دورية أكاديمية
Leaf-buds of Pistacia atlantica: a novel source of bioactive molecules with high anti-inflammatory, antioxidant, anti-tyrosinase and antimicrobial properties
| العنوان: | Leaf-buds of Pistacia atlantica: a novel source of bioactive molecules with high anti-inflammatory, antioxidant, anti-tyrosinase and antimicrobial properties |
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| المؤلفون: | Benmahieddine A., Belyagoubi-Benhammou N., Belyagoubi L., Amari N. O., Zerey-Belaskri A. E., Gismondi A., Di Marco G., Canini A., Habi S., Atik Bekkara F., Djebli N. |
| المساهمون: | Benmahieddine, A, Belyagoubi-Benhammou, N, Belyagoubi, L, Amari, No, Zerey-Belaskri, Ae, Gismondi, A, Di Marco, G, Canini, A, Habi, S, Atik Bekkara, F, Djebli, N |
| بيانات النشر: | Springer |
| سنة النشر: | 2023 |
| المجموعة: | Universitá degli Studi di Roma "Tor Vergata": ART - Archivio Istituzionale della Ricerca |
| مصطلحات موضوعية: | Biological activities, HPLC–DAD, Hydro-methanolic extract, Leaf-bud, Phenolic compound, Pistacia atlantica, Settore BIO/01 - BOTANICA GENERALE, Settore BIO/04, Settore BIO/10, Settore BIO/11, Settore BIO/14 |
| الوصف: | In this study, for the first time, the anti-inflammatory, antioxidant, anti-tyrosinase and antimicrobial property of P. atlantica Desf. subsp. atlantica leaf-bud extracthave been investigated. The anti-inflammatory activity was determined in vivo by reducing carrageenan-induced hind paw edema in mice, while the antiradical function was evaluated using DPPH, total antioxidant capacity (TAC) and reduction power assays. The extract induced a significant reduction of the edema, from 1 to 6h in a dose-dependent manner (150, 200 and 300mg/kg). Histological observations of the inflamed tissues also confirmed this. An effective antioxidant activity of the plant samples was demonstrated, showing an EC50 = 0.183 ± 0.005mg/mL for the DPPH test, a value of 28.776 ± 2.541mg AAE/g for the TAC and an EC50 = 0.136 ± 0.003mg/mL for reducing power. The leaf-bud extract also revealed a good antimicrobial activity against S. aureus and L. monocytogenes (mean diameter of inhibition zones of 13.2 and 17.0mm, respectively), while a slight antifungal effect was observed. The plant preparation was then documented to inhibit tyrosinase activity, with an EC50 value of 0.098 ± 0.00mg/mL in a dose-dependent manner. HPLC–DAD analysis revealed that dimethyl-allyl caffeic acid and rutin were the most abundant molecules. The current data documented that P. atlantica leaf-bud extract has strong biological properties and constitutes a potential source of pharmacological molecules. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/36875728; info:eu-repo/semantics/altIdentifier/wos/WOS:000926308700001; volume:29; issue:2; firstpage:209; lastpage:219; numberofpages:11; journal:PHYSIOLOGY AND MOLECULAR BIOLOGY OF PLANTS; https://hdl.handle.net/2108/324004Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85147576919 |
| DOI: | 10.1007/s12298-023-01290-z |
| الإتاحة: | https://doi.org/10.1007/s12298-023-01290-zTest https://hdl.handle.net/2108/324004Test |
| حقوق: | info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.8D643334 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s12298-023-01290-z |
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