Androgenic profiles in HIV-infected male patients on highly active anti-retroviral therapy: could this be a threat to fertility?
| العنوان: | Androgenic profiles in HIV-infected male patients on highly active anti-retroviral therapy: could this be a threat to fertility? |
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| المؤلفون: | Ahmed, A.Y., Gamde , S.M., Abubakar , S.D., Muhammad , Y., Saeed, S.A., Rimi , M.I., Umar, M., Aiyelabegan, F. |
| المصدر: | Bayero Journal of Medical Laboratory Science; Vol. 5 No. 2 (2020); 147-151 |
| بيانات النشر: | Department of Medical Laboratory Science of Bayero University, Kano, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | HIV-infected Males, Hypogonadisms, Sokoto Nigeria |
| الوصف: | Background: This study aimed to evaluate the Serum Androgenic Profiles of HIV-infected Male Patients on Highly Active Antiretroviral Therapy and those not on Active Antiretroviral Therapy in Specialist Hospital Sokoto, Nigeria. Materials and Methods: One hundred and thirty-five HIV-infected male patients were evaluated in the Department of Medicine, Specialist Hospital Sokoto Nigeria from July 2017 to March 2018 using history, baseline investigations, and CD4counts. Free testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) were measured using an overnight fasting serum sample. Patients were divided into three groups (n=45); Group A= HIV-infected male patients on HAART, Group B = HIV-infected male treatment naive patients, and Group C= HIV-negative control subjects. Data were analysed using ANOVA and Chi-square tests and p≤ 0.05 was considered statistically significant Results: The serum testosterone and CD4 counts were reduced in HIV-infected male patients on HAART and HAART naive compared to the negative control. The reduced testicular functions were substantiated by raised serum LH and FSH in HIV-infected male patients on HAART (p < 0.05) compared to the negative control. Conclusions: HIV-infections associated with low CD4 counts even among patients on Highly Active Antiretroviral Therapy may pose threat to male fertility. Keywords: HIV-infected Males; Hypogonadisms; Sokoto Nigeria |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2545-5672 2635-3792 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=78975075580c::ea83bf19c0f4845f68132158be28bed9Test https://www.ajol.info/index.php/bjmls/article/view/230414Test |
| رقم الانضمام: | edsair.78975075580c..ea83bf19c0f4845f68132158be28bed9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 25455672 26353792 |
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