المؤلفون: Songsong Wang, Peng Li, Liang Zou, Jianbo Xiao, Feiya Sheng

المصدر: Journal of Advanced Research

مصطلحات موضوعية: 0301 basic medicine, Apolipoprotein E, SREBPs, sterol regulatory element binding proteins, SREBP2, sterol regulatory element-binding protein 2, SHP, small heterodimer partner, chemistry.chemical_compound, 0302 clinical medicine, Non-alcoholic Fatty Liver Disease, LXRα, liver X receptor α, VLDL, very low-density lipoprotein, Multidisciplinary, TG, triglyceride, Bile acid, Chemistry, Fatty liver, FGF15/19, fibroblast growth factor 15/19, Cholesterol, WB, Western blot, ACC, Acetyl-CoA carboxylase, 030220 oncology & carcinogenesis, Lipogenesis, Quercetin, NAFLD, non-alcoholic fatty liver disease, medicine.medical_specialty, Bile acid metabolism, SDS, sodium dodecyl sulfate, TGR5, Takeda G-protein-coupled receptor 5, medicine.drug_class, Hyperoside, LC-MS, the combination of high-performance liquid chromatography and mass spectrometry, Article, Bile Acids and Salts, pACC, phosphorylated ACC, 03 medical and health sciences, Label-free proteomics, FXR, farnesoid X receptor, CYP27A1, sterol 27-hydroxylase, NAFLD, Internal medicine, medicine, Animals, Cholesterol metabolism, Liver X receptor, ComputingMethodologies_COMPUTERGRAPHICS, BAs, bile acids, SREBP1, sterol regulatory element-binding protein 1, Targeted metabolomics, Lipid Metabolism, CYP7A1, cholesterol 7α-hydroxylase, medicine.disease, Rats, TC, total cholesterol, QC, quality control, AMPK, AMP-activated protein kinase, 030104 developmental biology, Endocrinology, PMSF, phenylmethylsulfonyl fluoride, Apo, apolipoprotein, BSH, bile salt hydrolase, Farnesoid X receptor

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a2bd34a875a308c3012404fcb1667ccTest
https://doi.org/10.1016/j.jare.2021.06.001Test

المؤلفون: Fei Luo, Eriks Smagris, Sarah A. Martin, Goncalo Vale, Jeffrey G. McDonald, Justin A. Fletcher, Shawn C. Burgess, Helen H. Hobbs, Jonathan C. Cohen

المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 3, Pp 879-899 (2022)

مصطلحات موضوعية: SDS, sodium dodecyl sulfate, PBS, phosphate-buffered saline, RC799-869, PE, phosphatidylethanolamine, ER, endoplasmic reticulum, PC, phosphatidylcholine, Mice, FLD, fatty liver disease, PCR, polymerase chain reaction, VLDL, very low density lipoprotein, Non-alcoholic Fatty Liver Disease, Animals, mAb, monoclonal antibody, RIPA, radioimmunoprecipitation assay buffer, SER, smooth endoplasmic reticulum, Triglycerides, Original Research, Liver Perfusion, KO, knockout, Hepatology, CE, cholesteryl ester, TG, triglyceride, S2, second supernatant, ACSL5, acyl-CoA synthetase long chain family member 5, Gastroenterology, Membrane Proteins, IP, immunoprecipitation, Diseases of the digestive system. Gastroenterology, LC-MS/MS, liquid chromatography–mass spectrometry, CRISPR/Cas9, clustered regularly interspaced short palindromic repeats and CRISPR-associated protein 9, WT, wild-type, Rats, Fatty Liver, ERGIC, endoplasmic reticulum–Golgi intermediate compartment, RER, rough endoplasmic reticulum, TM6SF2, transmembrane 6 superfamily 2, Apo, apolipoprotein, PI, protease inhibitor cocktail, UTSW, University of Texas Southwestern Medical Center, PFA, paraformaldehyde, VLDL

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c501eab0983bab28ced1482110d3291cTest
http://europepmc.org/articles/PMC8804273Test

المؤلفون: Melanie A. Kimm, Vanessa Franziska Schmidt, Max L.A. Ebert, Lena Pfaff, Anne von Thaden, Moritz Wildgruber

