التفاصيل البيبلوغرافية
| العنوان: |
A Wire-Based Continuous Glucose Sensor: Accurate Tracking of Blood Glucose During Multi-level Clamps in Dogs. |
| المؤلفون: |
Ward, W. Kenneth, Armer, Ben, Scott, Melanie, Bruce, Robert, Duman, Heather M., Cherrington, Alan D. |
| المصدر: |
Diabetes. Jun2007 Supplement 1, Vol. 56, pA114-A114. 1/4p. |
| مصطلحات موضوعية: |
*BLOOD sugar monitoring, *BIOSENSORS, *INSULIN, *BLOOD sugar, *HYPOGLYCEMIA, *DIABETES, *LABORATORY dogs |
| مستخلص: |
The value of a continuous glucose sensor depends on its ability to accurately measure glucose over a wide range of glucose in a stable fashion. We studied a subcutaneous (SC) interstitial amperometric glucose sensor in anesthetized dogs (n=10) in which glycemia was clamped for 12 hours. Multiple steady state levels ranging from 40 to 350 mg/dl were established for 30-40 minutes. Insulin was delivered through a peripheral vein at a rate of 2 mU/Kg/min throughout the study to clamp the arterial plasma insulin at 172 ± 6 µU/ml. In each animal, 3-4 wire sensors (diameter 330 µm, iSense Corp.), were placed SC in the dorsal region. The sensors were implanted 18 hours or immediately prior to start of the experiment. The former underwent 1-point calibrations immediately prior to the clamps while the others were calibrated using exponential decay equations to fit the time-related decline in sensor sensitivity. The sensors provided a reading every minute and arterial plasma glucose levels served as the reference values. The primary measures of accuracy for glucose values > 80 mg/dl were the median absolute relative difference (ARD) and mean ARD. The measures of accuracy for ≤ 80 were the median absolute difference (AD) or mean AD. Comparison of accuracy metrics at different glucose levels provided a measure of in vivo linearity. For BG 40-80, median AD was 14.5 mg/dl and mean AD was 20.3 mg/dl. For BG 81-120, median ARD was 8.5% and mean ARD was 11.1%. For BG 121-240, median ARD was 13.7% and mean ARD was 18.0%. For BG 241-350, median ARD was 8.4% and mean ARD was 12.9%. The sensors (n=31 total) tracked arterial glucose well over the entire range of glucose values. There was a slight decline of accuracy over the duration of the 10 hour study. We conclude that a wire-based microsensor tracks arterial glucose closely during prolonged glucose clamp studies. The sensor accurately measures glucose over a wide range of glucose levels, including the hypoglycemic range, which heretofore has been difficult to measure accurately. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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