المؤلفون: Douglas G. Johns, Louis-Charles Campeau, Puja Banka, An Bautmans, Tjerk Bueters, Elisabetta Bianchi, Danila Branca, Paul G. Bulger, Inne Crevecoeur, Fa-Xiang Ding, Robert M. Garbaccio, Erik D. Guetschow, Yan Guo, Sookhee N. Ha, Jennifer M. Johnston, Hubert Josien, Eunkyung A. Kauh, Kenneth A. Koeplinger, Jeffrey T. Kuethe, Eseng Lai, Christine L. Lanning, Anita Y.H. Lee, Li Li, Anilkumar G. Nair, Edward A. O’Neill, S. Aubrey Stoch, David A. Thaisrivongs, Thomas J. Tucker, Petr Vachal, Kristien van Dyck, Frederic P. Vanhoutte, Bram Volckaert, Dennis G. Wolford, Andy Xu, Tian Zhao, Dan Zhou, Susan Zhou, Xiaohong Zhu, Hratch J. Zokian, Abbas Walji, Harold B. Wood

المصدر: Circulation.

مصطلحات موضوعية: Physiology (medical), Cardiology and Cardiovascular Medicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::6f19bd0c61c330917293f0ae4cf3d908Test
https://doi.org/10.1161/circulationaha.122.063372Test

المؤلفون: Ying Zhai, De-Yi Yang, Ernest Asante-Appiah, Lei Chen, Haiqun Tang, Paul Ingravallo, Amin A. Nomeir, John P. Caldwell, Ling Tong, Guowei Zhou, Wensheng Yu, Yueheng Jiang, Oleg Selyutin, Anilkumar G. Nair, Seong Heon Kim, Rong Liu, Joseph A. Kozlowski, Qingbei Zeng, Stuart B. Rosenblum, Michael P. Dwyer, Rong Kong, Ellen Xia, Sony Agrawal, Robert Mazzola, Bandarpalle B. Shankar, Kerry Keertikar

المصدر: Bioorganic & Medicinal Chemistry Letters. 28:1954-1957

مصطلحات موضوعية: 0301 basic medicine, Genotype, Proline, Silylation, viruses, Clinical Biochemistry, Pharmaceutical Science, Hepacivirus, Viral Nonstructural Proteins, Pharmacology, Virus Replication, Antiviral Agents, Heterocyclic Compounds, 4 or More Rings, Biochemistry, 03 medical and health sciences, Dogs, 0302 clinical medicine, Cytochrome P-450 Enzyme System, Pharmacokinetics, Drug Discovery, Animals, Humans, Potency, NS5A, Molecular Biology, Chemistry, Organic Chemistry, virus diseases, Haplorhini, biochemical phenomena, metabolism, and nutrition, digestive system diseases, In vitro, Rats, Regimen, 030104 developmental biology, Molecular Medicine, 030211 gastroenterology & hepatology, Half-Life

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dd2480c8ed858188f3382243eccdd83Test
https://doi.org/10.1016/j.bmcl.2018.03.049Test

المؤلفون: Lei Chen, Ling Tong, Joseph A. Kozlowski, Sony Agrawal, Christian L. Holst, Bin Zhong, Yueheng Jiang, Oleg Selyutin, Craig A. Coburn, A. Samuel Vellekoop, Frederick C. Lahser, James I. Fells, Bin Hu, Patricia McMonagle, Donna Carr, Ernest Asante-Appiah, Laura Rokosz, Rong Liu, Gregory Scott Martin, Anilkumar G. Nair, Michael P. Dwyer, Stuart B. Rosenblum, Paul Ingravallo, Michael Wong, Tao Ji, Wensheng Yu, Bancha Vibulbhan, Stephanie Curry, Qingbei Zeng

