التفاصيل البيبلوغرافية
| العنوان: |
Macrodomain binding compound MRS 2578 inhibits alphavirus replication |
| المؤلفون: |
Mattila, S. (Sari), Merilahti, P. (Pirjo), Wazir, S. (Sarah), Quirin, T. (Tania), Maksimainen, M. M. (Mirko M.), Zhang, Y. (Yuezhou), Xhaard, H. (Henri), Lehtiö, L. (Lari), Ahola, T. (Tero) |
| بيانات النشر: |
American Society for Microbiology |
| سنة النشر: |
2021 |
| المجموعة: |
Jultika - University of Oulu repository / Oulun yliopiston julkaisuarkisto |
| مصطلحات موضوعية: |
Alphavirus, Antiviral, Chikungunya virus, Macrodomain, Virus replication |
| الوصف: |
Alphaviruses are positive-strand RNA viruses causing febrile disease. Macrodomain-containing proteins, involved in ADP-ribose-mediated signaling, are encoded by both host cells and several virus groups, including alphaviruses. In this study, compound MRS 2578 that targets the human ADP-ribose glycohydrolase MacroD1 inhibited Semliki Forest virus production as well as viral RNA replication and replicase protein expression. The inhibitor was similarly active in alphavirus trans-replication systems, indicating that it targets the viral RNA replication stage. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| الإتاحة: |
http://urn.fi/urn:nbn:fi-fe2021122162296Test |
| حقوق: |
info:eu-repo/semantics/openAccess ; © American Society for Microbiology. |
| رقم الانضمام: |
edsbas.643523CD |
| قاعدة البيانات: |
BASE |
