Oligodendroglial Tumors: Refinement of Candidate Regions on Chromosome Arm 1p and Correlation of 1p/19q Status with Survival
| العنوان: | Oligodendroglial Tumors: Refinement of Candidate Regions on Chromosome Arm 1p and Correlation of 1p/19q Status with Survival |
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| المؤلفون: | Angelika Erkwoh, Rolf Fimmers, Otmar D. Wiestler, Lutz Kirsch, Guido Reifenberger, Uwe Schlegel, Jörg Felsberg, Britta Blaschke, Johannes Schramm, Michael Sabel |
| المصدر: | Brain Pathol 55. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), 1. Joint Meeting mit der Ungarischen Gesellschaft für Neurochirurgie; 20040425-20040428; Köln; DOCP 06.59 /20040423/ |
| بيانات النشر: | Blackwell Publishing Ltd, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Oncology, Adult, Male, medicine.medical_specialty, Pathology, Adolescent, medicine.medical_treatment, Oligodendroglioma, Loss of Heterozygosity, Biology, Astrocytoma, Polymerase Chain Reaction, Pathology and Forensic Medicine, Loss of heterozygosity, Internal medicine, medicine, Humans, Oligodendroglial Tumor, Child, Survival rate, neoplasms, Survival analysis, Aged, Aged, 80 and over, Chemotherapy, Brain Neoplasms, General Neuroscience, Chromosome, Middle Aged, medicine.disease, Prognosis, Survival Analysis, Survival Rate, ddc: 610, Chromosomes, Human, Pair 1, Chromosome Arm, Disease Progression, Female, Neurology (clinical), Research Article, Microsatellite Repeats |
| الوصف: | Loss of heterozygosity (LOH) on the chromosome arms 1p and 19q is frequent in oligodendroglial tumors and has been correlated with chemosensitivity and good prognosis in anaplastic oligodendrogliomas. The oligodendroglioma‐associated tumor suppressor genes on 1p and 19q are as yet unknown. To narrow down candidate regions on 1p, we investigated oligodendroglial tumors from 89 patients for LOH at up to 30 polymorphic loci on 1p. In addition, all tumors were studied for LOH at 7 loci on 19q. Combined LOH on 1p and 19q was detected in 20 (83%) of 24 oligodendrogliomas, 15 (63%) of 24 anaplastic oligodendrogliomas, 10 (56%) of 18 oligoastrocytomas, and 12 (52%) of 23 anaplastic oligoastrocytomas. Five tumors demonstrated partial deletions on 1p, which allowed to define 3 distinct candidate regions at 1 p36.31 ‐pter distal to D1S2633, 1p36.22‐p36.31 between D1S489 and D1S2642, and 1p34.2‐p36.1 between D1S2743 and D1S482, respectively. No partial deletions were detected on 19q. Combined LOH on 1p and 19q was associated with prolonged time to progression (TTP), longer overall survival (OS), and a higher 5‐year survival rate. Depending on the presence or absence of combined LOH on 1p and 19q, patients with anaplastic oligodendroglial tumors treated with adjuvant radio‐ and/or chemotherapy showed a median TTP of 86 months versus 39 months, a median OS of 91 months versus 46 months, and a 5‐year survival rate of 80% versus 36%, respectively. Similarly, LOH on 1p and 19q was associated with longer survival in patients with low‐grade oligodendroglial tumors (TTP: 57 months versus 47 months; OS: 172 months versus 105 months; 5‐year survival rate: 92% versus 70%). Thus, our results refine the location of putative oligodendroglioma suppressor genes on 1p and support the significance of LOH on 1p and 19q as a favorable prognostic marker. |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16c06e94aa57b0b8832512d969bfe4dcTest https://europepmc.org/articles/PMC8095961Test/ |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....16c06e94aa57b0b8832512d969bfe4dc |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |