المؤلفون: Silva, Aaron, Xiao, Wenwu, Wang, Yan, Wang, Wei, Chang, Heng Wei, Ames, James B, Lam, Kit S, Zhang, Yonghong

المصدر: International journal of molecular sciences. 21(9)

مصطلحات موضوعية: RGD peptides, in silico screening, in vitro binding, integrin αvβ3 antagonists, structure–activity relationship, integrin alpha v beta 3 antagonists, structure-activity relationship, Chemical Physics, Other Chemical Sciences, Genetics, Other Biological Sciences

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/9kk17902Test

المؤلفون: Sudha, Thangirala, Bharali, Dhruba J., Davis, Paul J., Mousa, Shaker A.

المساهمون: Bursa Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü., orcid:0000-0002-4177-3478, Coşkun, Melis Debreli, Çelikler, Serap, CML-2517-2022, 57194630463, 8234554800

مصطلحات موضوعية: Pancreatic cancer, NF-kappa B, Cisplatin, Alpha v beta 3 integrin receptor antagonist, Peripheral neuropathy, Motor dysfunction, Induced peripheral neurotoxicity, Tetraiodothyroacetic aicd, Multidrag-resistance, Thyroid-hormone, Alpha(v)beta(3) antagonists, Inflammatory cytokines, Targeted delivery, Oxidative stress, Drug-resistance, Pharmacology & pharmacy, Integrin, Thyroid Hormones, Nano-Diamino-Tetrac, 3 [3 [3 (4, 5 dihydroimidazol 2 ylamino)propyloxylisoxazol 5 yl]carbonylamino] 2 (phenylsulfonylamino)propionic acid, Antineoplastic agent, Interleukin 10, Immunoglobulin enhancer binding protein, Interleukin 1beta, Interleukin 6, Receptor blocking agent, Tumor necrosis factor, Unclassified drug, Vitronectin receptor

وصف الملف: application/pdf

العلاقة: 2214-A (1059B141401097); Makale - Uluslararası Hakemli Dergi; Frontiers in Pharmacology; Yurt dışı; Coşkun, M. D. vd. (2020). "Alpha v beta 3 integrin antagonists enhance chemotherapy response in an orthotopic pancreatic cancer model". Frontiers in Pharmacology, 11.; https://doi.org/10.3389/fphar.2020.00095Test; https://www.frontiersin.org/articles/10.3389/fphar.2020.00095/fullTest; http://hdl.handle.net/11452/30215Test; 000525314000001; 2-s2.0-85082498621; 11

الإتاحة: https://doi.org/10.3389/fphar.2020.00095Test
http://hdl.handle.net/11452/30215Test

المؤلفون: Wei Wang, Heng Wei Chang, Yan Wang, Kit S. Lam, Yonghong Zhang, Wenwu Xiao, James B. Ames, Aaron Silva

المصدر: International Journal of Molecular Sciences, Vol 21, Iss 3076, p 3076 (2020)
International journal of molecular sciences, vol 21, iss 9
International Journal of Molecular Sciences
Volume 21
Issue 9

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Magnetic Resonance Spectroscopy, structure–activity relationship, Molecular Conformation, in silico screening, Peptide, Peptide binding, lcsh:Chemistry, 0302 clinical medicine, Models, Disulfides, integrin αvβ3 antagonists, lcsh:QH301-705.5, Spectroscopy, RGD peptides, Cancer, chemistry.chemical_classification, Cyclic, biology, Molecular Structure, General Medicine, Computer Science Applications, Amino acid, in vitro binding, Biochemistry, 030220 oncology & carcinogenesis, Oligopeptides, integrin alpha v beta 3 antagonists, Protein Binding, In silico, Integrin, Peptides, Cyclic, Article, Catalysis, Inorganic Chemistry, 03 medical and health sciences, Inhibitory Concentration 50, Structure-Activity Relationship, Genetics, Structure–activity relationship, Humans, Physical and Theoretical Chemistry, Molecular Biology, Chemical Physics, Organic Chemistry, Rational design, Molecular, Integrin alphaVbeta3, 030104 developmental biology, chemistry, lcsh:Biology (General), lcsh:QD1-999, Docking (molecular), biology.protein, Other Biological Sciences, Peptides, Other Chemical Sciences