المصدر: JACC: Basic to Translational Science

مصطلحات موضوعية: Vascular smooth muscle, medicine.medical_treatment, HDL, high-density lipoprotein, Cell, neointimal hyperplasia, Bioinformatics, PDGF, platelet-derived growth factor, VSMC, vascular smooth muscle cell, Fibroblast migration, restenosis, Restenosis, LDL, low-density lipoprotein, Angioplasty, medicine, VLDL, very low-density lipoprotein, TGF, transforming growth factor, Neointimal hyperplasia, business.industry, animal model, angioplasty, Stent, Lipid metabolism, medicine.disease, ECM, extracellular matrix, FGF, fibroblast growth factor, CETP, cholesteryl ester transferase protein, LDLr, LDL receptor, medicine.anatomical_structure, Apo, apolipoprotein, State-of-the-Art Review, Cardiology and Cardiovascular Medicine, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88165634a122d3faf899cdcac81ed099Test
https://doi.org/10.1016/j.jacbts.2021.06.006Test

المؤلفون: Tirthadipa Pradhan-Sundd

المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 1199-1201 (2021)

مصطلحات موضوعية: Male, Arteriosclerosis, SREBP, sterol regulatory element-binding protein, CREB3L3, FGF21, fibroblast growth factor 21, Bioinformatics, CREB3L3, cAMP responsive element-binding protein 3 like 3, Mice, Enterohepatic Circulation, Cyclic AMP Response Element-Binding Protein, Insig, insulin-induced gene, Original Research, GFP, green fluorescent protein, Mice, Knockout, Sterol Regulatory Element Binding Proteins, TBA, total bile acid, WD, Western diet, TG, triglyceride, Chemistry, Gastroenterology, Editorial, Hyperlipidemia, LPL, lipoprotein lipase, Female, lipids (amino acids, peptides, and proteins), Sterol Regulatory Element Binding Protein 1, HDL, high-density lipoprotein, Hyperlipidemias, SREBP, ER, endoplasmic reticulum, Competition (economics), Tg, transgenic, FFA, free fatty acid, medicine, Animals, Humans, lcsh:RC799-869, KO, knockout, PPARα, peroxisome proliferator-activated receptor alpha, Hepatology, PLA, proximity ligation assay, S1P, site-1 protease, Lipogenesis, SREBF, sterol regulatory element-binding factor, VLDL, very-low-density lipoprotein, Atherosclerosis, Lipid Metabolism, medicine.disease, Sterol regulatory element-binding protein, Mice, Inbred C57BL, TC, total cholesterol, Gene Expression Regulation, Receptors, LDL, Apo, apolipoprotein, HPLC, high-performance liquid chromatography, HSV, herpes simplex virus, lcsh:Diseases of the digestive system. Gastroenterology, LXR, liver X receptor

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b659cdeaf5713387b2f5a214c940ddfTest
https://doi.org/10.1016/j.jcmgh.2021.01.002Test

المؤلفون: Juro Sakai, Masashi Muramatsu, Toshiya Tanaka, Suguru Nakagawa, Sandra Ryeom, Tatsuhiko Kodama, Yuri Miyamura, Takashi Minami, Hiroyuki Aburatani, Tsuyoshi Osawa

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, Apolipoprotein E, HFD, high-fat diet, Apolipoprotein B, proprotein convertase subtilisin/kexin type (PCSK)9, SREBP, sterol regulatory element-binding protein, Muscle Proteins, Biochemistry, PCSK, proprotein convertase subtilisin/kexin, chemistry.chemical_compound, Mice, LDL, low-density lipoprotein, Nonalcoholic fatty liver disease, nonalcoholic fatty liver disease (NAFLD), apolipoprotein (Apo)E, biology, LDLR, LDL receptor, HRP, horseradish peroxidase, NFAT, DSCR, Down syndrome critical region, VEGF, vascular endothelial growth factor, Cholesterol, Phenotype, regulator of calcineurin (RCAN)1, lipids (amino acids, peptides, and proteins), medicine.symptom, Research Article, medicine.medical_specialty, NFAT, nuclear factor for activated T cell, Down syndrome critical region (DSCR)-1, Hypercholesterolemia, Inflammation, ER, endoplasmic reticulum, 03 medical and health sciences, HEK, human embryonic kidney, Apolipoproteins E, Internal medicine, medicine, low-density lipoprotein (LDL), Animals, nuclear factor for activated T cells (NFAT), oxLDL, oxidative LDL, Molecular Biology, GO, gene ontology, 030102 biochemistry & molecular biology, business.industry, Calcium-Binding Proteins, Cell Biology, medicine.disease, WT, wild-type, Sterol regulatory element-binding protein, 030104 developmental biology, Endocrinology, chemistry, Apo, apolipoprotein, Gene Expression Regulation, LDL receptor, biology.protein, Hepatocytes, NAFLD, nonalcoholic fatty liver disease, business, Gene Deletion

