Auto-antibodies against the angiotensin II type I receptor in women with uteroplacental acute atherosis and preeclampsia at delivery and several years postpartum
| العنوان: | Auto-antibodies against the angiotensin II type I receptor in women with uteroplacental acute atherosis and preeclampsia at delivery and several years postpartum |
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| المؤلفون: | Ralf Dechend, Anne Cathrine Staff, Gro Leite Størvold, Christopher W.G. Redman, Gerd Wallukat, Patji Alnæs-Katjavivi, Nils Bolstad, Meryam Sugulle, Amalie Bjerke Rieber-Mohn |
| المصدر: | Journal of reproductive immunology. 128 |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adult, medicine.medical_specialty, Immunology, 030204 cardiovascular system & hematology, Receptor, Angiotensin, Type 1, Preeclampsia, Lesion, 03 medical and health sciences, 0302 clinical medicine, Pre-Eclampsia, Pregnancy, Renin–angiotensin system, medicine, Decidua, Immunology and Allergy, Humans, reproductive and urinary physiology, Autoantibodies, 030219 obstetrics & reproductive medicine, business.industry, Obstetrics, Postpartum Period, Autoantibody, Obstetrics and Gynecology, medicine.disease, Atherosclerosis, Angiotensin II, female genital diseases and pregnancy complications, Reproductive Medicine, Immunohistochemistry, Female, Decidua Basalis, medicine.symptom, business |
| الوصف: | Background Uteroplacental acute atherosis is a pregnancy-specific lesion resembling early stages of atherosclerosis found frequently in preeclampsia. Preeclampsia is associated with an increased risk for future maternal atherosclerotic cardiovascular disease. The renin-angiotensin-system plays a role both in atherosclerosis and in preeclampsia. Circulating agonistic autoantibodies at the angiotensin-II type 1 receptor (AT1-AA) are increased in preeclampsia. We hypothesized an association between AT1-AA at delivery and postpartum with acute atherosis in pregnancy. Material and Methods Maternal serum and decidua basalis tissue was collected at elective cesarean section (n = 41; 24 preeclampsia, 17 normotensive controls). Circulating AT1-AA were detected by a bioassay using spontaneously beating rat cardiomyocytes at delivery (n = 41) and 5–8 years postpartum in a subgroup (n = 10). Decidual acute atherosis was assessed by immunohistochemistry. Results Significantly less normotensive controls (18%; 3/17) than women with preeclampsia (58%; 14/24) were AT1-AA positive at delivery, p |
| تدمد: | 1872-7603 0165-0378 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::702b01106a79935438d886e87d47b824Test https://pubmed.ncbi.nlm.nih.gov/29843114Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....702b01106a79935438d886e87d47b824 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18727603 01650378 |
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