The Impact of Serum Lipid Levels on Circulating Soluble Adhesion Molecules in Childhood
| العنوان: | The Impact of Serum Lipid Levels on Circulating Soluble Adhesion Molecules in Childhood |
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| المؤلفون: | Agelliki Chronopoulou, Dimitrios Gourgiotis, Maria Moustaki, Emmanuel Kavazarakis, Antonia Mavri, Apostolos Bossios, Petros M. Zeis, Themistocles Karpathios |
| المصدر: | Pediatric Research. 52:454-458 |
| بيانات النشر: | Springer Science and Business Media LLC, 2002. |
| سنة النشر: | 2002 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Adolescent, Endothelium, Hyperlipidemias, chemistry.chemical_compound, Risk Factors, Internal medicine, Hyperlipidemia, medicine, Humans, Endothelial dysfunction, Child, Probability, Greece, Triglyceride, Cell adhesion molecule, Cholesterol, business.industry, Body Weight, Cholesterol, HDL, Cholesterol, LDL, medicine.disease, medicine.anatomical_structure, Endocrinology, chemistry, Pediatrics, Perinatology and Child Health, Regression Analysis, Female, business, Cell Adhesion Molecules, Body mass index, Selectin |
| الوصف: | Cell adhesion molecules play a rather important role in the development of atherosclerosis mediating the attachment of monocytes to the endothelium. It has also been well established that hyperlipidemia is a risk factor for atherosclerosis from childhood. The aim of this study was to investigate whether the soluble adhesion molecules correlate with the circulating lipid levels in children. The study population consisted of 107 children (64 boys, 43 girls) aged 6-13 y. Parental history of cardiovascular disease, age, gender, and anthropometric parameters were recorded in all children. Blood samples were obtained from every child following a 12-hour fasting period. Serum triglycerides, total cholesterol, and its fractions as well as plasma levels of P and E selectins and adhesion molecules sVCAM-1 and sICAM-1 were determined. After controlling for age and body mass index, both sVCAM-1 and sP-selectin levels were inversely associated with HDL values (r = -0.33, p = 0.005 and r = -0.39, p = 0.001, respectively). A significant positive correlation was found between sVCAM-1 and triglycerides (r = 0.48, p < 0.001). An increment of 10 mg/dL of HDL corresponds to about 50% reduction of the odds for endothelial dysfunction whereas an increment of 10 mg/dL of triglyceride levels indicates a more than 3-fold excess risk, using either sP-selectin or sVCAM-1 levels as a surrogate for the determination of endothelial dysfunction. We suggest that HDL-C and triglycerides correlate in a biologically plausible way with soluble adhesion molecules, which therefore could be considered as useful indicators of the process of preclinical atherosclerosis even from childhood. |
| تدمد: | 1530-0447 0031-3998 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89e0a8ab0e8f0a5ede7c4f10ceee499fTest https://doi.org/10.1203/00006450-200209000-00025Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....89e0a8ab0e8f0a5ede7c4f10ceee499f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15300447 00313998 |
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