المؤلفون: Mariano Vázquez, Alfonso Santiago, Alfonso Bueno-Orovio, Blanca Rodriguez, Francesca Margara, Zhinuo J. Wang, Francesc Levrero-Florencio

المصدر: Progress in Biophysics and Molecular Biology
OpenAIRE
PubMed Central
UnpayWall
ORCID
Microsoft Academic Graph
Sygma

مصطلحات موضوعية: Force generation, Inotrope, Drug-Related Side Effects and Adverse Reactions, Computer science, CaT, calcium transient, In silico, Heart Ventricles, 030303 biophysics, Biophysics, Action Potentials, Risk Assessment, Article, EAD, early afterdepolarisation, 03 medical and health sciences, Active contraction, Calcium dynamics, APD, action potential duration, Humans, Myocytes, Cardiac, Human ventricular action potential, Drug safety, Molecular Biology, 0303 health sciences, Models, Cardiovascular, Arrhythmias, Cardiac, Computer simulation, Myocardial Contraction, Pharmacological action, Biomechanical Phenomena, Electrophysiological Phenomena, Coupling (electronics), Electrophysiology, Computational modelling, Human cardiac contraction, In-silico drug trials, Calcium, AP, action potential, Neuroscience

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74f5102b0bbc233b1af7bc652ae25f38Test

المؤلفون: Oleg Bogachev, Sara A. Rafferty, Yingjie Liu, Rui Hua, Hailey J. Jansen, Megan D. McRae, Motahareh Moghtadaei, Robert A. Rose, Adam W. Kirkby, Jaspreet Kaur, Gibanananda Ray, Emmanuel E. Egom, Martin Mackasey

المصدر: JACC: Basic to Translational Science, Vol 3, Iss 6, Pp 824-843 (2018)
JACC: Basic to Translational Science

مصطلحات موضوعية: 0301 basic medicine, lcsh:Diseases of the circulatory (Cardiovascular) system, sinoatrial node, NP, natriuretic peptide, 030204 cardiovascular system & hematology, PRECLINICAL RESEARCH, IV, current voltage relationship, 0302 clinical medicine, Fibrosis, Natriuretic peptide, Myocyte, Receptor, SAN, sinoatrial node, HR, heart rate, 3. Good health, medicine.anatomical_structure, ICa,T, T-type calcium current, Cardiology and Cardiovascular Medicine, Agonist, medicine.medical_specialty, hypertension, medicine.drug_class, V1/2(act), voltage for 50% channel activation, 03 medical and health sciences, Internal medicine, medicine, INCX, sodium–calcium exchanger current, Ang II, angiotensin II, natriuretic peptide, business.industry, Sinoatrial node, SBP, systolic blood pressure, fibrosis, Gmax, maximum conductance, ICa,L, L-type calcium current, medicine.disease, Angiotensin II, NPR-C, natriuretic peptide receptor C, 030104 developmental biology, Endocrinology, lcsh:RC666-701, NPR, natriuretic peptide receptor, If, hyperpolarization-activated current, ion currents, AP, action potential, CV, conduction velocity, DD, diastolic depolarization, business, cSNRT, corrected sinoatrial node recovery time, Hormone

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68cdb596fe58db99fec50a0640c1d6edTest
http://www.sciencedirect.com/science/article/pii/S2452302X18302237Test

المؤلفون: Ivan Silbern, Henning Urlaub, Reinhard Jahn, Kuan-Ting Pan, Stefan Bonn, Maksims Fiosins, Silvio O. Rizzoli, Eugenio F. Fornasiero

المصدر: Molecular & Cellular Proteomics : MCP
Molecular and Cellular Proteomics
Molecular & cellular proteomics 20, 100061-(2021). doi:10.1016/j.mcpro.2021.100061

