Does Microalbuminuria Predict Diabetic Nephropathy?
| العنوان: | Does Microalbuminuria Predict Diabetic Nephropathy? |
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| المؤلفون: | William H. Herman, Catherine M. Zawacki, Bahman P. Tabaei, Abdul S. Al-Kassab, Liza L. Ilag |
| المصدر: | Diabetes Care. 24:1560-1566 |
| بيانات النشر: | American Diabetes Association, 2001. |
| سنة النشر: | 2001 |
| مصطلحات موضوعية: | Adult, Michigan, medicine.medical_specialty, Time Factors, Adolescent, Endocrinology, Diabetes and Metabolism, Black People, Angiotensin-Converting Enzyme Inhibitors, Blood Pressure, White People, Diabetic nephropathy, chemistry.chemical_compound, Predictive Value of Tests, Risk Factors, Diabetes mellitus, Internal medicine, Internal Medicine, medicine, Albuminuria, Humans, Diabetic Nephropathies, Longitudinal Studies, Prospective Studies, Child, Prospective cohort study, Advanced and Specialized Nursing, Creatinine, Proteinuria, business.industry, Smoking, Middle Aged, medicine.disease, Surgery, Cross-Sectional Studies, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, chemistry, Predictive value of tests, Hypertension, Cohort, Disease Progression, Microalbuminuria, medicine.symptom, business, Biomarkers, Follow-Up Studies |
| الوصف: | OBJECTIVE—To describe risk factors associated with microalbuminuria (MA) in subjects with diabetes, investigate the predictive value of MA as a marker of risk for diabetic nephropathy (DN), and define risk factors associated with the development and progression of MA. RESEARCH DESIGN AND METHODS—We conducted a prospective longitudinal study of 23 diabetic subjects with persistent MA and 209 diabetic subjects without MA who attended diabetes clinics at the University of Michigan Medical Center in 1989 and 1990. Both groups were examined at baseline and after 7 years. At baseline, urinary albumin–to–creatinine ratios were studied in random, first morning, and 24-h urine samples. At follow-up, a 12-h overnight urine sample was collected and analyzed for albumin and creatinine. At baseline, MA was defined by at least two separate urine specimens with albumin–to–creatinine ratios between 30 and 299 μg albumin per milligram of creatinine. RESULTS—MA regressed in 56% of subjects with baseline MA without systematic application of corrective measures and developed in 16% of subjects without baseline MA. The predictive value positive of MA as a marker of risk for DN was 43%, and the predictive value negative was 77%. In the combined cohort, the incidence and progression of MA were significantly associated with poor glycemic control and duration of diabetes between 10 and 14 years. CONCLUSIONS—MA may not be as sensitive and specific a predictor of DN as previously suggested. Other markers of risk for DN are needed for optimal clinical management. |
| تدمد: | 1935-5548 0149-5992 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7b45d924c7262a945e09b00c3fff02eTest https://doi.org/10.2337/diacare.24.9.1560Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d7b45d924c7262a945e09b00c3fff02e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19355548 01495992 |
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