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69e97026d95511588f7efa815e569ed7Test
http://europepmc.org/articles/PMC8142255Test

المؤلفون: Priska Stahel, Gary F. Lewis, Changting Xiao

المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 3, Pp 487-501 (2019)

مصطلحات موضوعية: 0301 basic medicine, SMC, smooth muscle cell, Review, Energy homeostasis, 0302 clinical medicine, Chylomicrons, apo, apolipoprotein, GLP-2, glucagon-like peptide-2, TG, triglyceride, Chemistry, Gastroenterology, eNOS, endothelial nitric oxide synthase, VEGF-C, vascular endothelial growth factor C, MTP, microsomal triglyceride transfer protein, mRNA, messenger RNA, 3. Good health, Cell biology, Intestine, Plin, perilipin, medicine.anatomical_structure, PCTV, prechylomicron transport vesicle, VEGFR, vascular endothelial growth factor receptor, CLD, cytoplasmic lipid droplet, vSNARE, vesicle soluble NSF attachment protein receptor, Lymphatics, 030211 gastroenterology & hepatology, Lymph, Intracellular, SNARE, soluble NSF attachment protein receptor, Enterocyte, CRL, Calcitonin receptor-like receptor, Chylomicron, ER, endoplasmic reticulum, 03 medical and health sciences, medicine, Animals, Humans, Secretion, lcsh:RC799-869, Triglycerides, SDR39U1, short-chain dehydrogenase/reductase family 39U member 1, Lamina propria, NO, nitric oxide, ENS, enteric nervous system, Mucous Membrane, Hepatology, FA, fatty acid, VLDL, very-low-density lipoprotein, Biological Transport, STXBP5, syntaxin-binding protein 5, FABP, fatty acid binding protein, Lipid Metabolism, Dietary Fats, CM, chylomicron, 030104 developmental biology, MG, monoglyceride, GLP-2R, glucagon-like peptide-2 receptor, LCFA, long-chain fatty acid, lcsh:Diseases of the digestive system. Gastroenterology, Lipoprotein, Hormone

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8a8e6ffc9f932c553f64c323df06787Test
http://europepmc.org/articles/PMC6396431Test

المؤلفون: Ebert, Max L A, Schmidt, Vanessa F, Pfaff, Lena, von Thaden, Anne, Kimm, Melanie A, Wildgruber, Moritz

المصدر: JACC Basic to translational science 6(11), 900-917 (2021). doi:10.1016/j.jacbts.2021.06.006

مصطلحات موضوعية: animal model, HDL, high-density lipoprotein, angioplasty, neointimal hyperplasia, PDGF, platelet-derived growth factor, VSMC, vascular smooth muscle cell, ECM, extracellular matrix, FGF, fibroblast growth factor, CETP, cholesteryl ester transferase protein, LDLr, LDL receptor, restenosis, Apo, apolipoprotein, LDL, low-density lipoprotein, VLDL, very low-density lipoprotein, ddc:610, TGF, transforming growth factor

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=od_____10678::dc85333e28de216e8209e7dde8278277Test
https://pub.dzne.de/record/163653Test

المؤلفون: Steven J. Fliesler, Sriganesh Ramachandra Rao, Sithara Raju Ponny, Ned A. Porter, Shailendra B. Patel, Vincent Fong, Babu Nageswararao Kanuri, Keri A. Tallman

المصدر: Journal of Lipid Research, Vol 62, Iss, Pp 100002-(2021)
Journal of Lipid Research