مصطلحات موضوعية: Botulinum Toxins, CK1, casein kinase 1, SNAP-25, synaptosomal-associated protein, 25kDa, Syntaxin 1, synaptobrevin, CLK, SRPK1 and Clk/Sty protein kinase, Biochemistry, CREB1, CAMP-responsive element binding protein 1, PAK, p21-activated kinase, Analytical Chemistry, SV, synaptic vesicle, AAV, adeno-associated virus, Receptor, Cannabinoid, CB1, TEAB, triethylammonium bicarbonate buffer, Clostridium botulinum, Syntaxin, metabolism [Calcium], metabolism [Syntaxin 1], NMDAR, N-methyl-d-aspartate receptor, metabolism [Phosphoproteins], Neurons, 0303 health sciences, AGC, automatic gain control, 030302 biochemistry & molecular biology, pharmacology [Neurotoxins], STE, “sterile” serine/threonine protein kinases, Endocytosis, Cell biology, DAPK, death-associated protein kinase, metabolism [Neurons], SNARE, RT, room temperature, GRK, G-protein-coupled receptor kinase, GluDH, glutamate dehydrogenase, Synaptic vesicle, Exocytosis, 03 medical and health sciences, PKC, protein kinase C, Humans, Rats, Wistar, Molecular Biology, metabolism [Synaptic Vesicles], metabolism [Glutamic Acid], CAA, chloroacetamide, cytology [Hippocampus], CaMKII, calcium-calmodulin kinase 2, MAPK, mitogen-activated protein kinase, HeLa Cells, ITR, inverted terminal repeat (sequence), Proteome, SNARE, N-ethylmaleimide-sensitive factor-attachment protein receptors, BoNT, botulinum neurotoxin, Hippocampus, R-SNARE Proteins, synapse, botulinum neurotoxins, Protein phosphorylation, POI, protein of interest, Phosphorylation, bRP, basic reversed-phase chromatography, CDK, cyclin-dependent kinase, FA, formic acid, TFE, trifluoroethanol, Voltage-dependent calcium channel, Chemistry, Depolarization, PP1, protein phosphatase 1, metabolism [Receptor, Cannabinoid, CB1], AMPAR, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor, Synaptic Vesicles, exocytosis, syntaxin, TCEP, tris(2-carboxyethyl)phosphine, Neurotoxins, PNGase F, peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase, Glutamic Acid, AMPA receptor, Neurotransmission, phosphomimetic studies, pharmacology [Botulinum Toxins], GSK3, glycogen synthase kinase 3, Animals, AGC, protein kinase A, G, C kinase group, ddc:610, metabolism [Synaptosomes], 030304 developmental biology, GO, gene ontology, metabolism [R-SNARE Proteins], Research, cannabinoid receptor, ACN, acetonitrile, Phosphoproteins, CK2, casein kinase 2, RAS, rat sarcoma gene, Calcium, AP, action potential, CMGC, CDK, MAP, GSK, CDKL kinase group, GABA, γ-aminobutyric acid, Synaptosomes

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81d93635b9e859a1023882c0903a6342Test
https://pubmed.ncbi.nlm.nih.gov/33582301Test

المؤلفون: Stephen D. Meriney, Manuel Covarrubias, Gloria Ortiz, Evan W. Miller, Scott P. Ginebaugh, Kristine S. Ojala, Man Wu

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, Male, NMJ, neuromuscular junction, ROI, region of interest, Action Potentials, Gene Expression, voltage-gated calcium (Cav) channel, Biochemistry, Cav, voltage-gated calcium, Tissue Culture Techniques, Mice, Calcium Channels, N-Type, LEMS, Lambert–Eaton myasthenic syndrome, mEPP, miniature endplate potential, neurological disease, Lambert–Eaton myasthenic syndrome (LEMS), neuromuscular junction (NMJ), Voltage-dependent calcium channel, Chemistry, Transmitter, voltage-gated potassium (Kv) channel, medicine.anatomical_structure, Neuromuscular Agents, Shaw Potassium Channels, FWHM, full width at half maximum, Female, Amifampridine, Lambert-Eaton myasthenic syndrome, Research Article, Agonist, BeRST, Berkeley red-based sensor of transmembrane potential, Calcium Channels, L-Type, medicine.drug_class, Neuromuscular Junction, Presynaptic Terminals, chemistry.chemical_element, Calcium, Neuromuscular junction, 03 medical and health sciences, medicine, Potassium Channel Blockers, Animals, Molecular Biology, QC, quantal content, 030102 biochemistry & molecular biology, Dose-Response Relationship, Drug, Rana pipiens, 3,4-DAP, 3,4-diaminopyridine, Antagonist, Cell Biology, medicine.disease, action potential (AP), Acetylcholine, Electrophysiology, 030104 developmental biology, neurotransmitter release, Biophysics, EPP, endplate potential, AP, action potential, Kv, voltage-gated potassium, Microelectrodes, BTX, alpha-bungarotoxin

