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1
المؤلفون: Shiying Chen, Wensheng Yu, Joseph A. Kozlowski, Daniel Lundell, Seong Heon Kim, Ling Tong, Shelby Umland, Xiaoda Niu, Vinay Girijavallabhan, Lei Chen, Aneta Kosinski, Guowei Zhou, Mengwei Hu, Neng-Yang Shih, Bandarpalle B. Shankar, De-Yi Yang
المصدر: Bioorganic & Medicinal Chemistry Letters. 27:3704-3708
مصطلحات موضوعية: 0301 basic medicine, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Hydantoin, ADAM17 Protein, Pharmacology, Biochemistry, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Dogs, Drug Discovery, Animals, Humans, Potency, Prodrugs, Pentanoic Acids, Molecular Biology, Whole blood, chemistry.chemical_classification, Hydantoins, Organic Chemistry, Haplorhini, Prodrug, Tace inhibitor, Rats, Enzyme Activation, 030104 developmental biology, Enzyme, ROC Curve, chemistry, Area Under Curve, Molecular Medicine, Lead compound, Half-Life
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5125137f478242040971d76ea3dc87f8Test
https://doi.org/10.1016/j.bmcl.2017.07.007Test -
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المؤلفون: Guowei Zhou, Liping Yang, Neng-Yang Shih, M. Arshad Siddiqui, Vinay Girijavallabhan, Shiying Chen, Lei Chen, Dansu Li, Peter Orth, Zhuyan Guo, Bandarpalle B. Shankar, Kristin E. Rosner, Wensheng Yu, Ling Tong, Chaoyang Dai, Joseph A. Kozlowski, Aneta Kosinski, Xiaoda Niu, Seong Heon Kim, Daniel Lundell, Shelby Umland, Janeta Popovici-Muller
المصدر: Bioorganic & Medicinal Chemistry Letters. 27:3037-3042
مصطلحات موضوعية: 0301 basic medicine, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Hydantoin, ADAM17 Protein, Biochemistry, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Dogs, 0302 clinical medicine, Drug Discovery, Animals, Humans, Potency, Protease Inhibitors, Molecular Biology, Whole blood, chemistry.chemical_classification, Chemistry, Hydantoins, Organic Chemistry, Haplorhini, Rats, Enzyme Activation, 030104 developmental biology, Enzyme, ROC Curve, Area Under Curve, Molecular Medicine, Tumor necrosis factor alpha, Half-Life, 030215 immunology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e9ae78bb60384e5c554a062fa84b16eTest
https://doi.org/10.1016/j.bmcl.2017.05.062Test -
3
المؤلفون: Ashok Arasappan, Seong-Heon Kim, Robert C. Reynolds, Cheng Li, Aneta Kosinski, Jeremy Clark, Joseph A. Kozlowski, Ling Tong, Vinay Girijavallabhan, Pinto Patrick A, Lei Chen, F. George Njoroge, Anita T. Fowler, Vishal Verma, Subramaniam Ananthan, Randall R. Rossman, Robert Chase, Neng-Yang Shih, Joseph A. Maddry, John A. Secrist, Cecil D. Kwong, Hollis S. Kezar, Abhijit Roychowdhury, Stephanie Curry, Malcolm MacCoss, Hsueh-Cheng Huang, Razia Rizvi, Frank Bennett, Stephen Gavalas, Yuhua Huang, Francisco Velazquez, Alvarez Carmen S, Feng Geng, Xiao Tong, John J. Piwinski, Regina Huelgas, Bandarpalle B. Shankar, Srikanth Venkatraman
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:3229-3234
مصطلحات موضوعية: Pyrimidine, Stereochemistry, Clinical Biochemistry, Substituent, Pharmaceutical Science, Rodentia, Hepacivirus, Virus Replication, Antiviral Agents, Methylation, Biochemistry, Residue (chemistry), chemistry.chemical_compound, Dogs, Species Specificity, In vivo, Drug Discovery, Animals, Potency, Moiety, Benzothiazoles, Replicon, Molecular Biology, Chemistry, Organic Chemistry, Haplorhini, Pyrimidines, Benzothiazole, Molecular Medicine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63e593455015b9cae754dc9b1385747bTest
https://doi.org/10.1016/j.bmcl.2012.03.036Test -
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المؤلفون: Liping Yang, Shelby Umland, Peter Orth, Daniel Lundell, Luke Firmansjah, Feltz Robert, Chaoyang Dai, Joseph A. Kozlowski, Wensheng Yu, Janeta Popovici-Muller, Seong Heon Kim, Vincent S. Madison, John J. Piwinski, De-Yi Yang, M. Arshad Siddiqui, Ling Tong, Xiaoda Niu, Brian J. Lavey, Guowei Zhou, Banderpalle B. Shankar, Razia Rizvi, Kristin E. Rosner, Neng-Yang Shih, Aneta Kosinski, Hong Bian, Dansu Li, Vinay Girijavallabhan, Lei Chen, Himanshu Shah, Zhuyan Guo, Jing Sun, Wong Michael K C
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:7283-7287
