المؤلفون: Stephen J. Thomas, John L. Perez, Stephen P. Lockhart, Subramanian Hariharan, Nicholas Kitchin, Ruth Bailey, Katherine Liau, Eleni Lagkadinou, Özlem Türeci, Ugur Şahin, Xia Xu, Kenneth Koury, Samuel S. Dychter, Claire Lu, Teresa C. Gentile, William C. Gruber

المصدر: Vaccine

مصطلحات موضوعية: safety, Male, NAAT, nucleic acid amplification test, COVID-19 Vaccines, Adolescent, mRNA, messenger ribonucleic acid, efficacy, modRNA, modified ribonucleic acid, APC, antigen presenting cell, Article, US, United States, LNP, lipid nanoparticles, MedDRA, Medical Dictionary for Regulatory Activities, COVID-19, coronavirus disease 2019, vaccine, Neoplasms, Humans, RNA, Messenger, Child, Pandemics, BNT162 Vaccine, General Veterinary, General Immunology and Microbiology, SARS-CoV-2, Public Health, Environmental and Occupational Health, COVID-19, VE, vaccine efficacy, FDA, Food and Drug Administration, IR, incidence rate, CI, confidence interval, HIV, human immunodeficiency virus, UTR, untranslated region, Infectious Diseases, Molecular Medicine, BNT162b2, AE, adverse event, malignancy

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cb5f1adc9988d2825bb0d5a9ad1defcTest
https://doi.org/10.1016/j.vaccine.2021.12.046Test

المؤلفون: Haibo Cheng, Zhigui Wu, Jian Gao, Manru Li, Hongqi Chen, Dongdong Sun, Rui Zhang, Yuxian Shen, Qiang Xu, Xianjia Qi, Yang Sun, Mingxia Zhao, Dijun Chen

المصدر: Acta Pharmaceutica Sinica B, Vol 12, Iss 1, Pp 149-166 (2022)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: Cell type, DSBs, double-strand breaks, Macrophage, Colorectal cancer, CNVs, copy number variations, medicine.medical_treatment, BTLA, B- and T-lymphocyte attenuator, MAPK, mitogen-activated kinase, RM1-950, STING, stimulator of interferon genes, Biology, PTPN11, SHP099, scRNA-seq, single-cell RNA-sequencing, GSEA, gene set enrichment analysis, t-SNE, t-distributed stochastic neighbor embedding, Interferon, scRNA-seq, KRAS, Kirsten rat sarcoma viral oncogene homolog, medicine, General Pharmacology, Toxicology and Pharmaceutics, Type I interferon, PCA, principal component analysis, Tumor microenvironment, CD68, TME, tumor microenvironment, Microsatellite instability, Immunosuppression, MSI, microsatellite instability, Immunotherapy, medicine.disease, MSS, microsatellite stable, digestive system diseases, APC, antigen-presenting cell, CRC, colorectal cancer, Cancer research, Original Article, Therapeutics. Pharmacology, PD-1, programmed cell death 1, medicine.drug, STING

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79268ea53d1ac127b470be7ad862d9e6Test
http://www.sciencedirect.com/science/article/pii/S2211383521002963Test

