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1دورية أكاديمية
المؤلفون: Liqi He, Meng Yao Zhang, Matthew Cox, Qian Zhang, Andrew F. Donnell, Yong Zhang, Christine Tarby, Patrice Gill, Murugaiah A. M. Subbaiah, Thangeswaran Ramar, Maheswara Reddy, Vijaya Puttapaka, Yi-Xin Li, Prasanna Sivaprakasam, David Critton, Dawn Mulligan, Chunshan Xie, Radha Ramakrishnan, Jignesh Nagar, Shailesh Dudhgaonkar, Anwar Murtaza, Martins S. Oderinde, Gary L. Schieven, Arvind Mathur, Ashvinikumar V. Gavai, Gregory Vite, Sanjeev Gangwar, Yam B. Poudel
مصطلحات موضوعية: Biochemistry, Medicine, Pharmacology, Immunology, Cancer, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, synergistic antitumor activity, promising therapeutic agents, phenylpiperidine side chain, gathered considerable interest, novel tlr7 agonists, adme properties culminated, 14 b, vivo <, like properties, 7 agonists, suggesting opportunities, pharmacodynamic profiles, oncology therapies, like receptor, favorable drug, demonstrated excellent, cancer immunotherapy, apd1 antibody, additional refinement
الإتاحة: https://doi.org/10.1021/acsmedchemlett.3c00456.s001Test
https://figshare.com/articles/journal_contribution/Identification_and_Optimization_of_Small_Molecule_Pyrazolopyrimidine_TLR7_Agonists_for_Applications_in_Immuno-oncology/24968292Test -
2دورية أكاديمية
المؤلفون: Yam B. Poudel, Liqi He, Matthew Cox, Qian Zhang, Walter L. Johnson, Qiang Cong, Heng Cheng, Naidu S. Chowdari, Christine Tarby, Andrew F. Donnell, Matthais Broekema, Daniel P. O’Malley, Yong Zhang, Murugaiah A. M. Subbaiah, Boda Vijay Kumar, Lakshumanan Subramani, Bei Wang, Yi-Xin Li, Prasanna Sivaprakasam, David Critton, Dawn Mulligan, Bhupindar Sandhu, Chunshan Xie, Radha Ramakrishnan, Jignesh Nagar, Shailesh Dudhgaonkar, Martins S. Oderinde, Anwar Murtaza, Gary L. Schieven, Arvind Mathur, Ashvinikumar V. Gavai, Gregory Vite, Sanjeev Gangwar
مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Pharmacology, Biotechnology, Immunology, Cancer, Computational Biology, Chemical Sciences not elsewhere classified, mouse whole blood, complete tumor regression, 26 tumor model, based reporter assay, selective tlr7 agonists, novel tlr7 agonists, tlr7 agonists, developed novel, based designs, vitro <, tnfα cytokines, systemic agent, significant secretion, pharmacodynamic studies, mice showed, intravenous route
الإتاحة: https://doi.org/10.1021/acsmedchemlett.3c00455.s001Test
https://figshare.com/articles/journal_contribution/Discovery_of_Novel_TLR7_Agonists_as_Systemic_Agent_for_Combination_With_aPD1_for_Use_in_Immuno-oncology/24961448Test -
3دورية أكاديمية
المؤلفون: Yong Zhang (5893), Karen E. Parrish (10168575), David R. Tortolani (11613326), Michael A. Poss (362043), Audris Huang (1436374), Honghe Wan (1551430), Ashok V. Purandare (1551415), Andrew F. Donnell (1893616), James Kempson (1665415), Xiaoping Hou (3225315), Joseph Pawluczyk (4435993), Shiuhang Yip (1402564), Emily Luk (4230610), Nimmi Raghavan (11613329), Jesse Swanson (5877005), James Smalley (3224205), Anwar Murtaza (6508505), Zheng Yang (264955), Karen Augustine-Rauch (5877014), Louis J. Lombardo (1551439), Robert Borzilleri (2102530)
مصطلحات موضوعية: Biochemistry, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, serine protease substrate, reduced systemic exposure, prolonged favorable increase, 10 b, 1 b, tumor efficacy comparable, tissue distribution studies, tgfβr inhibitor inhibition, tumor tissues relative, tumor tissues, acting tumor, weekly administration, thereby widen, therapeutic index, tgfβ signaling, tgfβ receptor, selectively metabolized, selective compound, provided anti, provide improved, parent compound, mouse models
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المؤلفون: Anthony N. Cauley, Antonio Ramirez, Chandan L. Barhate, Andrew F. Donnell, Purnima Khandelwal, Melda Sezen-Edmonds, Trevor C. Sherwood, Jack L. Sloane, Cullen L. Cavallaro, Eric M. Simmons
المصدر: Organic Letters. 24:5663-5668
مصطلحات موضوعية: Organic Chemistry, Physical and Theoretical Chemistry, Biochemistry
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::d9ee29c296f8c1915554eaf382950346Test
https://doi.org/10.1021/acs.orglett.2c01942Test -
5
المؤلفون: Shiuhang Yip, Emily Luk, Anwar Murtaza, Yong Zhang, Michael A. Poss, Louis J. Lombardo, Nimmi Raghavan, Zheng Yang, James Kempson, Audris Huang, David R. Tortolani, Jesse Swanson, Xiaoping Hou, Joseph Pawluczyk, James Smalley, Honghe Wan, Karen E. Parrish, Robert M. Borzilleri, Ashok V. Purandare, Karen Augustine-Rauch, Andrew F. Donnell
المصدر: Journal of Medicinal Chemistry. 64:15787-15798
