Biweekly fluctuations of neuropsychiatric symptoms according to the Neuropsychiatric Inventory: Erratic symptoms or scores?
| العنوان: | Biweekly fluctuations of neuropsychiatric symptoms according to the Neuropsychiatric Inventory: Erratic symptoms or scores? |
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| المؤلفون: | Willem S. Eikelboom, Amy den Teuling, Daphne E. Pol, Michiel Coesmans, Sanne Franzen, Lize C. Jiskoot, Judy van Hemmen, Ellen H. Singleton, Rik Ossenkoppele, Frank Jan de Jong, Esther van den Berg, Janne M. Papma |
| المساهمون: | Neurology, Psychiatry, Amsterdam Neuroscience - Neurodegeneration |
| المصدر: | International Journal of Geriatric Psychiatry, 37(7). John Wiley & Sons Ltd. Eikelboom, W S, den Teuling, A, Pol, D E, Coesmans, M, Franzen, S, Jiskoot, L C, van Hemmen, J, Singleton, E H, Ossenkoppele, R, de Jong, F J, van den Berg, E & Papma, J M 2022, ' Biweekly fluctuations of neuropsychiatric symptoms according to the Neuropsychiatric Inventory : Erratic symptoms or scores? ', International Journal of Geriatric Psychiatry, vol. 37, no. 7 . https://doi.org/10.1002/gps.5770Test International Journal of Geriatric Psychiatry, 37(7). John Wiley and Sons Ltd |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Male, Psychiatry and Mental health, Caregivers, SDG 3 - Good Health and Well-being, Alzheimer Disease, mental disorders, Humans, Dementia, Female, Neuropsychological Tests, Geriatrics and Gerontology, humanities, Aged |
| الوصف: | Objectives: This study investigates the stability of neuropsychiatric symptoms (NPS) assessed biweekly using the Neuropsychiatric Inventory (NPI) in a memory clinic population during a 6 week period. Methods: Twenty-three spousal caregivers (mean [SD] age = 69.7 [8.8], 82.6% female) of 23 patients (43.5% had dementia) completed all assessments. The NPI was assessed four times during 6 weeks. We examined whether NPI domains were present during all four assessments, studied within-person variation for each NPI domain, and calculated Spearman's correlations between subsequent time-points. Furthermore, we associated repeated NPI assessments with repeated measures of caregiver burden to examine the clinical impact of changes in NPI scores over time. Results: The course of NPS was highly irregular according to the NPI, with only 35.8% of the NPI domains that were present at baseline persisted during all 6 weeks. We observed large within-person variation in the presence of individual NPI domains (61.3%, range 37.5%–83.9%) and inconsistent correlations between NPI assessments (e.g., range r s = 0.20–0.57 for agitation, range r s = 0.29–0.59 for anxiety). Higher NPI total scores were related to higher caregiver burden (r s = 0.60, p s = 0.16, p = 0.20). Conclusions: We observed strong fluctuations in NPI scores within very short time windows raising the question whether this represents erratic symptoms and/or scores. Further studies are needed to investigate the origins of these fluctuations. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0885-6230 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e7389bcf3a32253fe825ffcec4c7fd7Test https://pure.eur.nl/en/publications/38e7f68c-e8f1-4390-a4bb-5934f81b6504Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6e7389bcf3a32253fe825ffcec4c7fd7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 08856230 |
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