يعرض 1 - 10 نتائج من 17 نتيجة بحث عن '"Alexandra Naß"', وقت الاستعلام: 0.69s تنقيح النتائج
  1. 1
    دورية أكاديمية
    In Search for Multi-Target Ligands as Potential Agents for Diabetes Mellitus and Its Complications—A Structure-Activity Relationship Study on Inhibitors of Aldose Reductase and Protein Tyrosine Phosphatase 1B

    المؤلفون: Rosaria Ottanà, Paolo Paoli, Mario Cappiello, Trung Ngoc Nguyen, Ilenia Adornato, Antonella Del Corso, Massimo Genovese, Ilaria Nesi, Roberta Moschini, Alexandra Naß, Gerhard Wolber, Rosanna Maccari

    المصدر: Molecules, Vol 26, Iss 2, p 330 (2021)

    مصطلحات موضوعية: multi-target ligands, diabetes mellitus, aldose reductase, protein tyrosine phosphatase 1B, 4-thiazolidinones, molecular docking, Organic chemistry, QD241-441

    وصف الملف: electronic resource

    العلاقة: https://www.mdpi.com/1420-3049/26/2/330Test; https://doaj.org/toc/1420-3049Test

    الوصول الحر: https://doaj.org/article/5dbb82913dc34a5d862083d04bc41b3cTest

    View record in DOAJ النص الكامل

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  2. 2
    An investigation on 4-thiazolidinone derivatives as dual inhibitors of aldose reductase and protein tyrosine phosphatase 1B, in the search for potential agents for the treatment of type 2 diabetes mellitus and its complications

    المؤلفون: Alexandra Naß, Paolo De Paoli, Mario Cappiello, Rosanna Maccari, Francesco Balestri, Gerhard Wolber, Antonella Del Corso, Giulia Lori, Ilenia Adornato, Rosaria Ottanà

    المصدر: Bioorganic & Medicinal Chemistry Letters. 28:3712-3720

    مصطلحات موضوعية: 0301 basic medicine, Clinical Biochemistry, 4-Thiazolidinone derivatives, Aldose reductase, Designed multiple ligands, Diabetes mellitus, Protein tyrosine phosphatase 1B, Biochemistry, Molecular Medicine, Molecular Biology, 3003, Drug Discovery3003 Pharmaceutical Science, Organic Chemistry, Pharmaceutical Science, 4-Thiazolidinone derivatives, Aldose reductase, Designed multiple ligands, Diabetes mellitus, Protein tyrosine phosphatase 1B, Biochemistry, Molecular Medicine, Molecular Biology 3003, Drug Discovery 3003 Pharmaceutical Science, Clinical Biochemistry, Organic Chemistry, Pharmacology, Ligands, Inhibitory postsynaptic potential, 01 natural sciences, Structure-Activity Relationship, 03 medical and health sciences, Aldehyde Reductase, Drug Discovery, medicine, Humans, Hypoglycemic Agents, Enzyme Inhibitors, Protein Tyrosine Phosphatase, Non-Receptor Type 1, chemistry.chemical_classification, 010405 organic chemistry, Chemistry, Type 2 Diabetes Mellitus, medicine.disease, Protein Tyrosine Phosphatase 1B, In vitro, 0104 chemical sciences, Molecular Docking Simulation, 030104 developmental biology, Enzyme, Diabetes Mellitus, Type 2, 4-thiazolidinone, Thiazolidines

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6073126821f647fa6752075bff55109aTest
    https://doi.org/10.1016/j.bmcl.2018.10.024Test


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  3. 3
    Combined chemical and biotechnological production of 20βOH-NorDHCMT, a long-term metabolite of Oral-Turinabol (DHCMT)

    المؤلفون: Xavier de la Torre, Jan Felix Joseph, Lei Chen, Francesco Botrè, Maria Kristina Parr, Alexandra Naß, Matthias Bureik, Jiaxin Liu, Anna Stoll, Gerhard Wolber

    المصدر: Journal of Inorganic Biochemistry. 183:165-171

    مصطلحات موضوعية: 0301 basic medicine, Metabolite, Urine, Anabolic androgenic steroids, Pharmacology, 01 natural sciences, Biochemistry, Gas Chromatography-Mass Spectrometry, law.invention, Inorganic Chemistry, 03 medical and health sciences, chemistry.chemical_compound, Anabolic Agents, Biotransformation, law, Schizosaccharomyces, Doping, Humans, Testosterone, Doping in Sports, chemistry.chemical_classification, Fission yeast, Whole-cell biotransformation, 010401 analytical chemistry, Yeast strain, Anabolic-Androgenic Steroids, 0104 chemical sciences, 030104 developmental biology, Enzyme, chemistry, Recombinant DNA, Biotechnology, Human cytochrome

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50080ef3d08bc4088cad84c0a048c37dTest
    https://doi.org/10.1016/j.jinorgbio.2018.02.020Test


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  4. 4
    مؤتمر
    3-ARYL-5-ARYLIDENE-2-THIOXO-4-IMIDAZOLIDINONE DERIVATIVES AS NEW PTP1B ALLOSTERIC INHIBITORS

    المؤلفون: Ilenia Adornato, Paolo Paoli, Giulia Lori, Gerhard Wolber, Alexandra Naß, Rosanna Maccari, Rosaria Ottanà

    المساهمون: Adornato, Ilenia, Paoli, Paolo, Lori, Giulia, Wolber, Gerhard, Naß, Alexandra, Maccari, Rosanna, Ottana', Rosaria

    العلاقة: ispartofbook:54TH INTERNATIONAL CONFERENCE ON MEDICINAL CHEMISTRY JULY 4-6, 2018 %7C STRASBOURG, FRANCE - INTERFACING CHEMICAL BIOLOGY AND DRUG DISCOVERY; 54TH INTERNATIONAL CONFERENCE ON MEDICINAL CHEMISTRY JULY 4-6, 2018 %7C STRASBOURG, FRANCE - INTERFACING CHEMICAL BIOLOGY AND DRUG DISCOVERY; firstpage:66; lastpage:66; numberofpages:1; http://hdl.handle.net/11570/3132073Test; WWW.SCT-ASSO.FR %7C WWW.RICT2018.ORG

    الإتاحة: http://hdl.handle.net/11570/3132073Test

    View record in BASE

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  5. 5
    دورية أكاديمية
    Design and evaluation of non-carboxylate 5-arylidene-2-thioxo-4-imidazolidinones as novel non-competitive inhibitors of protein tyrosine phosphatase 1B

    المؤلفون: Rosaria Ottanà, Paolo Paoli, Giulia Lori, Ilenia Adornato, Santo Previti, Alexandra Naß, Gerhard Wolber, Rosanna Maccari

    المساهمون: OTTANA', Rosaria, Paoli, Paolo, Lori, Giulia, ADORNATO, ILENIA, PREVITI, SANTO, Naß, Alexandra, Wolber, Gerhard, MACCARI, Rosanna

    مصطلحات موضوعية: 3-aryl-5-arylidene-2-thioxo-4-imidazolidinones, Protein tyrosine phosphatase 1B, Non-competitive inhibitors, Insulin-sensitizing agents, Cellular assays

    وصف الملف: STAMPA

    العلاقة: info:eu-repo/semantics/altIdentifier/pmid/31491569; info:eu-repo/semantics/altIdentifier/wos/WOS:000489699400017; volume:92; firstpage:1; lastpage:12; numberofpages:12; journal:BIOORGANIC CHEMISTRY; http://hdl.handle.net/11570/3148427Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85071551960

    الإتاحة: https://doi.org/10.1016/j.bioorg.2019.103211Test
    http://hdl.handle.net/11570/3148427Test

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  6. 6
    Discovery of 4-[(5-arylidene-4-oxothiazolidin-3-yl)methyl]benzoic acid derivatives active as novel potent allosteric inhibitors of protein tyrosine phosphatase 1B: In silico studies and in vitro evaluation as insulinomimetic and anti-inflammatory agents

    المؤلفون: Gerhard Wolber, Adriana Carol Eleonora Graziano, Ilenia Adornato, Venera Cardile, Rosaria Ottanà, Rosanna Maccari, Archimede Rotondo, Paolo De Paoli, Alexandra Naß, Giulia Lori

    المصدر: European Journal of Medicinal Chemistry. 127:840-858

    مصطلحات موضوعية: 0301 basic medicine, Protein Conformation, Stereochemistry, Allosteric regulation, Anti-Inflammatory Agents, protein tyrosine phosphatases, enzyme inhibitors, insulinomimetic effects, anti-inflammatory activity, molecular docking, 5-arylidene-4-thiazolidinone derivatives, Protein tyrosine phosphatase, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Allosteric Regulation, Drug Discovery, Humans, Insulin, Computer Simulation, Protein kinase B, Benzoic acid, Protein Tyrosine Phosphatase, Non-Receptor Type 1, Pharmacology, chemistry.chemical_classification, biology, Chemistry, Organic Chemistry, Hep G2 Cells, General Medicine, Benzoic Acid, In vitro, Kinetics, Insulin receptor, 030104 developmental biology, Enzyme, Biochemistry, Docking (molecular), Drug Design, 030220 oncology & carcinogenesis, biology.protein, Peptidomimetics

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b2d387709e583003f800ea08f959caeTest
    https://doi.org/10.1016/j.ejmech.2016.10.063Test


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  7. 7
    Design and evaluation of non-carboxylate 5-arylidene-2-thioxo-4-imidazolidinones as novel non-competitive inhibitors of protein tyrosine phosphatase 1B

    المؤلفون: Ilenia Adornato, Rosanna Maccari, Paolo De Paoli, Giulia Lori, Alexandra Naß, Gerhard Wolber, Santo Previti, Rosaria Ottanà