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da61bba298735dda9f82f0591e095ee8Test
https://www.mdpi.com/1422-0067/21/9/3076Test

المؤلفون: Melis Debreli Coskun, Thangirala Sudha, Dhruba J. Bharali, Serap Celikler, Paul J. Davis, Shaker A. Mousa

المساهمون: Bursa Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü., Coşkun, Melis Debreli, Çelikler, Serap, CML-2517-2022

المصدر: Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 11 (2020)

مصطلحات موضوعية: 0301 basic medicine, peripheral neuropathy, Unclassified drug, Mouse, medicine.medical_treatment, pancreatic cancer, cisplatin, Interleukin 6, Signal transduction, Treatment response, Animal tissue, NF-κB, Interleukin 10, 0302 clinical medicine, Alpha(v)beta(3) antagonists, Pancreatic tumor, Alpha v beta 3 integrin receptor antagonist, Protein blood level, Pharmacology (medical), Cancer inhibition, Interleukin 10 blood level, Pancreas cancer, Original Research, Induced peripheral neurotoxicity, Cancer resistance, Xt 199, Interleukin 1beta, NF-kappa B, Body position, Transcription initiation, Inflammatory cytokines, Neuroprotection, Hindlimb, Cytokine, Antineoplastic agent, 030220 oncology & carcinogenesis, Female, Tumor necrosis factor alpha, Bioluminescence, Thyroid-hormone, Animal cell, Protein determination, Tumor necrosis factor blood level, motor dysfunction, medicine.drug, [[4 [4 [3 [3 [poly 2 (2 hydroxyacetotoxy)]propanamido]aminopropoxy] 3,5 diiodophenoxy] 3,5 diiodophenyl] acetic acid], Combination therapy, Tumor necrosis factor, Drug potentiation, Histopathology, Article, Proinflammatory cytokine, 03 medical and health sciences, Pancreatic cancer, medicine, Cancer model, Animal model, Animal experiment, 3 [3 [3 (4, 5 dihydroimidazol 2 ylamino)propyloxylisoxazol 5 yl]carbonylamino] 2 (phenylsulfonylamino)propionic acid, Receptor blocking agent, Interleukin 1beta blood level, SUIT2-luc cancer cell line, Drug-resistance, Antineoplastic activity, αvβ3 integrin receptor antagonist, Cisplatin, Pharmacology, Multidrag-resistance, Pharmacology & pharmacy, Tumor necrosis, business.industry, lcsh:RM1-950, Pancreatic cancer cell line, Monotherapy, Nonhuman, medicine.disease, Integrin, Thyroid Hormones, Nano-Diamino-Tetrac, Cancer combination chemotherapy, Vitronectin receptor antagonist, Drug efficacy, lcsh:Therapeutics. Pharmacology, 030104 developmental biology, Immunoglobulin enhancer binding protein, Oxidative stress, Cancer cell, Cancer research, Tetraiodothyroacetic aicd, Protein expression, Targeted delivery, Vitronectin receptor, Interleukin 6 blood level, business, Controlled study

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec93b71b364edfe0bd541004eb40a9e8Test

المؤلفون: Zhang, Cheng-Xiang, Zhao, Wei-Yu, Liu, Lei, Ju, Rui-Jun, Mu, Li-Min, Zhao, Yao, Zeng, Fan, Xie, Hong-Jun, Yan, Yan, Lu, Wan-Liang

المساهمون: Lu, WL (reprint author), Peking Univ, Sch Pharmaceut Sci, Beijing Key Lab Mol Pharmaceut & New Drug Syst, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China., Peking Univ, Sch Pharmaceut Sci, Beijing Key Lab Mol Pharmaceut & New Drug Syst, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China.

