المؤلفون: 三宅, 俊太郎, Miyake, Shuntarou

مصطلحات موضوعية: poly(A)+ RNA, DHODH, ATM(Ataxia Telangiectasia Mutated), ミトコンドリア呼吸酵素複合体III, ピリミジン

وصف الملف: application/pdf

الوصول الحر: https://ndlsearch.ndl.go.jp/books/R100000039-I12911942Test

Degree: 博士(生命科学) -- Doctor of Philosophy in Life Sciences -- 京都大学

المؤلفون: Miyake, Shuntarou

المساهمون: 片山, 高嶺, 高田, 穣, 原田, 浩

مصطلحات موضوعية: ピリミジン, poly(A)+ RNA, DHODH, ミトコンドリア呼吸酵素複合体III, ATM(Ataxia Telangiectasia Mutated)

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=jairo_______::3a02d2206ef46820c108b7a1c834c46aTest
http://hdl.handle.net/2433/283872Test

المؤلفون: Hao Wang, Lei Wang, Keyi Jia, Yu Liu, Sha Zhao, Wei Li, Caicun Zhou, Minlin Jiang, Bin Chen, Yayi He

المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 2983-2994 (2021)

مصطلحات موضوعية: Genome instability, PD-L1, programmed death ligand 1, BRCA, breast cancer susceptibility gene, ICI, immune checkpoint inhibitor, medicine.medical_treatment, MUTYH, MutY homolog, cGAS, cyclic GMP–AMP synthase, Review, DNA damage response, Malignant transformation, ORR, objective response rate, PCR, polymerase chain reaction, 0302 clinical medicine, SCNAs, somatic copy number alterations, FDA, United State Food and Drug Administration, Cancer immunotherapy, MGMT, O6-methylguanine methyltransferase, PD-1, RB1, retinoblastoma 1, General Pharmacology, Toxicology and Pharmaceutics, BER, base excision repair, RAD51C, RAD51 homolog C, 0303 health sciences, TME, tumor microenvironment, TP53, tumor protein P53, cGAS–STING, MSI, microsatellite instability, TRIF, Toll-interleukin 1 receptor domain-containing adaptor inducing INF-β, PFS, progression-free survival, STAT, signal transducer and activator of transcription, NEK1, NIMA-related kinase 1, Tumor microenvironment, PALB2, partner and localizer of BRCA2, RSR, replication stress response, 030220 oncology & carcinogenesis, Immunotherapy, PARP, poly-ADP ribose polymerase, JAK, Janus kinase, IHC, immunohistochemistry, Genomic instability, PD-L1, DSBs, double-strand breaks, DNA repair, DNA damage, CHK1, checkpoint kinase 1, IRF1, interferon regulatory factor 1, MLH1, MutL homolog 1, RM1-950, MMR, mismatch repair, STING, stimulator of interferon genes, Biology, MNT, MAX network transcriptional repressor, DDR, DNA damage response, MSH2/6, MutS protein homologue-2/6, OS, overall survival, RPA, replication protein A, 03 medical and health sciences, GSK3β, glycogen synthase kinase 3β, NER, nucleotide excision repair, NSCLC, non-small cell lung cancer, MyD88, myeloid differentiation factor 88, ssDNA, single-stranded DNA, medicine, DAMP, damage-associated molecular patterns, DR, direct repair, 030304 developmental biology, BAP1, BRCA1-associated protein 1, BRAF, v-RAF murine sarcoma viral oncogene homologue B, TLR4, Toll-like receptor 4, Cancer, NGS, next generation sequencing, ATM, ataxia-telangiectasia mutated, NIMA, never-in-mitosis A, medicine.disease, CHEK, cell-cycle checkpoint kinase, PD-1, programmed death 1, MAD1, mitotic arrest deficient-like 1, body regions, IFNγ, interferon gamma, TILs, tumor-infiltrating lymphocytes, TBK1, TANK-binding kinase 1, ATR, ataxia telangiectasia and Rad3 related, Cancer research, NHEJ, nonhomologous end-joining, Therapeutics. Pharmacology, HMGB1, high mobility group box-1, HRR, homologous recombination repair, XRCC4, X-ray repair cross complementing protein 4, TMB, tumor mutational burden

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbe73202674a833d134ec811bcbf7332Test
https://doi.org/10.1016/j.apsb.2021.01.003Test

