المؤلفون: Jesus, Nuno Rocha de

مصطلحات موضوعية: Sirolimus, Metformina, Leucemia linfoblástica aguda, mTOR (mammalian target of rampamycin), AMPK (AMP-activated protein kinase), Metformin, Acute lymphoblastic leukemia

الإتاحة: http://hdl.handle.net/10316/97837Test

المؤلفون: Qilong Wang, Yanze Yang, Mei Du, Jinna Wei, Xianxian Zheng, Zhang Han, Erwei Liu, Xiumei Gao, Yuefei Wang, Patrick Kwabena Oduro

المصدر: Acta Pharmaceutica Sinica B, Vol 12, Iss 1, Pp 50-75 (2022)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: HFD, high-fat diet, Cys, cysteine, cGAS, cyclic GMP–AMP synthase, Review, Poly: I.C, polyinosinic-polycytidylic acid, SAVI, STING-associated vasculopathy with onset in infancy, Bioinformatics, PPI, protein–protein interface, TRAF6, tumor necrosis factor receptor-associated factor 6, TREX1, three prime repair exonuclease 1, STIM1, stromal interaction molecule 1, 0302 clinical medicine, AA, amino acids, GTP, guanosine triphosphate, MLKL, mixed lineage kinase domain-like protein, ICAM-1, intracellular adhesion molecule 1, Medicine, PDE3B/4, phosphodiesterase-3B/4, General Pharmacology, Toxicology and Pharmaceutics, IKK, IκB kinase, NF-κB, nuclear factor-kappa B, cGAMP, 2′,3′-cyclic GMP–AMP, NLRP3, NOD-, LRR- and pyrin domain-containing protein 3, 0303 health sciences, dsDNA, double-stranded DNA, TFAM, mitochondrial transcription factor A, Fatty liver, Damage-associated molecular patterns, IFNIC, interferon-inducible cells, CTD, C-terminal domain, Mitochondria, Crosstalk (biology), Cardiovascular diseases, SNPs, single nucleotide polymorphisms, 030220 oncology & carcinogenesis, Stimulator of interferon genes, AAD, aortic aneurysm and dissection, MI, myocardial infarction, IFNAR, interferon receptors, ER stress, CVDs, cardiovascular diseases, NASH, nonalcoholic steatohepatitis, Intracellular, CDG, c-di-GMP, NTase, nucleotidyltransferase, ATP, adenosine triphosphate, Ser, serine, mTOR, mammalian target of rapamycin, RM1-950, STING, stimulator of interferon genes, hSTING, human stimulator of interferon genes, AKT, protein kinase B, CDNs, cyclic dinucleotides, TLR, Toll-like receptors, ER, endoplasmic reticulum, 03 medical and health sciences, LBD, ligand-binding pocket, ROS, reactive oxygen species, YAP1, Yes-associated protein 1, IFN, interferon, ISGs, IRF-3-dependent interferon-stimulated genes, DAMPs, danger-associated molecular patterns, IFN-I, type 1 interferon, 030304 developmental biology, Inflammation, Ang II, angiotensin II, TNFα, tumor necrosis factor-alpha, business.industry, IRF3, interferon regulatory factor 3, CTT, C-terminal tail, Autophagy, TAK1, transforming growth factor β-activated kinase 1, Metabolic diseases, medicine.disease, HAQ, R71H-G230A-R293Q, IL, interleukin, mtDNA, mitochondrial DNA, AMPK, AMP-activated protein kinase, Sting, Apoptosis, TBK1, TANK-binding kinase 1, CBD, C-binding domain, LPS, lipopolysaccharides, NO2-FA, nitro-fatty acids, PKA, protein kinase A, NAFLD, nonalcoholic fatty liver disease, Therapeutics. Pharmacology, DsbA-L, disulfide-bond A oxidoreductase-like protein, business, Homeostasis, MST1, mammalian Ste20-like kinases 1, TM, transmembrane, STING, cGAS

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eaf60046ceb32698b7a7ea7c3674b44Test
http://www.sciencedirect.com/science/article/pii/S2211383521001775Test