    مصطلحات موضوعية: Cell Survival, medicine.medical_treatment, Allosteric regulation, Druggability, 3-aryl-5-arylidene-2-thioxo-4-imidazolidinones, Cellular assays, Insulin-sensitizing agents, Non-competitive inhibitors, Protein tyrosine phosphatase 1B, Imidazolidines, 01 natural sciences, Biochemistry, chemistry.chemical_compound, Structure-Activity Relationship, Drug Discovery, medicine, Tumor Cells, Cultured, Humans, Hypoglycemic Agents, Carboxylate, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Protein Tyrosine Phosphatase, Non-Receptor Type 1, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Insulin, Leptin, Organic Chemistry, Cancer, Hep G2 Cells, medicine.disease, Protein Tyrosine Phosphatase 1B, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Enzyme, Drug Design, hormones, hormone substitutes, and hormone antagonists

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6da24b8595996831c82c38e4f536a33bTest
    http://hdl.handle.net/2158/1171692Test


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  8. 8
    In Search for Multi-Target Ligands as Potential Agents for Diabetes Mellitus and Its Complications—A Structure-Activity Relationship Study on Inhibitors of Aldose Reductase and Protein Tyrosine Phosphatase 1B

    المؤلفون: Roberta Moschini, Ilaria Nesi, Trung Ngoc Nguyen, Antonella Del Corso, Rosanna Maccari, Massimo Genovese, Paolo De Paoli, Ilenia Adornato, Gerhard Wolber, Rosaria Ottanà, Mario Cappiello, Alexandra Naß

    المصدر: Molecules
    Volume 26
    Issue 2
    Molecules, Vol 26, Iss 330, p 330 (2021)

    مصطلحات موضوعية: 4-thiazolidinones, Drug Evaluation, Preclinical, Pharmaceutical Science, Disease, Pharmacology, Ligands, Analytical Chemistry, Mice, 0302 clinical medicine, Drug Discovery, Enzyme Inhibitors, Non-Receptor Type 1, Aldehyde Reductase, Protein Tyrosine Phosphatase, Non-Receptor Type 1, chemistry.chemical_classification, 0303 health sciences, Chemistry, Hep G2 Cells, aldose reductase, Preclinical, Chemistry (miscellaneous), 030220 oncology & carcinogenesis, diabetes mellitus, Molecular Medicine, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::615 Pharmakologie, Therapeutik, C2C12, Aldose reductase, Diabetes mellitus, Molecular docking, Multi-target ligands, Protein tyrosine phosphatase 1B, Animals, Diabetes Mellitus, Humans, Structure-Activity Relationship, Hypoglycemic Agents, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::616 Krankheiten, multi-target ligands, Article, lcsh:QD241-441, 03 medical and health sciences, lcsh:Organic chemistry, medicine, Structure–activity relationship, Physical and Theoretical Chemistry, 030304 developmental biology, Organic Chemistry, molecular docking, medicine.disease, Enzyme, Cell culture, Drug Evaluation, Protein Tyrosine Phosphatase, protein tyrosine phosphatase 1B

    وصف الملف: application/pdf

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cc68d1010cf1de2f7cbda56990a5249Test
    https://doi.org/10.3390/molecules26020330Test


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  9. 9
    3-ARYL-5-ARYLIDENE-2-THIOXO-4-IMIDAZOLIDINONE DERIVATIVES AS NEW PTP1B ALLOSTERIC INHIBITORS

    المؤلفون: Adornato, Ilenia, Paolo, Paoli, Giulia, Lori, Gerhard, Wolber, Alexandra, Naß, Maccari, Rosanna, Ottana', Rosaria

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=od______3978::3936c85fab2104c855575dcb5f095ee6Test
    http://hdl.handle.net/11570/3132073Test


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  10. 10
    Identification of 2-thioxoimidazolidin-4-one derivatives as novel noncovalent proteasome and immunoproteasome inhibitors

    المؤلفون: Federica Mannino, Giuseppe Bruno, Rosaria Ottanà, Silvana Grasso, Santo Previti, Francesco Nicolò, Alexandra Naß, Gerhard Wolber, Ilenia Adornato, Rosanna Maccari, Maria Zappalà, Alessandra Bitto, Roberta Ettari, Federica Aliquò

    مصطلحات موضوعية: 0301 basic medicine, Proteasome Endopeptidase Complex, Clinical Biochemistry, Pharmaceutical Science, Imidazolidines, Biochemistry, Immunoproteasome, Structure-Activity Relationship, 03 medical and health sciences, Proteasome, Immunoproteasome, 5-Arylidene-2-thioxoimidazolidin-4-ones, Non-covalent inhibitors, Docking studies, Drug Discovery, Non-covalent inhibitors, Humans, Docking studies, Molecular Biology, 5-Arylidene-2-thioxoimidazolidin-4-ones, Biological evaluation, Dose-Response Relationship, Drug, Molecular Structure, Proteasome, Chemistry, Organic Chemistry, Molecular Docking Simulation, 030104 developmental biology, Docking (molecular), Molecular Medicine, Proteasome Inhibitors

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a500e1d8c94be2e46c34801803054e7Test
    http://hdl.handle.net/11570/3119303Test


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