مصطلحات موضوعية: 0301 basic medicine, LC-MS, liquid chromatography-mass spectrometry, dHLan, 24-dihydrolanosterol, 14d-Zyme, 14-dehydrozymostenol, 7-DHC, 7-dehydrocholesterol, 030204 cardiovascular system & hematology, SREBF1/2, sterol regulatory element binding transcription factor half, PPARA, peroxisome proliferator activated receptor alpha, Biochemistry, LKO, liver-specific knockout, LDLR, low density lipoprotein receptor, 0302 clinical medicine, Endocrinology, CYP27A1, Conditional gene knockout, CEACAM1, carcinoembryonic antigen-related cell adhesion molecule 1, Glucose homeostasis, DMAP, 4-dimethylaminopyridine, FDFT1, Farnesyl-diphosphate farnesyl transferase 1, 7-dehydrocholesterol, GEO, Gene Expression Omnibus, SRM, selected reaction monitoring, PPh3, triphenylphosphine, NR1H2/3/4/5, nuclear receptor subfamily 1 group H member 2/3/4/5, 14d-Zym, 14-dehydrozymosterol, ESI, electrospray ionization, Chol, cholesterol, MTTP, microsomal triglyceride transfer protein, dysmorphology, SCARB1, scavenger receptor class B member 1, CYP7A1, cytochrome P450 family 7 subfamily A member 1, FAS, fatty acid synthase, HMGCR, 3-hydroxy-3-methylglutaryl-CoA reductase, Lan, lanosterol, TPM, transcript per million, 7-DHD, 7-dehydrodesmosterol, Knockout mouse, GTT, glucose tolerance test, IACUC, institutional animal care and use committee, Research Article, medicine.medical_specialty, congenital, hereditary, and neonatal diseases and abnormalities, LIPC, hepatic triacylglycerol lipase, CHCl3, trichloromethane, CYP8B1, cytochrome P450 family 8 subfamily B member 1, Et3N, triethylamine, PPARG, peroxisome proliferator activated receptor gamma, ABCB11, ATP binding cassette subfamily B member 11, QD415-436, Biology, Cholesterol 7 alpha-hydroxylase, CD36, cluster of differentiation 36, CYP27A1, cytochrome P450 family 27 subfamily A member 1, ABCG1/5/8, ATP binding cassette subfamily G member 1/5/8, DHCR7, 3β-hydroxysterol-Δ7 reductase, Des, desmosterol, 03 medical and health sciences, Smith-Lemli-Opitz syndrome, Zyme, zymostenol, Internal medicine, DHCR24, 3β-hydroxysterol-Δ24 reductase, medicine, Lath, lathosterol, Liver X receptor, BHT, 2,6-di-tert-butyl-4-methylphenol, 8-DHC, 8-dehydrocholesterol, ITT, insulin tolerance test, UPLC, ultra performance liquid chromatography, ES, embryonic stem, Zym, zymosterol, Cell Biology, medicine.disease, SCARB1, 030104 developmental biology, Smith–Lemli–Opitz syndrome, ABCA1, ATP binding cassette subfamily A member 1, cholesterol synthesis, DMG, dimethylglycine, DHL, 24-dehydrolathosterol, SLOS, Smith-Lemli-Opitz syndrome, APO, apolipoprotein, LXR, liver X receptor, PCSK9, proprotein convertase subtilisin/kexin type 9

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::628669fe15a4d77e5ef7fd0fbdf15f34Test
http://www.sciencedirect.com/science/article/pii/S0022227520437046Test

المؤلفون: C. Cherfils, Laurence Barbot-Trystram, Georges Nouadje, Philippe Giral, Dominique Bonnefont-Rousselot, Randa Bittar, Valérie Fesel-Fouquier, Alain Carrié

المساهمون: Service de Biochimie Métabolique [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Service de Biochimie Endocrinienne et Oncologie [CHU Pitié-Salpêtrière], Laboratoire de Coprologie Fonctionnelle [Pitié-Salpêtrière], Sorbonne Université (SU), Service d’Endocrinologie, Métabolisme et Prévention des Risques Cardio-Vasculaires [CHU Pitié-Salpêtrière], Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] (IHU ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service d'Endocrinologie, Métabolisme et Prévention des Maladies Cardio-vasculaires [CHU Pitié-Salpêtrière], CCSD, Accord Elsevier

المصدر: Practical Laboratory Medicine
Practical Laboratory Medicine, Elsevier, 2020, 18, pp.e00150-. ⟨10.1016/j.plabm.2019.e00150⟩
Practical Laboratory Medicine, 2020, 18, pp.e00150. ⟨10.1016/j.plabm.2019.e00150⟩
Practical Laboratory Medicine, Vol 18, Iss, Pp-(2020)