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccbc3cf8e9a87415c7993f465b092f47Test
https://pubmed.ncbi.nlm.nih.gov/33465376Test

المؤلفون: Umesh Vivekananda, M. Cano-Jaimez, P.R.F. Mendonca, Erica Tagliatti, Kirill E. Volynski, Dimitri M. Kullmann, E. Nicholson

المصدر: Journal of Neuroscience Methods

مصطلحات موضوعية: 0301 basic medicine, Genetically modified mouse, DIV, days in vitro, Cell Culture Techniques, Action Potentials, Neurotransmission, Hippocampal formation, Biology, DMSO, dimethyl sulfoxide, pv, average probability of vesicular release, SEM, standard error of the mean, Hippocampus, Synaptic Transmission, Cryopreservation, Article, SV, synaptic vesicle, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, PBS, phosphate buffered saline, Animals, DIC, differential interference contrast, Neurotransmitter, Primary neuronal cultures, Hippocampi, Cells, Cultured, Long-term storage, Neurons, General Neuroscience, mEPCS, miniature excitatory post-synaptic currents, Action potential, PLL, poly-L-lysine, RRP, readily-releasable pool, Embryonic stem cell, Genetically modified organism, AP, Action Potential, Mice, Inbred C57BL, 030104 developmental biology, nervous system, chemistry, FBS, foetal bovine serum, Cryopreserved Tissue, BSA, bovine serum albumin, Neuroscience, 030217 neurology & neurosurgery, DAPI, 4′,6-diamidino-2-phenylindole

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c392d58d460c681b1c6b32640440e32Test
http://europepmc.org/articles/PMC7026713Test

المؤلفون: Jin Zhai, Mary Jo Wildey, Elisa Passini, John Imredy, Frederick Sannajust, Kevin Fitzgerald, Anne Chain, Sebastian Polak, Christopher P. Regan, Pierre Morissette, Patrick Fanelli, Jeffrey Travis, Blanca Rodriguez

المصدر: Toxicology and Applied Pharmacology

مصطلحات موضوعية: 0301 basic medicine, ICH, The International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use, TN, True Negative, PPV, Positive Predictive Value, Pharmacology, TdP, Torsade de Pointes, Toxicology, Membrane Potentials, 0302 clinical medicine, HTS, High Throughput Screening, QTcVdW, Van de Water's Heart Rate QT-corrected Interval, In Silico modeling, Medicine, Translational PKPD modeling, NCEs, New Chemical Entities, CTD90, Ca2+-Transient Duration at 90% repolarization, education.field_of_study, Anesthetized Cardiovascular Guinea Pig, HR, Heart Rate, PNV, Predictive Negative Value, Safety pharmacology, ECG, Electrocardiogram, FIH, First in Human, IKr, rapidly-activating delayed rectifier potassium current, AP, Action Potential, QTc, Heart Rate corrected QT Interval, PX, PatchXpress®, 030220 oncology & carcinogenesis, Electrophysiologic Techniques, Cardiac, FP, False Positive, LVP, Left Ventricular Pressure, Anti-Arrhythmia Agents, In silico, Population, Guinea Pigs, QT interval, Models, Biological, Article, Ventricular action potential, Cell Line, CVGP, Cardiovascular Anesthetized Guinea Pig, GP, Guinea Pig, 03 medical and health sciences, hERG, Human Ether-a-go-go Related Gene, Pharmacokinetics, In vivo, Animals, Humans, Computer Simulation, education, QT corrected interval, BP, Blood Pressure, business.industry, M5P, M5 trees automated pruning model, tPKPD, thranslational pharmacokinetic/pharmacodynamic, FLIPR, Fluorescent Imaging Plate Reader, Arrhythmias, Cardiac, ORd, O'Hara Rudy model, Electrophysiological Phenomena, 030104 developmental biology, HEK293 Cells, Models, Chemical, Pharmacodynamics, Torsade de Pointes, EMw, Electromechanical window, FN, False Negative, TP, True Positive, Calcium, Calcium Channels, LOO, Leave-One-Out, business, APD90, Action Potential Duration at 90% repolarization