المصدر: Bioorganic & Medicinal Chemistry Letters. 26:3793-3799

مصطلحات موضوعية: 0301 basic medicine, Macrocyclic Compounds, Stereochemistry, Hepacivirus, 030106 microbiology, Clinical Biochemistry, Pharmaceutical Science, Microbial Sensitivity Tests, Viral Nonstructural Proteins, Virus Replication, Antiviral Agents, Heterocyclic Compounds, 4 or More Rings, Biochemistry, Structure-Activity Relationship, 03 medical and health sciences, Drug Discovery, medicine, NS5A, Molecular Biology, Dose-Response Relationship, Drug, Molecular Structure, biology, Drug discovery, Organic Chemistry, virus diseases, Hepatitis C, medicine.disease, biology.organism_classification, Virology, digestive system diseases, In vitro, Titer, Regimen, 030104 developmental biology, Viral replication, Molecular Medicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff0f63a0987e007812c5ee3e770f1ad2Test
https://doi.org/10.1016/j.bmcl.2016.05.042Test

المؤلفون: Ling Tong, Craig A. Coburn, Michael P. Dwyer, Paul Ingravallo, Stephanie Curry, Mingxiang Lin, Guowei Zhou, Stuart B. Rosenblum, Shuai Zan, Wensheng Yu, Joseph A. Kozlowski, Ying Zhai, Oleg Selyutin, Bin Hu, Michael Wong, Lei Chen, Rong Liu, Ernest Asante-Appiah, Qingbei Zeng, Jinglai Hao, Seong Heon Kim, Anilkumar G. Nair, Ellen Xia, Tao Ji, Patricia McMonagle, Frédéric Massé, Bin Zhong, Sony Agrawal

المصدر: Bioorganic & Medicinal Chemistry Letters. 26:3414-3420

مصطلحات موضوعية: Male, 0301 basic medicine, Elbasvir, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Hepacivirus, Microbial Sensitivity Tests, Viral Nonstructural Proteins, Antiviral Agents, 01 natural sciences, Biochemistry, Rats, Sprague-Dawley, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Drug Discovery, Animals, Potency, Structure–activity relationship, HCV NS5A Inhibitor, NS5A, Molecular Biology, Benzofurans, Indole test, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Aryl, Organic Chemistry, Imidazoles, virus diseases, digestive system diseases, Rats, 0104 chemical sciences, 030104 developmental biology, chemistry, Aminal, Molecular Medicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f844a35f493581f923c107e7306f3e35Test
https://doi.org/10.1016/j.bmcl.2016.06.056Test

المؤلفون: Sony Agrawal, Bin Hu, Deyou Sha, Rebecca T. Ruck, Tao Ji, Rong Liu, Bin Zhong, Wensheng Yu, Ian W. Davies, Kung-I Feng, Patricia McMonagle, Shuai Zan, Lei Chen, Ellen Xia, Laura L. Rokosz, Robert Mazzola, Frederick C. Lahser, Jingjun Yin, Stephanie Curry, Karin Bystol, Donna Carr, Ernest Asante-Appiah, Oleg Selyutin, Shiying Chen, Anilkumar G. Nair, Mark Cartwright, Jae-Hun Kim, Jinglai Hao, Paul Ingravallo, Ling Tong, Joseph A. Kozlowski, Michael P. Dwyer

المصدر: Journal of medicinal chemistry. 60(1)

مصطلحات موضوعية: 0301 basic medicine, Pyrrolidines, viruses, Mutant, Hepacivirus, Pharmacology, Viral Nonstructural Proteins, Bioinformatics, Antiviral Agents, Heterocyclic Compounds, 4 or More Rings, Cell Line, 03 medical and health sciences, Structure-Activity Relationship, 0302 clinical medicine, Dogs, Drug Discovery, Genotype, Animals, Humans, HCV NS5A Inhibitor, NS5A, Indole test, Polymorphism, Genetic, Chemistry, virus diseases, Haplorhini, biochemical phenomena, metabolism, and nutrition, digestive system diseases, Rats, Regimen, Thiazoles, 030104 developmental biology, Molecular Medicine, 030211 gastroenterology & hepatology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abe0bd68f384386862060afb21e674b7Test
https://pubmed.ncbi.nlm.nih.gov/27808515Test