المؤلفون: Paz Boix-Montesinos, Mar Orzáez, Ana Armiñán, Paula M. Soriano-Teruel, María J. Vicent

المصدر: Advanced Drug Delivery Reviews

مصطلحات موضوعية: ICAM1, Intercellular adhesion molecule–1, PLA, Poly(lactide), GEMM, Genetically modified mouse model, RAG, Rag-deficient, 02 engineering and technology, Metastasis, CCPM, Core-crosslinked block copolymer micelle, TME, Tumor microenvironment, TAM, Tumor-associated macrophages, Breast cancer, NIR, Near-infrared, Th2, Type 2 T helper, NK, Natural killer, AGM, Aminoglutethimide, Medicine, NF1, Neurofibromin 1, BRCA1, Breast cancer type 1 susceptibility protein, SPIO, Superparamagnetic iron oxide nanoparticle, 0303 health sciences, education.field_of_study, ERS1, Estrogen receptor gene, BRCA2, Breast cancer type 2 susceptibility protein, Organoids, CHEK2, Checkpoint kinase 2, Patient-derived xenografts, Nanomedicine, PTBPC, Poly(2‐((tert‐butoxycarbonyl)amino)‐3‐propyl carbonate, DOX, Doxorubicin, 0210 nano-technology, PDOX, Patient-derived organoid-derived xenograft, TNBC, Triple negative breast cancer, NOG, NOD/Shi-scid/γc−/− null, FITC, Fluorescein isothiocyanate, Antineoplastic Agents, 2D, Two-dimensional, MMDOX, Doxorubicin-loaded mixed micelles, Article, NOD-SCID, non-obese diabetic-severe combined immunodeficient, WHO, World Health Organization, FA, Folic acid, PyMT, Polyoma middle tumor-antigen, 03 medical and health sciences, HPMA, Hydroxypropyl methacrylamide, Drug Development, NMU, N-methyl-n-nitrosourea, Humans, SCID, Severe combined immunodeficient, education, WAP, Whey acidic protein, Immune status, MDR1, Multidrug resistance protein 1, PTEN, Phosphatase and tensin homolog, pDNA, Plasmid desoxyribonucleic acid, AuNR, Gold nanorod, medicine.disease, NP, Nanoparticle, VIP, Vasoactive intestinal peptide, Clinical trial, PLGA, poly(lactide-co-glycolide), Nanoparticles, HER2, Epidermal growth factor receptor 2, MMP, Metallopeptidases, Th1, Type 1 T helper, PGA, Poly-L-glutamic acid, Biomarkers, ROS, Reactive oxygen species, IHC, Immunohistochemistry, MMTV, Mouse mammary tumor virus, IO, Iron oxide, IONP, Iron oxide nanoparticle, Pharmaceutical Science, TP53, tumor protein p53, Bioinformatics, ATM, Ataxia-telangiectasia mutated, PALB2, Partner and localizer of BRCA2, Drug Delivery Systems, NSG, NOD scid gamma, uPAR, Urokinase plasminogen activator receptor, PDNA, Plasmid DNA, GSH, Glutathione, LTR, Long terminal repeat, Drug Carriers, EPR, Enhanced permeability and retention, PPTT, Plasmonic photothermal therapy, TPGS, D-α-tocopheryl polyethylene glycol 1000 succinate, DC, Dendritic cells, HIF1α, Hypoxia-inducible factor 1 alpha, MEF, Mouse embryonic fibroblasts, CAF, Cancer-associated fibroblasts, PR, Progesterone receptor, 021001 nanoscience & nanotechnology, Nanomedicines, Animal models, ER, Estrogen receptor, Nude, Athymic nude, DMBA, 7,12-dimethylbenzantracene, PEG, Polyethylene glycol, Female, MUC1, Mucin 1, QbD, Quality by design, 3D, Three-dimensional, PDX, Patient-derived xenograft, Population, Breast Neoplasms, Enhanced permeability and retention effect, Pre-clinical models, CSC, Cancer stem cells, ALOX5, Arachidonate 5-lipoxygenase, iPSC, induced pluripotent stem cells, ECM, Extracellular matrix, ComputingMethodologies_COMPUTERGRAPHICS, 030304 developmental biology, PI3KCA, Phosphatidylinositol 3-kinase, business.industry, SSMM, Sterically-stabilized mixed phospholipid nanomicelle, Cancer, FDA, Food and Drug Administration, PIMs, Porcine pulmonary intravascular macrophages, EGFR, Epithelial growth factor receptor, CDX, Cell-derived xenograft, STK11, Serine/Threonine Kinase 11, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76811ce2af0ea0f7b3342230007c3c01Test
https://doi.org/10.1016/j.addr.2021.03.018Test