مصطلحات موضوعية: Drug, media_common.quotation_subject, Receptor, Transforming Growth Factor-beta Type I, Antineoplastic Agents, Pharmacology, Small Molecule Libraries, Mice, Immune system, Therapeutic index, Drug Stability, Neoplasms, Drug Discovery, Animals, Humans, Prodrugs, Tissue Distribution, Receptor, media_common, Serine protease, Mice, Inbred BALB C, Molecular Structure, biology, Chemistry, Myocardium, Prodrug, Xenograft Model Antitumor Assays, Small molecule, Blockade, Mice, Inbred C57BL, Area Under Curve, biology.protein, Molecular Medicine, Female, Half-Life
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aebde71751ab18259045cb79ccd54677Test
https://doi.org/10.1021/acs.jmedchem.0c02043Test -
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المؤلفون: Anthony N, Cauley, Antonio, Ramirez, Chandan L, Barhate, Andrew F, Donnell, Purnima, Khandelwal, Melda, Sezen-Edmonds, Trevor C, Sherwood, Jack L, Sloane, Cullen L, Cavallaro, Eric M, Simmons
المصدر: Organic letters. 24(31)
مصطلحات موضوعية: Bromides, Nickel, Quinolines, Esters, Catalysis
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::a50ac435d4868eaaf4a621fbc0c33528Test
https://pubmed.ncbi.nlm.nih.gov/35920644Test -
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المؤلفون: Cullen L. Cavallaro, Merrill L. Davies, E. Scott Priestley, Fukang Yang, Chandan L. Barhate, Yong Zhang, Harold N. Weller, G. Greg Zipp, Andrew F. Donnell, Regina Black, Yingru Zhang, Ling Li
المصدر: Chemical communications (Cambridge, England). 57(84)
مصطلحات موضوعية: Miniaturization, Material consumption, business.industry, Computer science, Metals and Alloys, General Chemistry, Catalysis, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, High-Throughput Screening Assays, Small Molecule Libraries, Workflow, Tandem Mass Spectrometry, Materials Chemistry, Ceramics and Composites, Process engineering, business, Throughput (business), Microscale chemistry, Chromatography, High Pressure Liquid, Delay time
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee291c401f71b21201f45f5a630f5e1aTest
https://pubmed.ncbi.nlm.nih.gov/34608906Test -
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المؤلفون: Yufen Zhao, Barri Wautlet, Jonathan Lippy, Anne Rose, Andrew J. Tebben, Gregory D. Vite, Max Ruzanov, Joseph Fargnoli, Liping Zhang, Yong Zhang, Zheng Yang, Karen E. Parrish, Robert M. Borzilleri, Yi Fan, Jesse Swanson, Ching-Ping Ho, Karen Augustine-Rauch, Andrew F. Donnell, Brian E. Fink, Steven Sheriff, Mark Fereshteh
مصطلحات موضوعية: 0301 basic medicine, Antitumor immunity, biology, business.industry, Kinase, medicine.medical_treatment, Organic Chemistry, Biochemistry, Blockade, 03 medical and health sciences, 030104 developmental biology, Cytokine, Immune system, Murine tumor, Drug Discovery, Cancer research, biology.protein, Medicine, Antibody, business, Receptor
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dca61cd13f527f4d17df3df6c932c4f3Test
https://europepmc.org/articles/PMC6231184Test/ -
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المؤلفون: Erik M. Stang, Heidi L. Perez, Andrew F. Donnell, Robert M. Borzilleri, Gregory D. Vite, Yong Zhang, Sanjeev Gangwar, Chetana Rao, Donna D. Wei, Andrew J. Tebben, Gretchen M. Schroeder, Chin Pan
المصدر: Bioorganicmedicinal chemistry letters. 27(23)
مصطلحات موضوعية: Antibody-drug conjugate, Macrocyclic Compounds, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Pyrrolobenzodiazepine, Antineoplastic Agents, 010402 general chemistry, 01 natural sciences, Biochemistry, Antibodies, chemistry.chemical_compound, Benzodiazepines, Structure-Activity Relationship, Cell Line, Tumor, Drug Discovery, Potency, Structure–activity relationship, Humans, Pyrroles, Solubility, Molecular Biology, Cell Proliferation, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Organic Chemistry, Combinatorial chemistry, In vitro, 0104 chemical sciences, chemistry, Molecular Medicine, Cancer cell lines, Drug Screening Assays, Antitumor, Dimerization, Conjugate
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac419ef64e8db777dc7d66e410cec16eTest
https://pubmed.ncbi.nlm.nih.gov/29102228Test -
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المصدر: The Journal of organic chemistry. 81(21)
مصطلحات موضوعية: Alanine, Aldehydes, 010405 organic chemistry, Chemistry, Proton Magnetic Resonance Spectroscopy, Organic Chemistry, Synthon, chemistry.chemical_element, Stereoisomerism, Ketones, 010402 general chemistry, 01 natural sciences, Mass Spectrometry, 0104 chemical sciences, Adduct, Aldol reaction, beta-Alanine, Organic chemistry, Azetidines, Stereoselectivity, Lithium, Carbon-13 Magnetic Resonance Spectroscopy
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cb4011f3c3c310c008223d4d9f323cbTest
https://pubmed.ncbi.nlm.nih.gov/27627106Test