دورية أكاديمية
Immunoglobulin A antibodies against myelin oligodendrocyte glycoprotein in a subgroup of patients with central nervous system demyelination
| العنوان: | Immunoglobulin A antibodies against myelin oligodendrocyte glycoprotein in a subgroup of patients with central nervous system demyelination |
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| المؤلفون: | Ayroza Galvão Ribeiro Gomes, A.B., Kulsvehagen, L., Lipps, P., Cagol, A., Cerdá-Fuertes, N., Neziraj, T., Flammer, J., Lerner, J., Lecourt, A.C., de Oliveira S Siebenborn, N., Cortese, R., Schaedelin, S., Andreoli Schoeps, V., de Moura Brasil Matos, A., Trombini Mendes, N., Dos Reis Pereira, C., Ribeiro Monteiro, M.L., Dos Apóstolos-Pereira, S.L., Schindler, P., Chien, C., Schwake, C., Schneider, R., Pakeerathan, T., Aktas, O., Fischer, U., Mehling, M., Derfuss, T., Kappos, L., Ayzenberg, I., Ringelstein, M., Paul, F., Callegaro, D., Kuhle, J., Papadopoulou, A., Granziera, C., Pröbstel, A.K. |
| بيانات النشر: | American Medical Association |
| سنة النشر: | 2023 |
| المجموعة: | Max-Delbrueck-Center for Molecular Medicine, Berlin: MDC Repository |
| مصطلحات موضوعية: | Function and Dysfunction of the Nervous System, Topic 3: Integrative Biomedicine |
| الوصف: | IMPORTANCE: Differential diagnosis of patients with seronegative demyelinating central nervous system (CNS) disease is challenging. In this regard, evidence suggests that immunoglobulin (Ig) A plays a role in the pathogenesis of different autoimmune diseases. Yet little is known about the presence and clinical relevance of IgA antibodies against myelin oligodendrocyte glycoprotein (MOG) in CNS demyelination. OBJECTIVE: To investigate the frequency of MOG-IgA and associated clinical features in patients with demyelinating CNS disease and healthy controls. DESIGN, SETTING, AND PARTICIPANTS: This longitudinal study comprised 1 discovery and 1 confirmation cohort derived from 5 centers. Participants included patients with suspected or confirmed demyelinating diseases and healthy controls. MOG-IgA, MOG-IgG, and MOG-IgM were measured in serum samples and cerebrospinal fluid (CSF) of patients, who were assessed from September 2012 to April 2022. MAIN OUTCOMES AND MEASURES: Frequency and clinical features of patients who were seropositive for MOG-IgA and double-seronegative for aquaporin 4 (AQP4) IgG and MOG-IgG. RESULTS: After the exclusion of 5 participants with coexisting AQP4-IgG and MOG-IgA, MOG-IgG, and/or MOG-IgM, 1339 patients and 110 healthy controls were included; the median follow-up time was 39 months (range, 0-227 months). Of included patients with isolated MOG-IgA, 11 of 18 were female (61%), and the median age was 31.5 years (range, 3-76 years). Among patients double-seronegative for AQP4-IgG and MOG-IgG (1126/1339; 84%), isolated MOG-IgA was identified in 3 of 50 patients (6%) with neuromyelitis optica spectrum disorder, 5 of 228 patients (2%) with other CNS demyelinating diseases, and 10 of 848 patients (1%) with multiple sclerosis but in none of the healthy controls (0/110). The most common disease manifestation in patients seropositive for isolated MOG-IgA was myelitis (11/17 [65%]), followed by more frequent brainstem syndrome (7/16 [44%] vs 14/75 [19%], respectively; P = .048), and infrequent ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf; other |
| اللغة: | English |
| العلاقة: | http://edoc.mdc-berlin.de/23661/1/23661oa.pdfTest; http://edoc.mdc-berlin.de/23661/7/23661suppl.zipTest; Immunoglobulin A antibodies against myelin oligodendrocyte glycoprotein in a subgroup of patients with central nervous system demyelination. Ayroza Galvão Ribeiro Gomes, A.B. and Kulsvehagen, L. and Lipps, P. and Cagol, A. and Cerdá-Fuertes, N. and Neziraj, T. and Flammer, J. and Lerner, J. and Lecourt, A.C. and de Oliveira S Siebenborn, N. and Cortese, R. and Schaedelin, S. and Andreoli Schoeps, V. and de Moura Brasil Matos, A. and Trombini Mendes, N. and Dos Reis Pereira, C. and Ribeiro Monteiro, M.L. and Dos Apóstolos-Pereira, S.L. and Schindler, P. and Chien, C. and Schwake, C. and Schneider, R. and Pakeerathan, T. and Aktas, O. and Fischer, U. and Mehling, M. and Derfuss, T. and Kappos, L. and Ayzenberg, I. and Ringelstein, M. and Paul, F. and Callegaro, D. and Kuhle, J. and Papadopoulou, A. and Granziera, C. and Pröbstel, A.K. JAMA Neurology 80 (9): 989-995. September 2023 |
| DOI: | 10.1001/jamaneurol.2023.2523 |
| الإتاحة: | https://doi.org/10.1001/jamaneurol.2023.2523Test http://edoc.mdc-berlin.de/23661Test/ https://edoc.mdc-berlin.de/23661Test/ http://edoc.mdc-berlin.de/23661/1/23661oa.pdfTest http://edoc.mdc-berlin.de/23661/7/23661suppl.zipTest |
| حقوق: | cc_by_4 |
| رقم الانضمام: | edsbas.2984A74A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1001/jamaneurol.2023.2523 |
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