المؤلفون: Songsong Wang, Peng Li, Liang Zou, Jianbo Xiao, Feiya Sheng

المصدر: Journal of Advanced Research

مصطلحات موضوعية: 0301 basic medicine, Apolipoprotein E, SREBPs, sterol regulatory element binding proteins, SREBP2, sterol regulatory element-binding protein 2, SHP, small heterodimer partner, chemistry.chemical_compound, 0302 clinical medicine, Non-alcoholic Fatty Liver Disease, LXRα, liver X receptor α, VLDL, very low-density lipoprotein, Multidisciplinary, TG, triglyceride, Bile acid, Chemistry, Fatty liver, FGF15/19, fibroblast growth factor 15/19, Cholesterol, WB, Western blot, ACC, Acetyl-CoA carboxylase, 030220 oncology & carcinogenesis, Lipogenesis, Quercetin, NAFLD, non-alcoholic fatty liver disease, medicine.medical_specialty, Bile acid metabolism, SDS, sodium dodecyl sulfate, TGR5, Takeda G-protein-coupled receptor 5, medicine.drug_class, Hyperoside, LC-MS, the combination of high-performance liquid chromatography and mass spectrometry, Article, Bile Acids and Salts, pACC, phosphorylated ACC, 03 medical and health sciences, Label-free proteomics, FXR, farnesoid X receptor, CYP27A1, sterol 27-hydroxylase, NAFLD, Internal medicine, medicine, Animals, Cholesterol metabolism, Liver X receptor, ComputingMethodologies_COMPUTERGRAPHICS, BAs, bile acids, SREBP1, sterol regulatory element-binding protein 1, Targeted metabolomics, Lipid Metabolism, CYP7A1, cholesterol 7α-hydroxylase, medicine.disease, Rats, TC, total cholesterol, QC, quality control, AMPK, AMP-activated protein kinase, 030104 developmental biology, Endocrinology, PMSF, phenylmethylsulfonyl fluoride, Apo, apolipoprotein, BSH, bile salt hydrolase, Farnesoid X receptor

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a2bd34a875a308c3012404fcb1667ccTest
https://doi.org/10.1016/j.jare.2021.06.001Test

المؤلفون: Hui Ao, Fei Tang, Jing Wang, Yu-Zhu Tan, Yan Wan, Lu Chen, Cheng Peng, Jin-feng Xu, Chao-long Rao

المصدر: Journal of Ginseng Research, Vol 45, Iss 6, Pp 617-630 (2021)
Journal of Ginseng Research

مصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, Ginsenosides, AMO, Atractylodes macrocephala volatile oil, PG, ERK, extracellular signal-regulated kinases, PPD, protopanaxadiol, CY, cyclophosphamide, Review Article, AST, aspartate aminotransferase, Pharmacology, TNF-α, tumor necrosis factor-α, MKK4, mitogen activated protein kinase kinase 4, NQO, NAD (P) H quinone oxidoreductase, PGLF, PG leaf, Ginseng, Pharmacological effects, 0302 clinical medicine, RGE, red ginseng extract, Medicine, PGS, PG total saponins, Side effects, HO-1, heme oxygenase-1, CK, compound K, CIA, chemotherapy-induced hair loss, Kinase, PGFR, PG flower, PI3K, phosphatidylinositol 3-kinase, PGSD, PG seeds, FRG, probiotic-fermented eRG, NF-κB, nuclear factor-kappa B p65, BMNC, bone marrow nucleated cells, RG, red ginseng, 030220 oncology & carcinogenesis, Nrf2, nuclear factor erythroid related factor 2, PG, Panax ginseng, Mechanism, KG-KH, the mixture of ginsenosides Rk3 and Rh4, Signal transduction, PGRT, PG root, Biotechnology, ADM, Adriamycin, CYP2E1, Cytochrome P450 E1, eRG, 50% ethanol-extracted RG, ARE, antioxidant response element, mTOR, mammalian target of rapamycin, HEI-OC1, House Ear Institute-Organ of Corti 1, ERG, enzyme-treated eRG, Biochemistry, Genetics and Molecular Biology (miscellaneous), LLC-PK1, porcine renal proximal epithelial tubular, 03 medical and health sciences, ROS, reactive oxygen species, ALT, alanine aminotransferase, DAC, doses of docetaxel, doxorubicin as well as cyclophosphamide, GM-CSF, granulocyte macrophage colony-stimulating factor, LSK, Lin−Sca-1+c-kit+, Chemotherapy, Protein kinase A, Protein kinase B, PI3K/AKT/mTOR pathway, MDA, malonaldehyde, Cardiotoxicity, SREBP-1, sterol regulatory element binding protein 1, HSPCS, haematopoietic stem and progenitor cells, business.industry, Botany, wRG, water-extracted RG, PPT, protopanaxatriol, PGSM, PG stem, FRGE, fermented red ginseng extract, IL, interleukin, CP, cisplatin, AMPK, AMP-activated protein kinase, 030104 developmental biology, Complementary and alternative medicine, FBG, fermented black ginseng, QK1-989, JNK, c-jun N-terminal kinase, 5-FU, 5-fluorouracil, business, MAPK, mitogen-activated protein kinase, MEK, mitogen activated protein kinase