المؤلفون: Molly Bristol, Dipon Das, Iain Morgan

المصدر: Viruses; Volume 9; Issue 10; Pages: 268

مصطلحات موضوعية: HPV, human papillomavirus, replication, initiation, life cycle, DNA damage response, TopBP1, E1, E2, ATM (ataxia-telangiectasia mutated), ATR (ataxia telangiectasia and Rad3 related), DNA damage signaling, cervical cancer, head and neck cancer, homologous recombination, MRN (Mre11-Rad50-Nbs1)

جغرافية الموضوع: agris

وصف الملف: application/pdf

العلاقة: https://dx.doi.org/10.3390/v9100268Test

الإتاحة: https://doi.org/10.3390/v9100268Test

المؤلفون: Guangmei Yan, Ying Liu, Jiankai Liang, Ke Li, Xincheng Liu, Wentao Huang, Cheng Hu, Yuan Lin, Jing Cai, Hao Zhang, Liang Peng, Wenbo Zhu, Jianguang Qiu

المصدر: Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 1, Pp 158-168 (2021)

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Oncolytic virus, ISG, interferon-stimulated genes, viruses, Gene Expression, Apoptosis, CCDC6, Coiled-coil-domain containing 6, Mice, 0302 clinical medicine, Interferon pathway, Neoplasms, DNA-PKI, DNA-PK inhibitor, RNA, Small Interfering, Oncolytic Virotherapy, Gene knockdown, M1 virus, HRP, horseradish peroxidase, Transfection, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Endoplasmic Reticulum Stress, ZAP, zinc finger antiviral protein, Oncolytic Viruses, XBP1, X-box binding protein 1, Gene Knockdown Techniques, 030220 oncology & carcinogenesis, RT, room temperature, Oncolytic Virus Therapy, Female, Original article, DAUCs, area under the curve, PVDF, polyvinylidene fluoride, siRNA, Small interfering RNAs, Genetic Vectors, Alphavirus, Biology, lcsh:RC254-282, Virus, 03 medical and health sciences, DNA-PK, DNA-dependent protein kinase, Cell Line, Tumor, Animals, Humans, Genetic Therapy, biology.organism_classification, Xenograft Model Antitumor Assays, IFNs, Interferons, VCP, valosin-containing protein, Cytoskeletal Proteins, Disease Models, Animal, 030104 developmental biology, CCDC6, Cancer cell, Cancer research, ATM, ataxia telangiectasia-mutated

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fdcd32c851e4b9811b639d74f6d69a3Test
https://doi.org/10.1016/j.neo.2020.12.003Test

المؤلفون: Christina Falkeis-Veits, Victoria Neumeyer, Elisabeth Kremmer, Anna Brutau-Abia, Nicole Pfarr, Michael Allgäuer, Raquel Mejías-Luque, Markus Gerhard, Wilko Weichert, Michael Vieth

المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cell. Mol. Gast. Hept. 11, 1071-1094 (2021)
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 1071-1094 (2021)