المؤلفون: Yulia Eygeris, Gaurav Sahay, Mohit Gupta, Jeonghwan Kim

المصدر: Advanced Drug Delivery Reviews

مصطلحات موضوعية: HPLC, High-performance liquid chromatography, TH1, Type 1 T helper cell, DMG-PEG-2000, 1,2-Dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000, IV, Intravenous, Genetic enhancement, APC, Antigen-presenting cell, Pharmaceutical Science, PET-CT, Positron emission tomography- computed tomography, 02 engineering and technology, LNP, Lipid nanoparticle, UTR, Untranslated region, IL, Ionizable lipid, PEG, Poly(ethylene glycol), SARS-CoV-2, Severe acute respiratory syndrome coronavirus-2, ID, Intradermal, ARCA, “Anti-reverse" cap analog, Nanotechnology, IM, Intramuscular, Gene delivery, GMP, Good manufacturing practice, IVT, In vitro transcription, Vaccines, Synthetic, 0303 health sciences, SAXS, Small-angle X-ray scattering, Gene Transfer Techniques, Self-assembly, PBAE, Poly(beta-amino esters), 021001 nanoscience & nanotechnology, DC, Dendritic cell, mRNA, Messenger RNA, Vaccination, DSPC, 1,2-Distearoyl-sn-glycero-3-phosphocholine, HIV, Human immunodeficiency virus, COVID-19, Coronavirus Disease 2019, siRNA, Small interfering RNA, DOTAP, 1,2-Dioleoyl-3-trimethylammonium-propane, RSV, Respiratory syncytial virus, ApoE, Apolipoprotein E, 0210 nano-technology, EUA, Emergency Use Authorization, DOTMA, 1,2-Di-O-octadecenyl-3-trimethylammonium propane, TLR, Toll-like receptor, Immune activation, DODMA, 1,2-Dioleyloxy-3-dimethylaminopropane, COVID-19 Vaccines, Coronavirus disease 2019 (COVID-19), GC, Germinal center, Computational biology, BCR, B-cell receptor, Biology, DLin-MC3-DMA, MC3, (6Z,9Z,28Z,31Z)-Heptatriacont-6,9,28,31-tetraene-19-yl 4-(dimethylamino)butanoate, Article, Self assembled, saRNA, Self-amplifying RNA, 03 medical and health sciences, PEI, Poly(ethylene imine), DOPE, 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine, SAR, Structure-activity relationship, mRNA delivery, ACE2, Angiotensin-converting enzyme 2, DGTS, 1,2-Dipalmitoyl-sn-glycero-3-O-4'-(N,N,N-trimethyl)-homoserine, Animals, Humans, RNA, Messenger, IgA, IgG, Immunoglobulin A, G, 030304 developmental biology, MHC, Major histocompatibility complex, Messenger RNA, PLGA, Poly(lactic-co-glycolic acid), SC, Subcutaneous, COVID-19, LN, Lymph node, RBD, Receptor Binding Domain, Immunization, Drug Design, DOGS, N1,N1'-(8-(dioctadecylamino)-5,8-dioxooctane-1,4-diyl)bis(propane-1,3-diaminium), Lipid nanoparticles, Nanoparticles, pDNA, Plasmid DNA, Cryo-(T)EM, Cryogenic (transmission) electron microscopy

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b0f88a1e945504ba8b4af825e8da083Test
https://doi.org/10.1016/j.addr.2020.12.014Test

المؤلفون: Karen A. Simmons, Li Luo, Erica J. Dashner-Titus, Debra MacKenzie, Laurie G. Hudson, Jodi R. Schilz

المصدر: Toxicology Reports, Vol 8, Iss, Pp 1917-1929 (2021)
Toxicology Reports

مصطلحات موضوعية: Sodium arsenite, Health, Toxicology and Mutagenesis, CD3, Uranyl acetate, GCLM, glutamate-cysteine ligase, APC, antigen presenting cell, Toxicology, NQO1, NAD(P)H quinone dehydrogenase, Arsenic, SOD1, super oxide dismutase 1, chemistry.chemical_compound, RA1190-1270, DEG, differentially expressed gene, Gene expression, T-lymphocytes, ComputingMethodologies_COMPUTERGRAPHICS, AUM, abandoned uranium mine, Th, T-helper, PCA, principal component analysis, Mixture toxicology, biology, MHC, major histone compatibility complex, CD28, Regular Article, Molecular biology, IFNγ, interferon gamma, chemistry, TCR, T-cell receptor, Toxicology. Poisons, biology.protein, Uranium, IL-2, interleukin 2, Co exposure, HMOX1, heme oxygenase 1

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e02ed1fd8c3c4023146cd14f108fc58aTest
https://doi.org/10.1016/j.toxrep.2021.11.019Test

المؤلفون: Martin J. Loessner, Mathias Schmelcher, Noël Stierlin, Léa V. Zinsli

المصدر: Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 315-329 (2021)
Computational and Structural Biotechnology Journal, 19