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::291b9744f97d46ac0f6fd500ad2e1c0fTest
http://europepmc.org/articles/PMC7322544Test

المؤلفون: Kevin J. Munro, Christopher J. Plack, Garreth Prendergast, Rebecca E. Millman, Hannah Guest

المصدر: Guest, H, Munro, K, Prendergast, G, Millman, R & Plack, C 2018, ' Impaired speech perception in noise with a normal audiogram: No evidence for cochlear synaptopathy and no relation to lifetime noise exposure ', Hearing Research, vol. 364, pp. 142-151 . https://doi.org/10.1016/j.heares.2018.03.008Test
Hearing Research

مصطلحات موضوعية: Male, Cochlear synaptopathy, AN, auditory nerve, Speech in noise, Audiology, Cognition, TTS, temporary threshold shift, 0302 clinical medicine, EHF, extended high frequency, Hidden hearing loss, NESI, Noise Exposure Structured Interview, 10. No inequality, 030223 otorhinolaryngology, SPiN, speech perception in noise, Auditory processing disorder, Auditory brainstem response, Audiogram, SNR, signal-to-noise ratio, Sensory Systems, Cochlea, medicine.anatomical_structure, SR, spontaneous rate, Speech Perception, Audiometry, Pure-Tone, Educational Status, Female, Synaptopathy, CRM, Coordinate Response Measure, Hair cell, Obscure auditory dysfunction, Perceptual Masking, Adult, Envelope-following response, medicine.medical_specialty, Speech perception, Adolescent, Stimulus (physiology), SEM, standard error of the mean, Article, Young Adult, 03 medical and health sciences, Evoked Potentials, Auditory, Brain Stem, otorhinolaryngologic diseases, medicine, Humans, business.industry, EFR, envelope-following response, SP, summating potential, Auditory Threshold, ABR, auditory brainstem response, medicine.disease, Electrophysiology, Acoustic Stimulation, Hearing Loss, Noise-Induced, Case-Control Studies, AP, action potential, sense organs, Audiometry, Speech, Noise, business, 030217 neurology & neurosurgery

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::354a66e3557e1227b9b615e1d33dfb30Test
https://doi.org/10.1016/j.heares.2018.03.008Test

المؤلفون: Raffaele, Coppini, Cecilia, Ferrantini, Josè Manuel, Pioner, Lorenzo, Santini, Zhinuo J, Wang, Chiara, Palandri, Marina, Scardigli, Giulia, Vitale, Leonardo, Sacconi, Pierluigi, Stefàno, Laura, Flink, Katherine, Riedy, Francesco Saverio, Pavone, Elisabetta, Cerbai, Corrado, Poggesi, Alessandro, Mugelli, Alfonso, Bueno-Orovio, Iacopo, Olivotto, Mark V, Sherrid

المصدر: JACC: Basic to Translational Science

مصطلحات موضوعية: QT interval, safety, HCM, hypertrophic cardiomyopathy, pCa, Ca activation level, SR, sarcoplasmic reticulum, hERG, human ether-à-go-go-related gene, hypertrophic cardiomyopathy, RyR, ryanodine receptor, EAD, early afterdepolarization, PRECLINICAL RESEARCH, ECG, electrocardiography, ICa-L, L-type Ca current, NCX, Na+/Ca2+ exchanger, IK, delayed-rectifier K current, LVOT, left ventricular outflow tract, diastolic dysfunction, AP, action potential, DAD, delayed afterdepolarization, arrhythmias, INaL, late Na current, action potentials

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::db31ed630cd054e89aee45d7cbbdd683Test
https://pubmed.ncbi.nlm.nih.gov/31998849Test

المؤلفون: Hannah, Guest, Kevin J, Munro, Garreth, Prendergast, Christopher J, Plack