مصطلحات موضوعية: Apolipoprotein E, 030213 general clinical medicine, HDL, Concordance, [SDV]Life Sciences [q-bio], Clinical Biochemistry, apolipoprotein, IDL, intermediate density lipoprotein, Computational biology, 030204 cardiovascular system & hematology, IDL, Article, LDL, low density lipoprotein, LDL, lcsh:Chemistry, 03 medical and health sciences, Sample volume, VLDL, very low density lipoprotein, 0302 clinical medicine, apo, intermediate density lipoprotein, Medicine, isoelectric focusing, apo, apolipoprotein, Genotyping, Reproducibility, lcsh:R5-920, Radiological and Ultrasound Technology, business.industry, Isoelectric focusing, IEF, Repeatability, HDL, high density lipoprotein, 3. Good health, very low density lipoprotein, [SDV] Life Sciences [q-bio], IEF, isoelectric focusing, Phenotype, lcsh:QD1-999, high density lipoprotein, lipids (amino acids, peptides, and proteins), Semi automatic, business, lcsh:Medicine (General), Isoforms, low density lipoprotein, VLDL

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c6e94ea6828186e728a0eff66201e6bTest
https://hal.archives-ouvertes.fr/hal-03489268Test

المؤلفون: Nele Ferekidis, Inna Khozin-Goldberg, Irina A. Guschina, Alaa Ismail, Daryn Robert Michael, Valerie B. O'Donnell, Dipak Purshottam Ramji, John L. Harwood, Yee-Hung Chan, Sammy Boussiba, Jessica O. Williams, Hayley Gallagher, Victoria J. Tyrrell

المصدر: Biochimica et Biophysica Acta. Molecular Basis of Disease

مصطلحات موضوعية: Lipopolysaccharides, 0301 basic medicine, medicine.medical_treatment, CD36, Interleukin-1beta, NEFA, non esterified fatty acids, Cell, ICAM-1, intercellular adhesion molecule-1, 030204 cardiovascular system & hematology, LY, lucifer yellow, TNF-α, tumour necrosis factor-α, VCAM-1, vascular cell adhesion molecule-1, Monocytes, PDGF, platelet-derived growth factor, Mice, chemistry.chemical_compound, 8,11,14-Eicosatrienoic Acid, 0302 clinical medicine, SR, scavenger receptor, Cell Movement, HASMC, human aortic smooth muscle cells, IFN-γ, interferon-γ, Foam cells, Cells, Cultured, Chemokine CCL2, FCCP, carbonyl cyanide-4-(trifluoromethoxy)phenylhydrazone, Foam cell, Mice, Knockout, HMDM, human monocyte-derived macrophages, AcLDL, acetylated LDL, biology, Chemistry, Intercellular Adhesion Molecule-1, MCP-1, monocyte chemotactic protein-1, Mitochondria, ECM, extracellular matrix, Cell biology, Endothelial stem cell, VSMC, vascular smooth muscle cells, medicine.anatomical_structure, PBMC, peripheral blood mononuclear cells, Smooth muscle cells, Cytokines, LPS, lipopolysaccharide, Molecular Medicine, medicine.symptom, FC, free cholesterol, STAT-1, signal transducer and activator of transcription-1, HUVEC, human umbilical cord endothelial cells, Inflammation, CVD, cardiovascular disease, Article, 03 medical and health sciences, TBHP, tert-butyl hydroperoxide, PUFA, polyunsaturated fatty acid, medicine, Animals, Humans, DGLA, dihomo-γ-linolenic acid, oxLDL, oxidized LDL, Scavenger receptor, Molecular Biology, Cell Proliferation, LA, linoleic acid, ABC, ATP-binding cassette transporter, LXR, liver X receptors, Dihomo-γ-linolenic acid, GLA, gamma-linolenic acid, Macrophages, Growth factor, Atherosclerosis, CE, cholesteryl esters, IL, interleukin, 030104 developmental biology, Gene Expression Regulation, Apo, apolipoprotein, RT-qPCR, real-time quantitative polymerase chain reaction, biology.protein, Gene expression, PGE1, prostaglandin E1

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f07a18194f9f9cb47278ac22ed3a1eeTest