دورية أكاديمية
Phagosomal signalling of the C-type lectin receptor Dectin-1 is terminated by intramembrane proteolysis
| العنوان: | Phagosomal signalling of the C-type lectin receptor Dectin-1 is terminated by intramembrane proteolysis |
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| المؤلفون: | Mentrup, Torben, Stumpff-Niggemann, Anna Yamina, Leinung, Nadja, Schlosser, Christine, Schubert, Katja, Wehner, Rebekka, Tunger, Antje, Schatz, Valentin, Neubert, Patrick, Gradtke, Ann-Christine, Wolf, Janina, Rose-John, Stefan, Saftig, Paul, Dalpke, Alexander, Jantsch, Jonathan, Schmitz, Marc, Fluhrer, Regina, Jacobsen, Ilse D., Schröder, Bernd |
| حالة النشر: | publishedVersion |
| بيانات النشر: | Springer Nature, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Original Material: | urn:nbn:de:bsz:14-qucosa2-914191 |
| مصطلحات موضوعية: | Antimicrobial responses, Fungal infection, Lysosomes, Pattern recognition receptors, Phagocytosis, Antimikrobielle Reaktionen, Pilzinfektion, Lysosomen, Mustererkennungsrezeptoren, Phagozytose, info:eu-repo/classification/ddc/500, ddc:500 |
| الوصف: | Sensing of pathogens by pattern recognition receptors (PRR) is critical to initiate protective host defence reactions. However, activation of the immune system has to be carefully titrated to avoid tissue damage necessitating mechanisms to control and terminate PRR signalling. Dectin-1 is a PRR for fungal β-glucans on immune cells that is rapidly internalised after ligand-binding. Here, we demonstrate that pathogen recognition by the Dectin-1a isoform results in the formation of a stable receptor fragment devoid of the ligand binding domain. This fragment persists in phagosomal membranes and contributes to signal transduction which is terminated by the intramembrane proteases Signal Peptide Peptidase-like (SPPL) 2a and 2b. Consequently, immune cells lacking SPPL2b demonstrate increased anti-fungal ROS production, killing capacity and cytokine responses. The identified mechanism allows to uncouple the PRR signalling response from delivery of the pathogen to degradative compartments and identifies intramembrane proteases as part of a regulatory circuit to control anti-fungal immune responses. |
| Original Identifier: | oai:qucosa:de:qucosa:91419 |
| نوع الوثيقة: | Article |
| اللغة: | English |
| تدمد: | 2041-1723 |
| العلاقة: | 1880; info:eu-repo/grantAgreement/Deutsche Forschungsgemeinschaft/SFB 877: Proteolyse als regulatorisches Ereignis in der Pathophysiologie/125440785//Charakterisierung der in vivo Funktionen der Signal-peptide-peptidase-like 2 Intramembranproteasen/B07; info:eu-repo/grantAgreement/Deutsche Forschungsgemeinschaft/FOR 2290: Intramembrane Proteolyse Verstehen/263531414/ |
| DOI: | 10.1038/s41467-022-29474-3 |
| الإتاحة: | https://tud.qucosa.de/id/qucosa%3A91419Test https://tud.qucosa.de/api/qucosa%3A91419/attachment/ATT-0Test/ |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsndl.DRESDEN.oai.qucosa.de.qucosa.91419 |
| قاعدة البيانات: | Networked Digital Library of Theses & Dissertations |
Full Text Finder | تدمد: | 20411723 |
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| DOI: | 10.1038/s41467-022-29474-3 |