نتائج البحث - "Antibodies, Viral -- biosynthesis"

1

Broad dengue neutralization in mosquitoes expressing an engineered antibody

المؤلفون: Chun-Hong Chen, Stephanie Gamez, James E. Crowe, Prasad N. Paradkar, Jean-Bernard Duchemin, Igor Antoshechkin, Shin-Wei Wang, Anna Buchman, Omar S. Akbari, Shin-Hang Lee, Ming Li, Melissa J. Klein

المساهمون: Section of Cell and Developmental Biology, University of California [San Diego] (UC San Diego), University of California-University of California, Division of Biology and Biological Engineering [Pasadena, USA] (BBE), California Institute of Technology (CALTECH), National Tsing Hua University [Hsinchu] (NTHU), National Mosquito-Borne Diseases Control Research Center [Taiwan], National Health Research Institutes [Taiwan] (NHRI), National Institute of Infectious Diseases and Vaccinology [Taiwan] (NHRI-IV), CSIRO Health and Biosecurity [Australia], Commonwealth Scientific and Industrial Research Organisation [Canberra] (CSIRO), Australian Centre for Disease Preparedness - Australian Animal Health Laboratory [Australia] (ACDP), Vanderbilt University Medical Center [Nashville], Vanderbilt University [Nashville], Tata Institute for Genetics and Society's [La Jolla] (TIGS), University of California-University of California-Tata Institute for Fundamental Research (TIFR)-Institute for Stem Cell Biology and Regenerative Medicine [Bengaluru, India], This work was supported in part by a Defense Advanced Research Project Agency (DARPA) Safe Genes Program Grant (HR0011-17-2- 0047) awarded to O.S.A. and a NIH Exploratory/Developmental Research Grant Award (1R21AI123937) awarded to O.S.A and CSIRO internal funding to P.N.P. The funders had no role in study design, data collection, analysis, the decision to publish, nor the preparation of the manuscript, Suthar, Mehul

المصدر: PLoS Pathogens
PLoS Pathogens, Public Library of Science, 2020, 16 (1), pp.e1008103. ⟨10.1371/journal.ppat.1008103⟩
PLoS Pathogens, Vol 16, Iss 4, p e1008545 (2020)
PLoS Pathogens, Vol 16, Iss 1, p e1008103 (2020)
PLoS pathogens, vol 16, iss 4
PLoS pathogens, vol 16, iss 1

مصطلحات موضوعية: 0106 biological sciences, Serotype, Male, MESH: Broadly Neutralizing Antibodies / immunology, MESH: Aedes / virology, Dengue virus, Pathology and Laboratory Medicine, Antibodies, Viral, Protein Engineering, 01 natural sciences, Biochemistry, Neutralization, 0302 clinical medicine, Mosquito, Dengue transmission, MESH: Animals, Vector (molecular biology), Biology (General), 0303 health sciences, Denv serotypes, Philosophy, 030302 biochemistry & molecular biology, Eukaryota, virus diseases, Limiting, 3. Good health, MESH: Protein Engineering, Blood, Medical Microbiology, MESH: Broadly Neutralizing Antibodies / genetics, Viral Pathogens, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Engineering and Technology, Antibody, Infection, QH301-705.5, Immunology, Bioengineering, Plasmid construction, Monoclonal antibody, Microbiology, 03 medical and health sciences, Biodefense, Genetics, Humans, Saliva, Microbial Pathogens, Molecular Biology, MESH: Humans, Flaviviruses, Prevention, Organisms, Biology and Life Sciences, Proteins, Correction, Dengue Virus, biochemical phenomena, metabolism, and nutrition, medicine.disease, Invertebrates, Virology, Insect Vectors, Vector-Borne Diseases, [SDV.BA.ZI]Life Sciences [q-bio]/Animal biology/Invertebrate Zoology, 010602 entomology, Species Interactions, Molecular biology techniques, Genetic engineering, Parasitology, Immunologic diseases. Allergy, MESH: Female, Developmental Biology, RNA viruses, Life Cycles, MESH: Antibodies, Viral / immunology, Physiology, viruses, Disease Vectors, medicine.disease_cause, Mosquitoes, Dengue fever, Dengue, Larvae, Aedes, Immune Physiology, Medicine and Health Sciences, Viral, 030212 general & internal medicine, Immune System Proteins, Transmission (medicine), Body Fluids, Insects, Infectious Diseases, Viruses, MESH: Antibodies, Viral / biosynthesis, Female, Anatomy, Pathogens, Research Article, Biotechnology, Arthropoda, medicine.drug_class, MESH: Antibodies, Viral / genetics, MESH: Dengue Virus / immunology, Aedes aegypti, Biology, DNA construction, Antibodies, Vaccine Related, Rare Diseases, parasitic diseases, medicine, Animals, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, 030304 developmental biology, [SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, RC581-607, biology.organism_classification, MESH: Single-Chain Antibodies / genetics, MESH: Male, Research and analysis methods, Emerging Infectious Diseases, Good Health and Well Being, MESH: Aedes / genetics, MESH: Broadly Neutralizing Antibodies / biosynthesis, biology.protein, Broadly Neutralizing Antibodies, Single-Chain Antibodies