المصدر: Hearing Research

مصطلحات موضوعية: Adult, Envelope-following response, Adolescent, Cochlear Diseases, Cochlear synaptopathy, Otoacoustic Emissions, Spontaneous, AN, auditory nerve, Article, Young Adult, MEMR, middle-ear-muscle reflex, Auditory nerve, Hidden hearing loss, otorhinolaryngologic diseases, Evoked Potentials, Auditory, Brain Stem, Animals, Humans, Cochlear Nerve, ICC, intraclass correlation coefficient, Hair Cells, Auditory, Inner, CF, characteristic frequency, EFR, envelope-following response, Middle-ear-muscle reflex, Reproducibility of Results, SP, summating potential, Auditory Threshold, Auditory brainstem response, ABR, auditory brainstem response, SNR, signal-to-noise ratio, RMS, root mean square, Cochlea, Hearing Loss, Noise-Induced, Synapses, SR, spontaneous rate, Audiometry, Pure-Tone, Female, AP, action potential, SD, standard deviation

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::7e6fb57f2e0001fe1904d2e98e05ac42Test
https://pubmed.ncbi.nlm.nih.gov/30765219Test

المؤلفون: Long-Sheng Song, Francesco S. Pavone, Luca Mazzoni, Chiara Tesi, Josè Manuel Pioner, Claudia Crocini, Leonardo Sacconi, Jil C. Tardiff, Elisabetta Cerbai, Beatrice Scellini, Ping Yan, Leslie M. Loew, Erica Lazzeri, Cecilia Ferrantini, Francesco Vanzi, Raffaele Coppini, Ang Guo, Corrado Poggesi, Marina Scardigli

المصدر: Journal of Molecular and Cellular Cardiology 91 (2016): 42–51. doi:10.1016/j.yjmcc.2015.12.013
info:cnr-pdr/source/autori:Crocini, C.; Ferrantini, C.; Scardigli, M.; Coppini, R.; Mazzoni, L.; Lazzeri, E.; Pioner, J. M.; Scellini, B.; Guo, A.; Song, L. S.; Yan, P.; Loew, L. M.; Tardiff, J.; Tesi, C.; Vanzi, F.; Cerbai, E.; Pavone, F. S.; Sacconi, L.; Poggesi, C./titolo:Novel insights on the relationship between T-tubular defects and contractile dysfunction in a mouse model of hypertrophic cardiomyopathy/doi:10.1016%2Fj.yjmcc.2015.12.013/rivista:Journal of Molecular and Cellular Cardiology/anno:2016/pagina_da:42/pagina_a:51/intervallo_pagine:42–51/volume:91
Journal of Molecular and Cellular Cardiology

مصطلحات موضوعية: AP −, Failing T-tubules, 0301 basic medicine, Myofilament, Action Potentials, Gene Expression, 030204 cardiovascular system & hematology, Imaging, T-tubule, Mice, Sarcolemma, 0302 clinical medicine, Myofibrils, TATS, Transverse-axial tubular system, Myocyte, Myocytes, Cardiac, TTP, Time-to-peak, EXCITATION-CONTRACTION COUPLING, IMAGING, NON-LINEAR MICROSCOPY, HYPERTROPHIC CARDIOMYOPATHY, T-TUBULE, Excitation Contraction Coupling, AP, Action potential, HCM, Hypertrophic cardiomyopathy, Mice, Knockout, Microscopy, Confocal, Chemistry, Optical Imaging, Hypertrophic cardiomyopathy, Actin Cytoskeleton, medicine.anatomical_structure, AP +, Electrically coupled T-tubules, Non-linear microscopy, T-tubules, Original Article, Cardiology and Cardiovascular Medicine, RAMP, Random access multi-photon, medicine.medical_specialty, HF, Heart failure, Excitation–contraction coupling, 03 medical and health sciences, Troponin T, AOD, Acousto-optic deflector, Internal medicine, medicine, Animals, Humans, Calcium Signaling, Molecular Biology, CaT50, Time of 50% Ca2 + decay, Ion Transport, TT, T-tubule, S/N, Signal-to-noise ratio, Cardiomyopathy, Hypertrophic, Actin cytoskeleton, medicine.disease, Myocardial Contraction, Excitation-contraction coupling, Disease Models, Animal, 030104 developmental biology, Endocrinology, SS, Surface sarcolemma, Mutation, Calcium, cTnT, Cardiac troponin T, E–C, Excitation–contraction, Myofibril, VSD, Voltage sensitive dye, Homeostasis

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0622cba30ea6e03df3a8690c8d7c751eTest
https://doi.org/10.1016/j.yjmcc.2015.12.013Test