المؤلفون: Bin Hu, Ling Tong, Sony Agrawal, Craig A. Coburn, Bandarpalle B. Shankar, Michael P. Dwyer, Bin Zhong, Lei Chen, Shiying Chen, Seong Heon Kim, Stuart B. Rosenblum, Shuai Zan, Karin Bystol, Ian W. Davies, Donna Carr, Ernest Asante-Appiah, Wensheng Yu, Joseph A. Kozlowski, Rebecca T. Ruck, Patricia McMonagle, Anilkumar G. Nair, Rong Liu, Oleg Selyutin, De-Yi Yang, Paul Ingravallo, Tao Ji, Qingbei Zeng, Jinglai Hao, Stephanie Curry, Frederick C. Lahser

المصدر: Bioorganicmedicinal chemistry letters. 26(21)

مصطلحات موضوعية: 0301 basic medicine, Indoles, Proline, Stereochemistry, viruses, Clinical Biochemistry, Pharmaceutical Science, Viral Nonstructural Proteins, 01 natural sciences, Biochemistry, Antiviral Agents, 03 medical and health sciences, Structure-Activity Relationship, Drug Discovery, HCV NS5A Inhibitor, Replicon, NS5A, Molecular Biology, Benzofurans, Indole test, Chemistry, Organic Chemistry, Imidazoles, virus diseases, biochemical phenomena, metabolism, and nutrition, digestive system diseases, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 030104 developmental biology, Molecular Medicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a60cb16436bbb67d5e33f8fd3f828fe7Test
https://pubmed.ncbi.nlm.nih.gov/27680588Test

المؤلفون: Stuart B. Rosenblum, Stephen Gavalas, Francisco Velazquez, Pinto Patrick A, Oleg Selyutin, Neng-Yang Shih, Yuhua Huang, Wanli Wu, Sony Agrawal, Yueheng Jiang, Srikanth Venkatraman, Joseph A. Kozlowski, Chuan-kui Jiang, Hsueh-Cheng Huang, Jose S. Duca, Anilkumar G. Nair, Bancha Vibulbhan, Eric Ferrari, Kevin X. Chen, Cheng Li, Charles A. Lesburg, F. George Njoroge, Frank Bennett, Qingbei Zeng

المصدر: Bioorganic & Medicinal Chemistry. 21:2007-2017

مصطلحات موضوعية: Indoles, Hepatitis C virus, Clinical Biochemistry, Pharmaceutical Science, RNA-dependent RNA polymerase, Hepacivirus, Crystallography, X-Ray, medicine.disease_cause, Antiviral Agents, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, RNA polymerase, Drug Discovery, medicine, Humans, Replicon, Binding site, Molecular Biology, NS5B, Polymerase, chemistry.chemical_classification, Binding Sites, biology, Organic Chemistry, virus diseases, RNA-Dependent RNA Polymerase, Hepatitis C, Virology, digestive system diseases, Molecular Docking Simulation, Enzyme, chemistry, biology.protein, Molecular Medicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f016854d014a0a4d91a3500623598032Test
https://doi.org/10.1016/j.bmc.2013.01.024Test

المؤلفون: Rong Kong, Wensheng Yu, Paul Ingravallo, Bin Hu, Ling Tong, Richard Soll, Joseph A. Kozlowski, Stuart B. Rosenblum, Rong Liu, James I. Fells, Ellen Xia, Oleg Selyutin, Craig A. Coburn, Peter T. Meinke, Sony Agrawal, Lei Chen, Amin A. Nomeir, Bin Zhong, Ernest Asante-Appiah, Michael P. Dwyer, Anilkumar G. Nair, Ying Zhai, Yueheng Jiang

المصدر: Bioorganicmedicinal chemistry letters. 26(20)

