دورية أكاديمية
Relationship of Cytokine Status Parameters with the Lipid Peroxidation-Antioxidant Defense System in Obese Adolescents
| العنوان: | Relationship of Cytokine Status Parameters with the Lipid Peroxidation-Antioxidant Defense System in Obese Adolescents |
|---|---|
| المؤلفون: | Marina A. Darenskaya, Lyubov V. Rychkova, Natalya V. Semenova, Zhanna V. Prokhorova, Olga A. Tugarinova, Tatyana A. Mityukova, Anastasia A. Basalai, Olga E. Poluliakh, Lyubov I. Kolesnikova |
| المصدر: | International Journal of Biomedicine, Vol 13, Iss 3, Pp 79-83 (2023) |
| بيانات النشر: | International Medical Research and Development Corporation, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | interleukins, adolescents, lipid peroxidation, obesity, Medicine |
| الوصف: | The aim of this study was to identify the relationships between cytokine status, lipid peroxidation (LPO) products, and total antioxidant activity (TAA) in obese adolescent boys and girls. Methods and Results: The study included 29 boys and 33 girls with an established diagnosis of exogenous-constitutional obesity of the first degree. Twenty-eight healthy adolescent boys and 24 adolescent girls made up control groups. The concentration of cytokines (IL-6, IL-8, IL-4, and IL-10) was assessed by enzyme immunoassay. The content of LPO products (conjugated dienes [CDs], ketodienes and conjugated trienes [KD-CT], Schiff bases [SB], thiobarbituric acid reactants [TBARs], total antioxidant activity (TAA) was evaluated. Spectrophotometric methods were used. The data obtained indicated a statistically significant increase in the level of IL-6 (P=0.018) and the IL-6/IL10 ratio (P=0.033) in obese boys, compared with the control. There was also an increase in the content of LPO products in this group relative to the control group: KD-CT (P=0.043) and SB (P=0.021). In the group of obese girls, there was an increase in IL-6 values (P=0.018), a decrease in IL-4 (P=0.040), and an increase in CDs (P=0.035) and KD-CT (P=0.044). The following correlations were found in the control group of boys: CDs‒KD-CT (r=0.91; P=0.001), TBARS‒IL-8 (r=0.73; P=0.027), and SB‒IL-4 (r=0.79; P=0.011); there were no statistically significant correlations between study parameters in obese boys. The following correlations were recorded in the girls of the control group: CDs‒KD-CT (r=0.99; P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2158-0510 2158-0529 |
| العلاقة: | http://www.ijbm.org/articles/i51/ijbm_13Test(3)_oa4.pdf; https://doaj.org/toc/2158-0510Test; https://doaj.org/toc/2158-0529Test |
| DOI: | 10.21103/Article13(3)_OA4 |
| الوصول الحر: | https://doaj.org/article/83148bc84c124913a01969fc32d63e24Test |
| رقم الانضمام: | edsdoj.83148bc84c124913a01969fc32d63e24 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 21580510 21580529 |
|---|---|
| DOI: | 10.21103/Article13(3)_OA4 |