دورية أكاديمية
The potential of adipokines in identifying multiple trauma patients at risk of developing multiple organ dysfunction syndrome
| العنوان: | The potential of adipokines in identifying multiple trauma patients at risk of developing multiple organ dysfunction syndrome |
|---|---|
| المؤلفون: | Haupt, Julian, Krysiak, Niels, Unger, Marina, Bogner-Flatz, Viktoria, Biberthaler, Peter, Hanschen, Marc, van Griensven, Martijn, Haug, Alexander T. |
| المصدر: | http://lobid.org/resources/99370670379406441Test#!, 26(1):38. |
| سنة النشر: | 2021 |
| المجموعة: | Publisso (ZB MED-Publikationsportal Lebenswissenschaften) |
| مصطلحات موضوعية: | Systemic Inflammatory Response Syndrome/diagnosis [MeSH], Multiple trauma, Adipokines, Resistin, Multiple Organ Failure/etiology [MeSH], Systemic Inflammatory Response Syndrome/blood [MeSH], Systemic Inflammatory Response Syndrome/etiology [MeSH], Male [MeSH], Multiple Trauma/complications [MeSH], Case-Control Studies [MeSH], Interleukin-33, Multiple organ dysfunction syndrome, Interleukin-17A, Adolescent [MeSH], Female [MeSH], Follow-Up Studies [MeSH], Multiple Organ Failure/blood [MeSH], Leptin, Adult [MeSH], Biomarkers/blood [MeSH], Humans [MeSH], Middle Aged [MeSH], Multiple organ failure, ROC Curve [MeSH], Research, Prognosis [MeSH], Young Adult [MeSH], Multiple Organ Failure/diagnosis [MeSH], Adipokines/blood [MeSH] |
| الوصف: | Background!#!Multiple organ dysfunction syndrome (MODS) and the consecutive multiple organ failure (MOF) are severe and dreaded complications with a high mortality in multiple trauma patients. The aim of this study was to investigate the potential of the adipokines leptin, resistin, interleukin-17A and interleukin-33 as possible biomarkers in the early posttraumatic inflammatory response and for identifying severely traumatized patients at risk of developing MODS.!##!Methods!#!In total, 14 multiple trauma patients with an injury severity score (ISS) ≥ 16 as well as a control group of 14 non-multiple trauma patients were included in this study and blood samples were taken at the time points 0, 6, 24, 48 and 72 h after admission. For the trauma patients, the SIRS and Denver MOF score were determined daily. The quantitative measurement of the plasma concentrations of the adipokines was performed using ELISA.!##!Results!#!In the statistical analysis, the multiple trauma patients showed statistically significant higher plasma concentrations of leptin, resistin, IL-17A and IL-33 compared to the control group. In addition, there was a statistically significant positive correlation between the concentrations of resistin, IL-17A and IL-33 and the corresponding SIRS scores and between the concentrations of resistin, IL-17A and IL-33 and the corresponding Denver MOF scores. Finally, ROC curve analysis revealed that the adipokines leptin and IL-17A are suitable diagnostic markers for the discrimination between multiple trauma patients with and without MOF.!##!Conclusions!#!Leptin and IL-17A could be suitable diagnostic markers to identify severely injured patients with a developing SIRS and MOF earlier, to adjust surgical therapy planning and intensive care. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://repository.publisso.de/resource/frl:6464387Test; https://doi.org/10.1186/s40001-021-00511-zTest; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8086117Test/ |
| DOI: | 10.1186/s40001-021-00511-z |
| الإتاحة: | https://doi.org/10.1186/s40001-021-00511-zTest https://repository.publisso.de/resource/frl:6464387Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8086117Test/ |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.EF1826E4 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s40001-021-00511-z |
|---|