مصطلحات موضوعية: 0301 basic medicine, MK-8742, Indoles, Stereochemistry, 030106 microbiology, Clinical Biochemistry, Mutant, Pharmaceutical Science, Hepacivirus, Viral Nonstructural Proteins, Biochemistry, Antiviral Agents, Elbasvir, 03 medical and health sciences, HCV infection treatment, Drug Discovery, HCV NS5A Inhibitor, NS5A, Molecular Biology, DAA, Indole test, Chemistry, Tetracyclic core, Organic Chemistry, virus diseases, digestive system diseases, HCV NS5A inhibitor, 030104 developmental biology, Direct-acting antiviral agents, Molecular Medicine, Function (biology)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c44dc14e3baf5b21019c48ab0792245Test
https://pubmed.ncbi.nlm.nih.gov/27634194Test

المؤلفون: Guowei Zhou, Ling Tong, Bandarpalle B. Shankar, De-Yi Yang, Rong Liu, Sony Agrawal, Ying Zhai, Rong Kong, Craig A. Coburn, Lei Chen, Qingbei Zeng, Seong Heon Kim, Brian J. Lavey, Kerry Keertikar, Razia Rizvi, Ellen Xia, Michael Wong, Yueheng Jiang, Stuart B. Rosenblum, Wensheng Yu, Ernest Asante-Appiah, Anilkumar G. Nair, Joseph A. Kozlowski, Paul Ingravallo, Amin A. Nomeir, Michael P. Dwyer, Oleg Selyutin

المصدر: Bioorganicmedicinal chemistry letters. 26(16)

مصطلحات موضوعية: 0301 basic medicine, Indoles, Genotype, Hepacivirus, Clinical Biochemistry, Pharmaceutical Science, Viral Nonstructural Proteins, Biochemistry, Antiviral Agents, 03 medical and health sciences, Structure-Activity Relationship, Drug Discovery, Area under curve, Structure–activity relationship, Animals, NS5A, Molecular Biology, Indole test, biology, Chemistry, Organic Chemistry, virus diseases, biology.organism_classification, Virology, digestive system diseases, Rats, 030104 developmental biology, ROC Curve, Area Under Curve, Molecular Medicine, Half-Life

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d95943f585472c6925fcc6867075afb6Test
https://pubmed.ncbi.nlm.nih.gov/27423481Test

المؤلفون: Patricia McMonagle, Sony Agrawal, Stuart B. Rosenblum, Ling Tong, Wensheng Yu, Paul Ingravallo, Bandarpalle B. Shankar, Guowei Zhou, Oleg Selyutin, Razia Rizvi, Bin Zhong, Frederick C. Lahser, Rong Liu, Brian J. Lavey, De-Yi Yang, Stephanie Curry, Craig A. Coburn, Laura Rokosz, Michael P. Dwyer, Joseph A. Kozlowski, Lei Chen, Amin A. Nomeir, Donna Carr, Ernest Asante-Appiah, Yueheng Jiang, Anilkumar G. Nair, Seong Heon Kim, Qingbei Zeng, Jinglai Hao, Michael Wong, Bin Hu

المصدر: Bioorganicmedicinal chemistry letters. 26(15)

مصطلحات موضوعية: 0301 basic medicine, Male, Elbasvir, viruses, Clinical Biochemistry, Pharmaceutical Science, Hepacivirus, Microbial Sensitivity Tests, Pharmacology, Viral Nonstructural Proteins, Virus Replication, 01 natural sciences, Biochemistry, Antiviral Agents, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Drug Discovery, Potency, Structure–activity relationship, Animals, NS5A, Molecular Biology, Benzofurans, Indole test, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Organic Chemistry, Imidazoles, virus diseases, biochemical phenomena, metabolism, and nutrition, Virology, Hepatitis C, digestive system diseases, In vitro, 0104 chemical sciences, Rats, Titer, 030104 developmental biology, chemistry, Aminal, Molecular Medicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d736ae1eea6333cd6ded142d2f518f6Test
https://pubmed.ncbi.nlm.nih.gov/27282742Test