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bddba476a926baf2ffce4db535797ce9Test
https://doi.org/10.1016/j.jgr.2021.03.001Test

المؤلفون: Liwu Fu, Hong Zhang

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 6, Pp 1400-1411 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: FANCD2, Fanconi anemia protein, DFS, disease-free survival, HNC, head and neck cancer, Cancer therapy, Review, medicine.disease_cause, SCC, squamous cell carcinoma, Metastasis, εPKC, epsilon protein kinase C, 0302 clinical medicine, NAD, nicotinamide adenine dinucleotide, Polymorphism (computer science), PdG, N2-propano-2′-deoxyguanosine, EC, esophageal cancer, General Pharmacology, Toxicology and Pharmaceutics, FA, Fanconi anemia, Cancer, TGF-β, transforming growth factor β, 0303 health sciences, Progression, GCA, gastric cancer, NRF2, nuclear factor erythroid 2 (NF-E2)-related factor 2, ccRCC, clear-cell renal cell carcinomas, NHEJ, non-homologous end-joining, PC, pancreatic cancer, 030220 oncology & carcinogenesis, CRC, colorectal cancer, NeG, 1,N2-etheno-dGuo, PBMC, peripheral blood mononuclear cell, ALD, alcoholic liver disease, CSCs, cancer stem cells, OvCa, ovarian cancer, COUP-TF, chicken ovalbumin upstream promoter-transcription factor, BCa, bladder cancer, NF-κB, nuclear factor-κB, Single-nucleotide polymorphism, Acetaldehyde, RM1-950, 4-HNE, 4-hydroxy-2-nonenal, OS, overall survival, 03 medical and health sciences, NSCLC, non-small-cell lung, medicine, SNP, MN, micronuclei, Polymorphism, ALDH2, 030304 developmental biology, LCSCs, liver cancer stem cells, MDA, malondialdehyde, business.industry, ALDH2, aldehyde dehydrogenase 2, MDR, multi-drug resistance, OPC, oropharyngeal cancer, HDACs, histone deacetylases, medicine.disease, AMPK, AMP-activated protein kinase, VHL, von Hippel-Lindau, Tumor progression, REV1, Y-family DNA polymerase, NER, nucleotide excision repair pathway, NRRE, nuclear receptor response element, Tumorigenesis, Cancer research, NCEs, normochromic erythrocytes, Therapeutics. Pharmacology, HR, homologous recombination, HCC, hepatocellular carcinoma, business, Carcinogenesis, HNF-4, hepatocyte nuclear factor 4

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dd88ae6dedbdf2435fcfad1324d1900Test
https://doi.org/10.1016/j.apsb.2021.02.008Test

المؤلفون: Heidi L. Weiss, B. Mark Evers, Jeremy Johnson, Zeta Chow, Piotr G. Rychahou, Eun Y. Lee

المصدر: Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 4, Pp 429-438 (2021)
Neoplasia (New York, N.Y.)

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, IHC, Immunohistochemistry, Lung Neoplasms, AKT1, AKT2, Apoptosis, Triple Negative Breast Neoplasms, Mice, SCID, AMP-Activated Protein Kinases, Mice, 0302 clinical medicine, Circulating tumor cell, Akt, Protein kinase B, Mice, Inbred NOD, PS, Pencillin-streptomycin, RPMI, Roswell Park Memorial Institute, Triple negative breast cancer, RNA, Small Interfering, Triple-negative breast cancer, AMPKα, Neoplastic Cells, Circulating, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, ER+, Estrogen receptor-positive, WB, Western blot, 030220 oncology & carcinogenesis, GFP, Green fluorescent protein, siRNA, Small interfering RNA, Female, RNA Interference, Signal transduction, TNBC, Triple negative breast cancer, Heterocyclic Compounds, 3-Ring, Signal Transduction, Original article, PBS, Phosphate buffered saline, Biology, lcsh:RC254-282, NSG, NOD-scid IL2Rgammanull, 03 medical and health sciences, Cell Line, Tumor, Animals, Humans, Neoplasm Invasiveness, Pyrroles, Protein kinase B, Akt, AMPK, Organ metastasis, AMPK, AMP-activated protein kinase, 030104 developmental biology, Pyrimidines, Cancer cell, Cancer research, FBS, Fetal bovine serum, Energy Metabolism, Proto-Oncogene Proteins c-akt

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f579366bddfd960dbbe114706d860b9Test
http://www.sciencedirect.com/science/article/pii/S1476558621000154Test