مصطلحات موضوعية: HAP, Homo-amino-acid polymer, NMR, Nuclear magnetic resonance, EPO, Erythropoietin, ANN, Artificial neural network, ELP, Elastin-like polypeptide, APC, Antigen-presenting cell, Review, SVM, Support vector machine, Ig, Immunoglobulin, Biochemistry, Epitope, chemistry.chemical_compound, 0302 clinical medicine, Structural Biology, BCR, B cell receptor, IL, Interleukin, PAMP, Pathogen-associated molecular pattern, LPS, Lipopolysaccharide, ADA, Anti-drug antibody, 0303 health sciences, Protein therapeutics, TCR, T cell receptor, Immunogenicity, Protein therapeutic, Anti-drug-antibody, T cell epitope, B cell epitope, GLK, Gelatin-like protein, PBMC, Peripheral blood mononuclear cell, RNN, Recurrent artificial neural network, ABR, Antigen-binding region, DC, Dendritic cell, Computer Science Applications, HLA, Human leukocyte antigen, PD, Pharmacodynamics, TAP, Transporter associated with antigen processing, PEG, Polyethylene glycol, 030220 oncology & carcinogenesis, TLR, Toll-like receptor, Biotechnology, PRR, Pattern recognition receptor, ER, Endoplasmatic reticulum, Glycosylation, Reductive methylation, Biophysics, HMM, Hidden Markov model, Mutagenesis (molecular biology technique), CDR, Complementarity determining region, Computational biology, Biology, PAS, Polypeptide composed of proline, alanine, and/or serine, PSA, Sialic acid polymers, 03 medical and health sciences, CRISPR, Clustered regularly interspaced short palindromic repeats, Genetics, PK, Pharmacokinetics, Deimmunization, ComputingMethodologies_COMPUTERGRAPHICS, 030304 developmental biology, MHC, Major histocompatibility complex, Bab, Binding antibody, XTEN, “Xtended” recombinant polypeptide, Nab, Neutralizing antibody, chemistry, PEGylation, TP248.13-248.65

وصف الملف: application/application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bc6eb34d6710e1da9ae4b3df006a799Test
https://doi.org/10.1016/j.csbj.2020.12.024Test

المؤلفون: Wen-Hsiang Chen, Jeroen Pollet, Ulrich Strych

المصدر: Advanced Drug Delivery Reviews

مصطلحات موضوعية: Vaccine delivery, SARS, Severe acute respiratory syndrome, TMPRSS2, Transmembrane protease serine 2, Alum, Aluminum hydroxide, APC, Antigen-presenting cell, Pharmaceutical Science, 02 engineering and technology, medicine.disease_cause, law.invention, Th1, aa, Amino acid, Clinical trials, law, Pandemic, CoV, Coronavirus, Coronavirus, 0303 health sciences, Public information, Clinical Trials as Topic, Vaccines, Synthetic, OWS, Operation Warp Speed, Vaccine production, RBM, Receptor binding motif, 021001 nanoscience & nanotechnology, Recombinant Proteins, HHS, US Department of Health and Human Services, Recombinant DNA, RSV, Respiratory syncytial virus, Health Resources, PTM, Post-translational modification, 0210 nano-technology, ADE, Antibody-dependent enhancement, Coronavirus Infections, 2019-20 coronavirus outbreak, COVID-19 Vaccines, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), RBD, Receptor binding domain, cGMP, Current good manufacturing practices, Neutralizing antibodies, Article, WHO, World Health Organization, Viral vector, 03 medical and health sciences, Drug Development, medicine, Animals, Humans, Adjuvants, NTD, N-terminal domain, Pandemics, 030304 developmental biology, SARS-CoV-2, MERS, Middle East respiratory syndrome, other, COVID-19, Viral Vaccines, S-protein, Spike protein (S1/S2), COVID, Coronavirus disease 2019, Virology, FDA, US Federal Drug Administration, Business, ACE-2, Angiotensin-converting enzyme 2, MNA, Micro-needle array

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc05cf6e45db923a4422845905a5a74fTest
http://europepmc.org/articles/PMC7788321Test

