Dopamine differently modulates central cholinergic circuits in patients with Alzheimer disease and CADASIL
| العنوان: | Dopamine differently modulates central cholinergic circuits in patients with Alzheimer disease and CADASIL |
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| المؤلفون: | Piergiorgio Lochner, Raffaele Nardone, Stefan Golaszewski, Yvonne Höller, Francesco Brigo, Eugen Trinka, Alexander Kunz, Aljosha Thomschewski |
| المصدر: | Journal of Neural Transmission. 121:1313-1320 |
| بيانات النشر: | Springer Science and Business Media LLC, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | medicine.medical_specialty, Neurology, Dopamine, Dopamine Agents, CADASIL, Levodopa, Leukoencephalopathy, Alzheimer Disease, medicine, Humans, Dementia, Vascular dementia, Biological Psychiatry, Aged, Afferent Pathways, Dopaminergic, Brain, Neural Inhibition, Evoked Potentials, Motor, medicine.disease, Transcranial Magnetic Stimulation, Acetylcholine, Psychiatry and Mental health, Cholinergic, Neurology (clinical), Alzheimer's disease, Psychology, Neuroscience |
| الوصف: | Short-latency afferent inhibition (SAI) technique gives the opportunity to non-invasively test an inhibitory circuit in the human cerebral motor cortex that depends mainly on central cholinergic activity. Important SAI abnormalities have been reported in both patients with Alzheimer disease (AD) and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a model of "pure" vascular dementia (VD). Interestingly, a normalization of SAI was observed in AD after levo-dopa (L-dopa) administration. We aimed to determine whether the pharmacological manipulation of the dopaminergic system can also interfere with SAI test in CADASIL patients, compared with AD patients and healthy controls. SAI was found to be significantly reduced in both patient groups. L-Dopa significantly increased SAI in the AD patients, while it failed to restore SAI abnormality in CADASIL patients. Therefore, L-dopa-mediated changes on SAI in AD patients seem to be a specific effect. The present study supports the notion that relationship between acetylcholine and dopamine systems may be specifically abnormal in AD. L-Dopa challenge may thus be able to differentiate the patients with AD or a mixed form of dementia from those with "pure" VD. |
| تدمد: | 1435-1463 0300-9564 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d3e734c2f515cd0787c5ff216de0087Test https://doi.org/10.1007/s00702-014-1195-1Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....4d3e734c2f515cd0787c5ff216de0087 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14351463 03009564 |
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