المصدر: SCI ; PubMed

مصطلحات موضوعية: Functional targeting epirubicin liposomes, BBB, brain glioblastoma, neovasculatures, mechanism and efficacy, INTEGRIN ALPHA(V)BETA(3) ANTAGONISTS, NEUROTROPHIC FACTOR, DRUG-DELIVERY, BARRIER MODEL, CANCER-CELLS, ANGIOGENESIS, GLIOMAS, RGD, TRANSPORTERS, MULTIFORME

العلاقة: ONCOTARGET.2015,6,(32),32681-32700.; 1289162; http://hdl.handle.net/20.500.11897/415662Test; WOS:000363186600046

الإتاحة: https://doi.org/20.500.11897/415662Test
https://doi.org/10.18632/oncotarget.5354Test
https://hdl.handle.net/20.500.11897/415662Test

المؤلفون: Cardillo, G, Gennari, A, Gentilucci, L, Mosconi, E, Tolomelli, A, Troisi, S

المصدر: Cardillo , G , Gennari , A , Gentilucci , L , Mosconi , E , Tolomelli , A & Troisi , S 2010 , ' Synthesis of chiral non-racemic intermediates and Arg-Gly-Asp mimetics by CaLB-catalyzed resolution ' , Tetrahedron-Asymmetry , vol. 21 , no. 1 , pp. 96-102 . https://doi.org/DOITest 10.1016/j.tetasy.2009.12.021

مصطلحات موضوعية: candida-antarctica-lipase, beta-amino acids, nonpeptide alpha(v)beta(3) antagonists, organic-solvents, biological evaluation, enzymatic resolution, rgd mimetics, stereoselective-synthesis, conformational-analysis, integrin antagonists

الإتاحة: https://doi.org/10.1016/j.tetasy.2009.12.021Test
https://research.manchester.ac.uk/en/publications/ee769fa1-66e0-4410-94af-ba5712d166c3Test

المؤلفون: Davies, S G, Smith, A D, Price, P D

المصدر: Davies , S G , Smith , A D & Price , P D 2005 , ' The conjugate addition of enantiomerically pure lithium amides as homochiral ammonia equivalents: scope, limitations and synthetic applications ' , Tetrahedron: Asymmetry , vol. 16 , no. 17 , pp. 2833-2891 . https://doi.org/10.1016/j.tetasy.2005.08.006Test

مصطلحات موضوعية: BETA-AMINO ACIDS, PARALLEL KINETIC RESOLUTION, NONPEPTIDE ALPHA(V)BETA(3) ANTAGONISTS, MEISENHEIMER REARRANGEMENT PROTOCOL, EXPEDITIOUS ASYMMETRIC-SYNTHESIS, RING CLOSING METATHESIS, CHIRAL BUILDING-BLOCK, ALPHA-HYDROXY ACIDS, IRON ACYL COMPLEXES, ENANTIOSELECTIVE SYNTHESIS

العلاقة: https://research-portal.st-andrews.ac.uk/en/researchoutput/the-conjugate-addition-of-enantiomerically-pure-lithium-amides-as-homochiral-ammonia-equivalents-scope-limitations-and-synthetic-applicationsTest(7ff3f778-8e78-4cf4-98c5-128c5d07c88b).html

الإتاحة: https://doi.org/10.1016/j.tetasy.2005.08.006Test
https://research-portal.st-andrews.ac.uk/en/researchoutput/the-conjugate-addition-of-enantiomerically-pure-lithium-amides-as-homochiral-ammonia-equivalents-scope-limitations-and-synthetic-applicationsTest(7ff3f778-8e78-4cf4-98c5-128c5d07c88b).html

المؤلفون: Belvisi, L., Riccioni, T., Marcellini, M., Vesci, L., Chiarucci, I., Efrati, D., Potenza, D., Scolastico, C., Manzoni, L., Lombardo, K., Stasi, M. A., Orlandi, A., Ciucci, A., Nico, B., Ribatti, D., Giannini, G., Presta, Marco, Carminati, P., Pisano, C.