المؤلفون: Justin Vargas, Govind Bhagat, Peter H.R. Green, Xuechen B. Yu

المصدر: Cellular and Molecular Gastroenterology and Hepatology

مصطلحات موضوعية: 0301 basic medicine, Review, RCD, refractory celiac disease, Th1, T-helper 1, Mice, DC, dendritic cell, 0302 clinical medicine, HVEM, herpesvirus entry mediator, IEL, intraepithelial lymphocyte, Lymphocytes, Intestinal Mucosa, skin and connective tissue diseases, Intraepithelial Lymphocytes, Tissue homeostasis, TNF, tumor necrosis factor, GDNF, glial cell line-derived neurotrophic factor, Innate lymphoid cell, Gastroenterology, ILC, innate lymphoid cell, GI, gastrointestinal, Acquired immune system, FoxP3, forkhead box protein 3, AREG, amphiregulin, medicine.anatomical_structure, Tregs, regulatory T cells, 030211 gastroenterology & hepatology, ieILC1s, intraepithelial ILC1s, NCR, natural cytotoxic receptor, medicine.symptom, Refractory Celiac Disease, PCNA, proliferating cell nuclear antigen, LTi, lymphoid tissue-inducer, Inflammation, Biology, Innate Lymphoid Cells, 03 medical and health sciences, Immune system, GFD, gluten-free diet, medicine, Animals, Humans, IFN, interferon, Lin–, lineage marker negative, tTG, tissue transglutaminase, Lamina propria, Innate immune system, EATL, enteropathy-associated T-cell lymphoma, Hepatology, Immunity, Innate, IL, interleukin, body regions, Celiac Disease, Disease Models, Animal, 030104 developmental biology, APC, antigen-presenting cell, TCR, T-cell receptor, CD, celiac disease, Immunology, Intraepithelial lymphocyte, ILCregs, regulatory innate lymphoid cells

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e702a75de5957371ae55d9bcbdb2bcd7Test
https://doi.org/10.1016/j.jcmgh.2020.12.002Test

المؤلفون: Shaghayegh Haghjooy Javanmard, Abbas Alibakhshi, Elmira Mohammadi, Sahar Esfandyari, Leila Beikmohammadi, Samira Bahrami, Mohammad Mehdi Ranjbar, Shahrzad Ahangarzadeh, Fatemeh Mahmoudian, Kiana Shahzamani

المصدر: International Immunopharmacology

مصطلحات موضوعية: Vaccine delivery, SARS-CoV-2, Severe Acute Respiratory Syndrome Coronavirus-2, APC, Antigen-Presenting Cell, S.C., Subcutaneous, MERS, Middle East Respiratory Syndrome, RSV, Respiratory Syncytial Virus, Disease, SAGE, Strategic Advisory Group of Experts on Immunization, Health Services Accessibility, Delivery methods, Immunology and Allergy, Drug Approval, Vaccine design, CDC, Centers for Disease Control and Prevention, PAMP, Pathogen-Associated Molecular Pattern, LNP, Lipid Nanoparticles, Vaccination, LMH, Live Modified Horsepox, Chimpanzee Adenoviral Vector 1, ChAdOx1, Ad, Adenovirus, GMV, Genetically Modified Viruses, TLR, Toll-Like Receptor, EUA, Emergency Use Authorization, ACE2, Angiotensin Converting Enzyme 2, Coalition for Epidemic Preparedness Innovations, medicine.medical_specialty, 2019-20 coronavirus outbreak, COVID-19 Vaccines, Coronavirus disease 2019 (COVID-19), I.M., Intramuscular, Emerging technologies, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), VRP, Virion Replicon Particle, Immunology, ASHP, American Society of Health-System Pharmacists, Article, SDG 3 - Good Health and Well-being, medicine, Humans, Intensive care medicine, LAV, Live-Attenuated Virus, Disease burden, Pharmacology, VLP, Virus-Like Particle, SARS-CoV-2, COVID-19, Coronavirus Disease-19, business.industry, COVID-19, RBD, Receptor Binding Domain, PRR, Pattern Recognition Receptors, MVA, Modified Vaccinia Ankara, VEE, Venezuelan Equine Encephalitis, Nanoparticles, business, Vaccine, WCA, Whole-Cell Antigen

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97c9be9438e08539da23317f11ef7827Test
http://www.scopus.com/inward/record.url?scp=85113388882&partnerID=8YFLogxKTest

المؤلفون: Xiaohui Pan, Bo Yang, Hongjie Guo, Shuyuan Cheng, Xi Chen, Ling Ding, Qiaojun He, Wenxin Zhang

