175), Xiaomeng Xu (313387), Sebastian G. B. Furness (6236942), Hari Venugopal (5573870), Arthur Christopoulos (538751), Radostin Danev (8604666), Denise Wootten (2585149), David M. Thal (10925177), Laurence J. Miller (177040), Patrick M. Sexton (538750)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Molecular Biology, Evolutionary Biology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, CCK 1R core, CCK peptide agonist, G protein binding pocket, GPCR, type 1 receptor, G protein selectivity, heterotrimeric G proteins, CCK 1R, Gq

العلاقة: https://figshare.com/articles/journal_contribution/Uncropped_Coomassie-stained_SDS-PAGE_gels_used_for_S1F_and_S1H_Fig_/14735931Test

الإتاحة: https://doi.org/10.1371/journal.pbio.3001295.s018Test

المؤلفون: Kaleeckal G. Harikumar (177023), Thomas Coudrat (2585143), Aditya J. Desai (11801642), Maoqing Dong (2166379), Daniela G. Dengler (9214461), Sebastian G. B. Furness (6236942), Arthur Christopoulos (538751), Denise Wootten (2585149), Eduard A. Sergienko (9214467), Patrick M. Sexton (538750), Laurence J. Miller (177040)

مصطلحات موضوعية: Endocrinology, Reproduction, Cell Metabolism, cholecystokinin, cholecystokinin receptor, allosteric modulation, cholesterol, obesity

العلاقة: https://figshare.com/articles/dataset/Table_1_Discovery_of_a_Positive_Allosteric_Modulator_of_Cholecystokinin_Action_at_CCK1R_in_Normal_and_Elevated_Cholesterol_xlsx/17133938Test

الإتاحة: https://doi.org/10.3389/fendo.2021.789957.s001Test

المؤلفون: Jesse I. Mobbs (10925173), Matthew J. Belousoff (2395753), Kaleeckal G. Harikumar (177023), Sarah J. Piper (10925175), Xiaomeng Xu (313387), Sebastian G. B. Furness (6236942), Hari Venugopal (5573870), Arthur Christopoulos (538751), Radostin Danev (8604666), Denise Wootten (2585149), David M. Thal (10925177), Laurence J. Miller (177040), Patrick M. Sexton (538750)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Molecular Biology, Evolutionary Biology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, CCK 1R core, CCK peptide agonist, G protein binding pocket, GPCR, type 1 receptor, G protein selectivity, heterotrimeric G proteins, CCK 1R, Gq

العلاقة: https://figshare.com/articles/figure/Expression_and_purification_of_CCK-8_CCK1R_G_protein_complexes_/14735877Test

الإتاحة: https://doi.org/10.1371/journal.pbio.3001295.s001Test

المؤلفون: Jesse I. Mobbs (10925173), Matthew J. Belousoff (2395753), Kaleeckal G. Harikumar (177023), Sarah J. Piper (10925175), Xiaomeng Xu (313387), Sebastian G. B. Furness (6236942), Hari Venugopal (5573870), Arthur Christopoulos (538751), Radostin Danev (8604666), Denise Wootten (2585149), David M. Thal (10925177), Laurence J. Miller (177040), Patrick M. Sexton (538750)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Molecular Biology, Evolutionary Biology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, CCK 1R core, CCK peptide agonist, G protein binding pocket, GPCR, type 1 receptor, G protein selectivity, heterotrimeric G proteins, CCK 1R, Gq

العلاقة: https://figshare.com/articles/figure/Comparison_of_CCK-8_binding_interactions_with_CCK1R_in_Gs_and_Gq_mimetic_protein_complexes_/14735883Test

الإتاحة: https://doi.org/10.1371/journal.pbio.3001295.s003Test

المؤلفون: Jesse I. Mobbs (10925173), Matthew J. Belousoff (2395753), Kaleeckal G. Harikumar (177023), Sarah J. Piper (10925175), Xiaomeng Xu (313387), Sebastian G. B. Furness (6236942), Hari Venugopal (5573870), Arthur Christopoulos (538751), Radostin Danev (8604666), Denise Wootten (2585149), David M. Thal (10925177), Laurence J. Miller (177040), Patrick M. Sexton (538750)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Molecular Biology, Evolutionary Biology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, CCK 1R core, CCK peptide agonist, G protein binding pocket, GPCR, type 1 receptor, G protein selectivity, heterotrimeric G proteins, CCK 1R, Gq

العلاقة: https://figshare.com/articles/figure/Local_resolution_and_atomic_modelling_into_the_cryo-EM_density_maps_/14735879Test

الإتاحة: https://doi.org/10.1371/journal.pbio.3001295.s002Test

المؤلفون: Jesse I. Mobbs (10925173), Matthew J. Belousoff (2395753), Kaleeckal G. Harikumar (177023), Sarah J. Piper (10925175), Xiaomeng Xu (313387), Sebastian G. B. Furness (6236942), Hari Venugopal (5573870), Arthur Christopoulos (538751), Radostin Danev (8604666), Denise Wootten (2585149), David M. Thal (10925177), Laurence J. Miller (177040), Patrick M. Sexton (538750)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Molecular Biology, Evolutionary Biology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, CCK 1R core, CCK peptide agonist, G protein binding pocket, GPCR, type 1 receptor, G protein selectivity, heterotrimeric G proteins, CCK 1R, Gq

العلاقة: https://figshare.com/articles/figure/Comparison_of_activation_motifs_between_CCK1-active_green_and_OX_sub_2_sub_R-active_pink_and_inactive_grey_/14735889Test

الإتاحة: https://doi.org/10.1371/journal.pbio.3001295.s005Test