مصطلحات موضوعية: 0301 basic medicine, Male, ATR, ATM-and Rad3-Related, MSI-high, microsatellite instability-high, Carcinogenesis, RNP, ribonucleoprotein, Apoptosis, medicine.disease_cause, Mice, 0302 clinical medicine, Tumor Cells, Cultured, RNF43, RING finger protein 43, PMSS1, pre-mouse SS1, Wnt Signaling Pathway, Original Research, Aged, 80 and over, Mice, Knockout, Mutation, Stomach, Gastroenterology, Wnt signaling pathway, CHK, checkpoint kinase, Middle Aged, Dna Damage Response (ddr), Gastric Cancer, Helicobacter Pylori, Rnf43, ddc, medicine.anatomical_structure, Editorial, Gastritis, RNF43, GC, gastric cancer, 030211 gastroenterology & hepatology, Female, SNP, single-nucleotide polymorphism, medicine.drug, Adult, MSI, microsatellite unstable, SDS, sodium dodecyl sulfate, DNA damage, Ubiquitin-Protein Ligases, H2AX, H2A histone family member X, WNT, Wingless-related integration site, Biology, DDR, DNA damage response, Helicobacter Infections, 03 medical and health sciences, Stomach Neoplasms, medicine, Animals, Humans, DSB, double-strand break, Viability assay, lcsh:RC799-869, Aged, Cell Proliferation, Cisplatin, Hepatology, Helicobacter pylori, D196, deletion at aspartic acid 196, DNA Damage Response (DDR), ATM, ataxia-telangiectasia mutated, shControl, short hairpin control, biology.organism_classification, Xenograft Model Antitumor Assays, WT, wild-type, CRISPR/Cas9, Clustered related interspaced short palindromic repeats/CRISPR associated 9, Mice, Inbred C57BL, body regions, 030104 developmental biology, Case-Control Studies, shRNF43, short hairpin RING finger protein 43, Cancer research, lcsh:Diseases of the digestive system. Gastroenterology, Biomarkers, DNA Damage

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5395425bca40993817d7158ea7f903c7Test
http://europepmc.org/articles/PMC7898035Test

المؤلفون: Farah Khashab, May Al-Maghrebi, Nora Al-Kandari, Farah Al-Saleh, Fatemah Fadel

المصدر: Saudi Journal of Biological Sciences, Vol 27, Iss 8, Pp 2174-2184 (2020)
Saudi Journal of Biological Sciences

مصطلحات موضوعية: 0106 biological sciences, 0301 basic medicine, O2, molecular oxygen, PERK, pancreatic ER kinase, NADP, nicotinamide adenine dinucleotide phosphate, PCC, protein carbonyl content, DMSO, dimethyl sulfoxide, ST, seminiferous tubule, medicine.disease_cause, 01 natural sciences, ATF, activating transcription factor, eIF2α1, eukaryotic initiation factor 2α1, PVDF, polyvinylidene difluoride, chemistry.chemical_compound, DNA, deoxyribonucleic acid, PCR, polymerase chain reaction, UPR, unfolded protein response, ECL, electrochemiluminescence, TOS, testicular oxidative stress, ASK1, PARP, poly ADP-ribose polymerase, lcsh:QH301-705.5, ANOVA, analysis of variance, ATM, ataxia telangiectasia mutated, NADPH oxidase, RT, reverse transcription, biology, Chemistry, ELISA, enzyme-linked immunosorbent assay, BTB, blood-testis barrier, i.p., intraperitoneal, NOX, NADPH oxidase, JNK, c-Jun N-terminal Kinase, OS, oxidative stress, H2O2, hydrogen peroxide, IAP, inhibitors of apoptosis, p-, phosphorylated, RIPA, radioimmunoprecipitation assay, Germ cell apoptosis, General Agricultural and Biological Sciences, ER stress, kDa, kilodalton, phox, phagocyte oxidase, DNA damage, mRNA, messenger ribonucleic acid, H2AX, histone variant, IRE1, inositol requiring kinase 1, DAPI, diamidino phenylindole, CHOP, CCAAT-enhancer-binding protein homologous protein, TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling, Article, DDR, DNA damage response, Testicular ischemia Reperfusion Injury, ER, endoplasmic reticulum, Superoxide dismutase, Andrology, cDNA, complementary DNA, 03 medical and health sciences, ROS, reactive oxygen species, SOD, superoxide dismutase, GCA, germ cell apoptosis, medicine, IF, immunofluorescence, MDA, malondialdehyde, GRP78, glucose-related protein 78, medicine.disease, O2−, superoxide anion, Chk, checkpoint kinase, 8-OHdG, 8-hydroxy-2′-deoxyguanosine, 030104 developmental biology, lcsh:Biology (General), Oxidative stress, TRAF-2, tumor-necrosis-factor receptor-associated factor 2, SDS-PAGE, sodium dodecyl sulfate polyacrylamide gel electrophoresis, Apocynin, H&E, hematoxylin and eosin, RNA, ribonucleic acid, γ-H2AX, 139 serine-phosphorylated histone variant, Unfolded protein response, biology.protein, ASK1, apoptosis signaling kinase 1, BSA, bovine serum albumin, gDNA, genomic DNA, SD, standard deviation, Reperfusion injury, 010606 plant biology & botany