المصدر: Molecular cancer therapeutics. 4(11)

مصطلحات موضوعية: Models, Molecular, Vascular Endothelial Growth Factor A, Integrins, Platelet Aggregation, Protein Conformation, Nude, Molecular Conformation, Crystallography, X-Ray, Ligands, in-vivo, Mice, Models, matrix metalloproteinase-2 mmp-2, Receptors, alpha(v)beta(3) antagonists, Cyclic, Tumor, Crystallography, Neovascularization, Pathologic, tumor-growth, Recombinant Proteins, Animals, Antineoplastic Agents, Arginine, Aspartic Acid, Cattle, Cell Adhesion, Cell Line, Cell Proliferation, Chickens, X-Ray, Dose-Response Relationship, Drug, Endothelium, Vascular, Fibroblast Growth Factor 2, Glycine, Guinea Pigs, Humans, Inhibitory Concentration 50, Integrin alphaVbeta3, Microcirculation, Chemical, Molecular, Monte Carlo Method, Neoplasm Transplantation, Neovascularization, Pathologic, Oligopeptides, Peptides, Protein Binding, Vitronectin, Stochastic Processes, signal-transduction, Mice, Nude, Settore MED/08 - Anatomia Patologica, Peptides, Cyclic, improves survival, Cell Line, Tumor, Receptors, Vitronectin, vitronectin receptor, beta 3, melanoma-cells, Dose-Response Relationship, Drug, cyclic rgd peptides, Models, Chemical, Endothelium, Vascular

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3e0701e20f4d399d0c899450a4d7391cTest
https://pubmed.ncbi.nlm.nih.gov/16275988Test

المؤلفون: Stavrakoudis, A., Bizos, G., Eleftheriadis, D., Kouki, A., Panou-Pomonis, E., Sakarellos-Daitsiotis, M., Sakarellos, C., Tsoukatos, D., Tsikaris, V.

مصطلحات موضوعية: cyclic non-rgd containing analogues, cystine non-rgd analogues, platelet aggregation inhibitors, cyclization on solid support, disulfide bond formation, arg-gly-asp, fibrinogen receptor antagonist, alpha(v)beta(3) antagonists, integrin alpha(iib)beta(3), secondary structure, highly potent, recognition, protein, sequence, program

العلاقة: http://olympias.lib.uoi.gr/jspui/handle/123456789/8288Test

الإتاحة: http://olympias.lib.uoi.gr/jspui/handle/123456789/8288Test

المؤلفون: George Bizos, Aggeliki Kouki, Eugenia Panou-Pomonis, Vassilios Tsikaris, Damianos Eleftheriadis, Athanassios Stavrakoudis, Constantinos Sakarellos, Demokritos C. Tsoukatos, Maria Sakarellos-Daitsiotis

مصطلحات موضوعية: integrin alpha(iib)beta(3), cyclization on solid support, Protein Conformation, Stereochemistry, Biophysics, Peptide, Platelet Glycoprotein GPIIb-IIIa Complex, In Vitro Techniques, Dihedral angle, Fibrinogen, Peptides, Cyclic, Biochemistry, Biomaterials, Structure-Activity Relationship, cyclic non-rgd containing analogues, alpha(v)beta(3) antagonists, Electrochemistry, Side chain, medicine, Humans, Molecule, Platelet, arg-gly-asp, Amino Acid Sequence, platelet aggregation inhibitors, chemistry.chemical_classification, cystine non-rgd analogues, Chemistry, disulfide bond formation, Organic Chemistry, fibrinogen receptor antagonist, secondary structure, General Medicine, highly potent, sequence, Membrane protein, Drug Design, Thermodynamics, Platelet aggregation inhibitor, program, recognition, protein, Oligopeptides, Platelet Aggregation Inhibitors, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7a5dfcda907a38532ac47d88b20fe84Test
http://olympias.lib.uoi.gr/jspui/handle/123456789/8288Test