Physiologic variations of serum tumor markers in gynecological malignancies during pregnancy: a systematic review
| العنوان: | Physiologic variations of serum tumor markers in gynecological malignancies during pregnancy: a systematic review |
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| المؤلفون: | Sileny Han, Frédéric Amant, Kristel Van Calsteren, Mina Mhallem Gziri, Anouk Lotgerink, Myriam Hanssens |
| المساهمون: | UCL - (SLuc) Service d'obstétrique |
| المصدر: | BMC Medicine BMC Medicine, Vol. 10, no.1, p. 86 (2012) BMC Medicine, Vol 10, Iss 1, p 86 (2012) |
| بيانات النشر: | Springer Nature |
| مصطلحات موضوعية: | Anti-Mullerian Hormone, medicine.medical_specialty, human epididymis secretory protein 4 (HE4), Genital Neoplasms, Female, lcsh:Medicine, CA 15-3, Physiology, Breast Neoplasms, inhibin B, chemistry.chemical_compound, Breast cancer, CA 125, Antigens, Neoplasm, Pregnancy, Internal medicine, Lactate dehydrogenase, medicine, Biomarkers, Tumor, cancer, Humans, Inhibins, Cervical cancer, Medicine(all), biology, L-Lactate Dehydrogenase, business.industry, lcsh:R, Cancer, Anti-Müllerian hormone, lactate dehydrogenase, General Medicine, medicine.disease, Endocrinology, anti-Müllerian hormone, squamous-cell carcinoma antigen tumor markers, chemistry, Tumor Markers, Biological, biology.protein, Female, business, Ovarian cancer, Pregnancy Complications, Neoplastic, Research Article |
| الوصف: | Background Recent insights provide support for the treatment of cancer during pregnancy, a coincidence that poses both mother and fetus at risk. Our aim was to critically review studies on the physiologic variations during pregnancy, the most common tumor markers used in diagnosis and follow-up of gynecological cancers. Methods We conducted a systematic review of six tumor markers during normal pregnancy: carbohydrate antigen (CA) 15-3 (breast cancer); squamous cell carcinoma antigen (cervical cancer); and CA 125, anti-Müllerian hormone, inhibin B and lactate dehydrogenase (ovarian cancer). Results For CA 15-3, 3.3% to 20.0% of all measurements were above the cut-off (maximum 56 U/mL in the third trimester). Squamous cell carcinoma antigen values were above cut-off in 3.1% and 10.5% of the measurements (maximum 4.3 µg/L in the third trimester). Up to 35% of CA 125 levels were above cut-off: levels were highest in the first trimester, with a maximum value up to 550 U/mL. Inhibin B, anti-Müllerian hormone and lactate dehydrogenase levels were not elevated in maternal serum during normal pregnancy. Conclusion During normal pregnancy, tumor markers including CA 15.3, squamous cell carcinoma antigen and CA 125 can be elevated; inhibin B, anti-Müllerian hormone and lactate dehydrogenase levels remain below normal cut-off values. Knowledge of physiological variations during pregnancy can be clinically important when managing gynecological cancers in pregnant patients. |
| وصف الملف: | Electronic |
| اللغة: | English |
| تدمد: | 1741-7015 |
| DOI: | 10.1186/1741-7015-10-86 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a3236bb2aad2950716e25b5512339d6Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2a3236bb2aad2950716e25b5512339d6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17417015 |
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| DOI: | 10.1186/1741-7015-10-86 |