المصدر: Acta Pharmaceutica Sinica B, Vol 10, Iss 5, Pp 723-733 (2020)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: TIM-3, T cell immunoglobulin and mucin domain 3, H3K27me3, tri-methylation of lysine 27 on histone H3, MDSCs, myeloid-derived suppressor cells, medicine.medical_treatment, Review, TAA, tumor-associated antigen, DC, dendritic cell, 0302 clinical medicine, EZH2, enhancer of zeste homolog 2, LAG-3, lymphocyte activation gene-3, CTLA-4, cytotoxic T lymphocyte antigen 4, Medicine, BETi, bromodomain and extra-terminal motif inhibitors, General Pharmacology, Toxicology and Pharmaceutics, FOXP3, forkhead box P3, HDACi, histone deacetylase inhibitor, Cancer, 0303 health sciences, ACE1, angiotensin converting enzyme, CLL, chronic lymphocytic leukemia, biology, IDO, indoleamine 2,3-dioxygenase, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Tregs, regulatory T cells, PD-L1/PD-1 blockade, CCL22 (MDC), macrophage-derived chemokine, Immunotherapy, TET2, ten-eleven translocation 2, CTLs, cytotoxic T lymphocytes, FDA, U. S. Food and Drug Administration, PD-L1, programmed cell death ligand 1, T cell, CTA, cancer testis antigen, Immune cycle, TIL, tumor infiltrating lymphocytes, Epigenetic regulation, OS, overall survival, 03 medical and health sciences, Immune system, Antigen, PD-L1, TH-1, T helper type 1, DNMT1, DNA methyltransferase 1, MHC, major histocompatibility complex, CX3CL1, C-X3-C motif chemokine ligand 1, IFN-γ, interferon-gamma, 030304 developmental biology, business.industry, lcsh:RM1-950, biochemical phenomena, metabolism, and nutrition, medicine.disease, CXCL, CXC chemokine ligand, Blockade, lcsh:Therapeutics. Pharmacology, APC, antigen-presenting cell, UHRF1, ubiquitin-like PHD and RING finger domain-containing 1, 5-AzaC, 5-azacitidine, ACP1, human red cell acid phosphatase, biology.protein, Cancer research, bacteria, DNMTi, DNA methyltransferase inhibitors, PD-1, programmed cell death 1, business, PRC2, polycomb repressive complex 2

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1ca7b0479f6fea7a89a3e1eb06905c5Test
https://doi.org/10.1016/j.apsb.2019.09.006Test

المؤلفون: Christine P. Petersen, Kevin A. Bockerstett, Richard J. DiPaolo, Christine N. Noto, Ryan M. Teague, Lindsey M. Kuehm, Eric L. Ford, Jason C. Mills, James R. Goldenring, Chun Fung Wong

المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 3, Pp 561-579 (2020)

مصطلحات موضوعية: 0301 basic medicine, CD4-Positive T-Lymphocytes, Male, Pathology, Chronic gastritis, Severity of Illness Index, Immune Regulation, Mice, 0302 clinical medicine, Metaplasia, Parietal cell, Original Research, Mice, Knockout, SPEM, spasmolytic polypeptide-expressing metaplasia, Stomach, Gastroenterology, CD44v9, CD44 variant 9, Recombinant Proteins, medicine.anatomical_structure, EpCAM, epithelial cell adhesion molecule, Gastritis, 030211 gastroenterology & hepatology, Lymphocyte, Female, medicine.symptom, rIL27, recombinant interleukin 27, Transcription, GS-II, griffonia simplicifolia, medicine.medical_specialty, Autoimmune Gastritis, PBS, phosphate-buffered saline, Th, helper T cell, Autoimmune Diseases, Minor Histocompatibility Antigens, 03 medical and health sciences, cDNA, complementary DNA, Immune system, EBI, Epstein-Barr Virus-Induced Gene, medicine, Gastric mucosa, MHC, major histocompatibility complex, Animals, Humans, IFN, interferon, lcsh:RC799-869, Receptors, Cytokine, Mouse Model, Hepatology, business.industry, Interleukins, scRNA, single-cell RNA, PDX1, pancreatic and duodenal homeobox 1, medicine.disease, qRT-PCR, quantitative reverse-transcription polymerase chain reaction, HDT, high-dose tamoxifen, IL, interleukin, Treg, regulatory T cells, Disease Models, Animal, 030104 developmental biology, APC, antigen-presenting cell, IF, immunofluorescent, Gastric Mucosa, Chronic Disease, lcsh:Diseases of the digestive system. Gastroenterology, GIF, gastric intrinsic factor, Atrophy, business, Precancerous Conditions

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5944bc3c0b7785e1a2d843431f7bb28fTest
http://europepmc.org/articles/PMC7399182Test