دورية أكاديمية
Role of tumor cell pyroptosis in anti-tumor immunotherapy
| العنوان: | Role of tumor cell pyroptosis in anti-tumor immunotherapy |
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| المؤلفون: | Lincheng Zhang, Haotian Bai, Jing Zhou, Lilin Ye, Leiqiong Gao |
| المصدر: | Cell Insight, Vol 3, Iss 3, Pp 100153- (2024) |
| بيانات النشر: | Elsevier, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Biology (General) LCC:Medicine (General) |
| مصطلحات موضوعية: | Tumor cell pyroptosis, Tumor microenvironment, Immunotherapy, Anti-PD-1/PD-L1 ICB, Biology (General), QH301-705.5, Medicine (General), R5-920 |
| الوصف: | Peripheral tumor-specific CD8+ T cells often fail to infiltrate into tumor parenchyma due to the immunosuppression of tumor microenvironment (TME). Meanwhile, a significant portion of tumor-specific CD8+ T cells infiltrated into TME are functionally exhausted. Despite the enormous success of anti-PD-1/PD-L1 immune-checkpoint blockade (ICB) treatment in a wide variety of cancer types, the majority of patients do not respond to this treatment largely due to the failure to efficiently drive tumor-specific CD8+ T cell infiltration and reverse their exhaustion states. Nowadays, tumor cell pyroptosis, a unique cell death executed by pore-forming gasdermin (GSDM) family proteins dependent or independent on inflammatory caspase activation, has been shown to robustly promote immune-killing of tumor cells by enhancing tumor immunogenicity and altering the inflammatory state in the TME, which would be beneficial in overcoming the shortages of anti-PD-1/PD-L1 ICB therapy. Therefore, in this review we summarize the current progresses of tumor cell pyroptosis in enhancing immune function and modulating TME, which synergizes anti-PD-1/PD-L1 ICB treatment to achieve better anti-tumor effect. We also enumerate several strategies to better amply the efficiency of anti-PD-1/PD-L1 ICB therapy by inducing tumor cell pyroptosis. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2772-8927 |
| العلاقة: | http://www.sciencedirect.com/science/article/pii/S2772892724000087Test; https://doaj.org/toc/2772-8927Test |
| DOI: | 10.1016/j.cellin.2024.100153 |
| الوصول الحر: | https://doaj.org/article/847676e75c594a9ea4244035fe0f8d95Test |
| رقم الانضمام: | edsdoj.847676e75c594a9ea4244035fe0f8d95 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 27728927 |
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| DOI: | 10.1016/j.cellin.2024.100153 |