التفاصيل البيبلوغرافية
| العنوان: |
Factors Affecting the Incidence, Progression, and Severity of COVID-19 in Type 1 Diabetes Mellitus. |
| المؤلفون: |
Ahmed, Amira S.1,2 (AUTHOR), Alotaibi, Wejdan S.3 (AUTHOR), Aldubayan, Maha A.1 (AUTHOR), Alhowail, Ahmad H.1 (AUTHOR), Al-Najjar, Amal H.4 (AUTHOR), Chigurupati, Sridevi5 (AUTHOR), Elgharabawy, Rehab M.1,6 (AUTHOR) |
| المصدر: |
BioMed Research International. 11/23/2021, p1-9. 9p. |
| مصطلحات موضوعية: |
*BLOOD sugar analysis, *THERAPEUTIC use of vitamin D, *DISEASE progression, *DRUG efficacy, *FASTING, *HOSPITALS, *GLYCOSYLATED hemoglobin, *C-reactive protein, *PROTHROMBIN time, *PARTIAL thromboplastin time, *LIVER function tests, *COVID-19, *KIDNEY function tests, *FERRITIN, *CROSS-sectional method, *TYPE 1 diabetes, *DISEASE incidence, *RETROSPECTIVE studies, *SEVERITY of illness index, *VITAMIN D, *RISK assessment, *COMPARATIVE studies, *SYMPTOMS, *BLOOD sedimentation, *LACTATE dehydrogenase, *DISEASE susceptibility, *HYDROXYCHLOROQUINE, *BLOOD cell count, *VITAMIN D deficiency, *FIBRIN fibrinogen degradation products, *COMORBIDITY, *EVALUATION, *DISEASE complications |
| مصطلحات جغرافية: |
SAUDI Arabia |
| مستخلص: |
Objectives. This study screened for factors affecting coronavirus disease 2019 (COVID-19) incidence in type 1 diabetes mellitus (T1DM) patients, appraised vitamin D's efficacy in preventing COVID-19, and assessed the effects of clinical characteristics, glycemic status, vitamin D, and hydroxychloroquine administration on COVID-19's progression and severity in T1DM patients. Methods. This retrospective research on 150 adults was conducted at Security Forces Hospital, Riyadh, KSA. Participants were allocated to three groups (50/group): control, T1DM, and T1DM with COVID-19. Participants' fasting blood glucose (FBG), glycated hemoglobin (HbA1c), complete blood count, vitamin D, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), ferritin, lactate dehydrogenase (LDH), prothrombin time, activated partial thromboplastin time, D-dimer, liver and kidney function, and hydroxychloroquine treatment were retrieved and analyzed. Results. The percentages of comorbidities and not taking hydroxychloroquine were significantly higher among T1DM patients with COVID-19 than patients with T1DM only. Mean vitamin D level was significantly lower in T1DM with COVID-19 patients than in the other two groups. Vitamin D showed a significant negative correlation with LDH, CRP, ESR, ferritin, and D-dimer, which was the most reliable predictor of COVID-19 severity in T1DM patients. Conclusion. Comorbidities and vitamin D deficiency are risk factors for COVID-19 in patients with T1DM. Patients who do not take hydroxychloroquine and have higher FBG and HbA1c levels are vulnerable to COVID-19. Vitamin D may be useful for preventing COVID-19 in T1DM patients. Comorbidities, higher FBG and HbA1c levels, not taking hydroxychloroquine, and vitamin D inadequacy elevate COVID-19 progression and severity in patients with T1DM. [ABSTRACT FROM AUTHOR] |
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