مصطلحات موضوعية: medicine.medical_treatment, Clinical Biochemistry, Anti-Inflammatory Agents, Pharmaceutical Science, Hydantoin, ADAM17 Protein, Pharmacology, Biochemistry, Arthritis, Rheumatoid, chemistry.chemical_compound, Dogs, Drug Discovery, medicine, Animals, Humans, Protease Inhibitors, Molecular Biology, Whole blood, chemistry.chemical_classification, biology, Acetylene, Organic Chemistry, Biological activity, Haplorhini, In vitro, Rats, ADAM Proteins, Cytokine, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Tumor necrosis factor alpha
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f13e3eb17b7abab77da7bd68ad794d7Test
https://doi.org/10.1016/j.bmcl.2010.10.081Test -
5
المؤلفون: Bandarpalle B. Shankar, Ling Tong, Himanshu Shah, Wensheng Yu, Jing Sun, De-Yi Yang, Guowei Zhou, Lei Chen, Feltz Robert, Kristin E. Rosner, Xiaoda Niu, Neng-Yang Shih, Shelby Umland, Zhuyan Guo, John J. Piwinski, Seong Heon Kim, Dansu Li, Razia Rizvi, Peter Orth, Aneta Kosinski, Wong Michael K C, Joseph A. Kozlowski, Daniel Lundell, M. Arshad Siddiqui, Brian J. Lavey
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:5286-5289
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Hydantoin, ADAM17 Protein, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Hydrolase, Animals, Structure–activity relationship, Enzyme Inhibitors, Molecular Biology, biology, Organic Chemistry, Active site, Biological activity, Rats, ADAM Proteins, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Selectivity
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0544f42865077bfcb9c1747073ba2311Test
https://doi.org/10.1016/j.bmcl.2010.06.134Test -
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المؤلفون: Cecil D. Kwong, Stephanie Curry, John A. Secrist, Vinay Girijavallabhan, Pinto Patrick A, Lei Chen, Hsueh-Cheng Huang, Aneta Kosinski, Razia Rizvi, Robert C. Reynolds, Ling Tong, Ashok Arasappan, F. George Njoroge, Subramaniam Ananthan, Frank Bennett, Joseph A. Kozlowski, Vishal Verma, Joseph A. Maddry, Hollis S. Kezar, Malcolm MacCoss, Yuhua Huang, Namita Bansal, Francisco Velazquez, Randall R. Rossman, Xiao Tong, Stephen Gavalas, Seong-Heon Kim, Cheng Li, Robert Chase, Bandarpalle B. Shankar, Srikanth Venkatraman
المصدر: Bioorganicmedicinal chemistry letters. 22(22)
مصطلحات موضوعية: Pyrimidine, Stereochemistry, Clinical Biochemistry, High selectivity, Carbohydrates, Pharmaceutical Science, Biological Availability, Hepacivirus, Virus Replication, Biochemistry, Antiviral Agents, chemistry.chemical_compound, Structure-Activity Relationship, Dogs, Drug Discovery, Animals, Molecular Biology, Geminal, Organic Chemistry, Haplorhini, Rats, Pyrimidines, chemistry, Plasma exposure, Molecular Medicine, Half-Life
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08a6f48b123a123044b72874916a54d0Test
https://pubmed.ncbi.nlm.nih.gov/23036957Test -
7
المؤلفون: Jacob Valiyaveettil, Vinay Girijavallabhan, Pinto Patrick A, Lei Chen, Seong-Heon Kim, Anita T. Fowler, Cecil D. Kwong, Neng-Yang Shih, Xiao Tong, Cheng Li, Frank Bennett, Namita Bansal, Joseph A. Maddry, Hsueh-Cheng Huang, Subramaniam Ananthan, Ling Tong, Stephanie Curry, Joseph A. Kozlowski, Malcolm MacCoss, Srikanth Venkatraman, Francisco Velazquez, Hollis S. Kezar, Bandarpalle B. Shankar, Alvarez Carmen S, Vishal Verma, Randall R. Rossman, John J. Piwinski, Yuhua Huang, Robert C. Reynolds, Stephen Gavalas, Razia Rizvi, Robert Chase, Aneta Kosinski, Ashok Arasappan, John A. Secrist, Jeremy Clark, F. George Njoroge
المصدر: Bioorganicmedicinal chemistry letters. 22(17)
مصطلحات موضوعية: Pyrimidine, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, RNA-dependent RNA polymerase, Hepacivirus, Ring (chemistry), Virus Replication, Biochemistry, Antiviral Agents, chemistry.chemical_compound, Structure-Activity Relationship, Dogs, Drug Discovery, Potency, Molecule, Animals, Humans, Molecular Biology, Glyceraldehyde 3-phosphate dehydrogenase, biology, Organic Chemistry, Hepatitis C, Rats, Thiazoles, Pyrimidines, chemistry, Benzothiazole, biology.protein, Molecular Medicine, Selectivity
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12b8f85f4ca4fda22394ea622aca8cb0Test
https://pubmed.ncbi.nlm.nih.gov/22858143Test