المؤلفون: Tucker, Julie Ann, Myers, Stephanie M., Miller, Duncan C., Molyneux, Lauren, Arasta, Mercedes, Bawn, Ruth H., Blackburn, Timothy J., Cook, Simon J., Edwards, Noel, Endicott, Jane A., Golding, Bernard T., Griffin, Roger J., Hammonds, Tim, Hardcastle, Ian R., Harnor, Suzannah J., Heptinstall, Amy B., Lochhead, Pamela A., Martin, Mathew P., Martin, Nick C., Newell, David R., Owen, Paul J., Pang, Leon C., Reuillon, Tristan, Rigoreau, Laurent J.M., Thomas, Huw D., Wang, Lan-Zhen, Wong, Ai-Ching, Noble, Martin E.M., Wedge, Stephen R., Cano, Celine

وصف الملف: text

العلاقة: https://eprints.whiterose.ac.uk/148098/1/ERK5LeadIDPaper_EurJMedChem_2019_04_29.docxTest; Tucker, Julie Ann orcid.org/0000-0002-6119-676X , Myers, Stephanie M., Miller, Duncan C. et al. (27 more authors) (2019) Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38α and BRD4. European Journal of Medicinal Chemistry. pp. 530-543. ISSN 0223-5234

الإتاحة: https://doi.org/10.1016/j.ejmech.2019.05.057Test
https://eprints.whiterose.ac.uk/148098Test/
https://eprints.whiterose.ac.uk/148098/1/ERK5LeadIDPaper_EurJMedChem_2019_04_29.docxTest

المؤلفون: Myers, Stephanie M., Miller, Duncan C., Molyneux, Lauren, Arasta, Mercedes, Bawn, Ruth H., Blackburn, Timothy J., Cook, Simon J., Edwards, Noel, Endicott, Jane A., Golding, Bernard T., Griffin, Roger J., Hammonds, Tim, Hardcastle, Ian R., Harnor, Suzannah J., Heptinstall, Amy B., Lochhead, Pamela A., Martin, Mathew P., Martin, Nick C., Newell, David R., Owen, Paul J., Pang, Leon C., Reuillon, Tristan, Rigoreau, Laurent J.M., Thomas, Huw D., Tucker, Julie A., Wang, Lan-Zhen, Wong, Ai-Ching, Noble, Martin E.M., Wedge, Stephen R., Cano, Celine

المساهمون: Cancer Research UK, Medical Research Council

المصدر: European Journal of Medicinal Chemistry ; volume 178, page 530-543 ; ISSN 0223-5234

مصطلحات موضوعية: Organic Chemistry, Drug Discovery, Pharmacology, General Medicine

الإتاحة: https://doi.org/10.1016/j.ejmech.2019.05.057Test
https://api.elsevier.com/content/article/PII:S0223523419304672?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0223523419304672?httpAccept=text/plainTest

المؤلفون: Simon J. Cook, Mathew P. Martin, Julie A. Tucker, Miller Duncan Charles, Timothy J. Blackburn, Stephanie M. Myers, Ai-Ching Wong, Nick C. Martin, Mercedes Arasta, Martin E.M. Noble, Huw D. Thomas, Ruth H. Bawn, Lan-Zhen Wang, Noel Edwards, Pamela A. Lochhead, Celine Cano, Suzannah J. Harnor, Tristan Reuillon, Laurent Rigoreau, Lauren Molyneux, Roger J. Griffin, David R. Newell, Bernard T. Golding, Tim Hammonds, Amy B. Heptinstall, P.J. Owen, Stephen R. Wedge, Ian R. Hardcastle, Leon Pang, Jane A. Endicott

المساهمون: Myers, Stephanie, Miller, Duncan, Molyneux, Lauren, Arasta, Mercedes, Bawn, Ruth, Blackburn, Timothy, Cook, Simon, Edwards, Noel, Endicott, Jane, Golding, Bernard, Griffin, Roger, Hammonds, Tim, Hardcastle, Ian, Harnor, Suzannah, Heptinstall, Amy, Lochhead, Pamela, Martin, Mathew, Martin, Nick, Newell, Herbie, Owen, Paul, Pang, Leon, Reuillon, Tristan, Rigoreau, Laurent, Thomas, Huw, Tucker, Julie, Wang, Lan-Zhen, Wong, Ai-Ching, Noble, Martin, Wedge, Stephen, Cano, Celine

مصطلحات موضوعية: Angiogenesis, High-throughput screening, Motility, Administration, Oral, Biological Availability, Mice, Nude, Antineoplastic Agents, Cell Cycle Proteins, 01 natural sciences, Mitogen-Activated Protein Kinase 14, 03 medical and health sciences, Mice, Structure-Activity Relationship, Cell Line, Tumor, Drug Discovery, Extracellular, Animals, Humans, IC50, Protein Kinase Inhibitors, Mitogen-Activated Protein Kinase 7, 030304 developmental biology, Cell Proliferation, Pharmacology, sub_chemistry, 0303 health sciences, biology, sub_pharmacyandpharmacology, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Kinase, Organic Chemistry, Nuclear Proteins, General Medicine, Neoplasms, Experimental, 0104 chemical sciences, Endothelial stem cell, Biochemistry, Mitogen-activated protein kinase, biology.protein, Female, Drug Screening Assays, Antitumor, Transcription Factors

وصف الملف: application/vnd.openxmlformats-officedocument.wordprocessingml.document; application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b20469b74ddfa9b4388aacc50467a77Test
https://eprints.whiterose.ac.uk/148098/1/ERK5LeadIDPaper_EurJMedChem_2019_04_29.docxTest