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25b9b9c3762cf95184a4b635e3a70e69Test
http://www.sciencedirect.com/science/article/pii/S1319562X20301364Test

المؤلفون: Emmanuel Skordalakes, Tomas M. Aramburu, Sarah Plucinsky

المصدر: Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 18, Iss, Pp 1939-1946 (2020)

مصطلحات موضوعية: Telomerase, Ten1, Telomere Length Regulation Protein, TRF1, Telomere Repeat binding Factor 1, DNA damage, lcsh:Biotechnology, Biophysics, POT1, Protection of telomere 1, Review Article, Biology, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Shelterin, 0302 clinical medicine, POT1, Structural Biology, lcsh:TP248.13-248.65, Genetics, TERT, Telomerase Reverse Transcriptase, TRF2, Telomere Repeat binding Factor 2, TIN2, TRF1- and TRF2-Interacting Nuclear Protein 2, RAP1, Repressor/Activator Protein 1, 030304 developmental biology, Ribonucleoprotein, TPP1, CST, CTC1, Stn1 and Ten1, 0303 health sciences, Stn1, Suppressor of Cdc Thirteen, RPA, Replication Protein A, DNA replication, ATR, Ataxia Telangiectasia and Rad3-related Protein, ATM, Ataxia Telangiectasia Mutated protein, USP7, ubiquitin-specific-processing protease 7, Processivity, Computer Science Applications, Telomere, Cell biology, Telomeres, chemistry, TPP1 also known as ACD, Adrenocortical Dysplasia Protein Homolog, 030220 oncology & carcinogenesis, TSPYL5, Testis-specific Y-encoded-like protein 5, TERC, Telomerase RNA, CTC1, Conserved Telomere Capping Protein 1, SMCHD1, Structural Maintenance Of Chromosomes Flexible Hinge Domain Containing 1, DNA, Biotechnology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41dd908869527a7f37cd216b7f0f8687Test
http://europepmc.org/articles/PMC7385035Test

المؤلفون: Daiki Karigane, Kinya Otsu, Shinichiro Okamoto, Nobuhito Goda, Takayuki Morikawa, Hiroshi Kobayashi, Yuriko Sorimachi, Yoshiaki Kubota, Yukako Ootomo, Keiyo Takubo

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, Male, Aging, 53BP1, tumor suppressor p53-binding protein 1, p38MAPK, p38 mitogen-activated kinase, Ataxia Telangiectasia Mutated Proteins, LSK, lineage−Sca-1+c-Kit+ cell, MEXT, Ministry of Education, Culture, Sports, Science and Technology, Biochemistry, Atm, ataxia–telangiectasia mutated, Mitogen-Activated Protein Kinase 14, Mice, GSEA, gene set enrichment analysis, Cellular Senescence, Mice, Knockout, Hematopoietic stem cell, hemic and immune systems, Cell Differentiation, p38αfl/fl, p38αflox/flox, Cell biology, TNFα, tumor necrosis factor α, Haematopoiesis, medicine.anatomical_structure, Phenotype, p38MAPK, Female, Stem cell, TAM, tamoxifen, Research Article, Premature aging, Context (language use), pp38MAPK, phospholyrated-p38MAPK, Biology, PB, peripheral blood, γH2AX, phosphorylated H2A histone family member X, 03 medical and health sciences, ROS, reactive oxygen species, HSC, hematopoietic stem cell, Genetic model, medicine, Animals, MPP, multipotent progenitor cell, Molecular Biology, BMMNCs, bone marrow–derived mononuclear cells, Cell Proliferation, 030102 biochemistry & molecular biology, Cell Biology, LT-HSC, long-term HSC, ataxia–telangiectasia, Hematopoietic Stem Cells, hematopoiesis, BMT, bone marrow transplantation, Transplantation, Mice, Inbred C57BL, 030104 developmental biology, CAG, chicken β-actin promoter with cytomegalovirus enhancer, JSPS, Japan Society for the Promotion of Science, Atmfl/fl, Atmflox/flox, HSPC, hematopoietic stem/progenitor cell, BM, bone marrow, Bone marrow, qPCR, quantitative PCR, Reactive Oxygen Species, transplantation

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3023a653ab26d16f5046991706d862ffTest
http://europepmc.org/articles/PMC8065231Test