المؤلفون: Tanja Dominko, Pamela J. Weathers, David Dolivo

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 2, Pp 322-339 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: BUN, blood urea nitrogen, Artesunate, Review, Pharmacology, Col I, type I collagen, LAP, latency-associated peptide, chemistry.chemical_compound, 0302 clinical medicine, Scar, HUVEC, human umbilical vein endothelial cell, Fibrosis, CCl4, carbon tetrachloride, NAG, N-acetyl-β-d-glucosaminidase, General Pharmacology, Toxicology and Pharmaceutics, Artemisinin, HA, hyaluronic acid, 0303 health sciences, LDH, lactate dehydrogenase, LDH - Lactate dehydrogenase, mTOR, mechanistic target of rapamycin, TGF, β-transforming growth factor-β, DLA, dried leaf Artemisia, i.p., intraperitoneal, HSC, hepatic stellate cell, ALP - Alkaline phosphatase, DHA, dihydroartemisinin, ECM, extracellular matrix, MMP, matrix metalloproteinase, Alt alanine aminotransferase, 030220 oncology & carcinogenesis, MI, myocardial infarction, Fibroblast, TIMP, tissue inhibitor of metalloproteinase, medicine.drug, TGF-β, Anti fibrotic, ASP, aspartate aminotransferase, PCNA, proliferating cell nuclear antigen, BDL, bile duct ligation, FLS, fibroblast-like synoviocyte, STZ, streptozotocin, PHN, passive heymann nephritis, CTGF, connective tissue growth factor, 03 medical and health sciences, ROS, reactive oxygen species, ALT, alanine aminotransferase, parasitic diseases, medicine, BAD, BCL-2-associated agonist of cell death, sCr, serum creatinine, NICD, Notch intracellular domain, UUO, unilateral ureteral obstruction, 030304 developmental biology, Myofibroblast, ALP, alkaline phosphatase, business.industry, lcsh:RM1-950, medicine.disease, AMPK, AMP-activated protein kinase, lcsh:Therapeutics. Pharmacology, Artemisia, chemistry, Tissue fibrosis, BSA, bovine serum albumin, α-SMA, smooth muscle α-actin, business, EMT, epithelial-to-mesenchymal transition, MAPK, mitogen-activated protein kinase

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b31e277e49b3a3364e9726d531259ad4Test
https://doi.org/10.1016/j.apsb.2020.09.001Test

المؤلفون: Mohamed Abu el Maaty, Stefan Wölfl

المصدر: International Journal of Molecular Sciences; Volume 18; Issue 10; Pages: 2184

مصطلحات موضوعية: vitamin D, cancer, metabolism, autophagy, AMPK (AMP-activated protein kinase), mTOR (Mammalian target of rapamycin), TXNIP (Thioredoxin-interacting protein), p53, HIF1a (Hypoxia-inducible factor 1a), c-Myc

جغرافية الموضوع: agris

وصف الملف: application/pdf

العلاقة: Biochemistry; https://dx.doi.org/10.3390/ijms18102184Test

الإتاحة: https://doi.org/10.3390/ijms18102184Test

المؤلفون: Jian-Li Zhang, Ying Xu, Jie Shen

المصدر: International Journal of Molecular Sciences, Vol 15, Iss 7, Pp 12119-12134 (2014)

مصطلحات موضوعية: Kawasaki disease, cordycepin, TNFα (tumor necrosis factor α), AMPK (AMP-activated protein kinase), LPS (lipopolysaccharide), Biology (General), QH301-705.5, Chemistry, QD1-999

وصف الملف: electronic resource

العلاقة: http://www.mdpi.com/1422-0067/15/7/12119Test; https://doaj.org/toc/1422-0067Test

الوصول الحر: https://doaj.org/article/14e73416da16474fb7e630cd43f52646Test

المؤلفون: Zhi-Yuan Wu, Jin-Song Bian, Xiao-Wei Nie, Hai-Jian Sun, Xin-Yu Wang

المصدر: Journal of Advanced Research, Vol 27, Iss, Pp 127-135 (2021)
Journal of Advanced Research

مصطلحات موضوعية: 0301 basic medicine, Steatosis, STAT3, signal transducer and activator of transcription 3, Regulator, HO-1, heme oxygenase 1, SPRC, S-propargyl-cysteine, NaHS, sodium hydrosulfide, Liver disease, 0302 clinical medicine, HFD, high fat diet, PPG, propargylglycine, Fibrosis, MMP-2, matrix metalloproteinase 2, NF-κB, nuclear factor-kappa B, Cancer, lcsh:R5-920, Multidisciplinary, Hydrogen sulfide, CAT, cysteine aminotransferase, PI3K, phosphatidylinositol 3-kinase, CBS, cystathione β-synthase, FAS, fatty acid synthase, CSE, cystathione γ-lyase, DAO, D-amino acid oxidase, CO, carbon monoxide, COX-2, cyclooxygenase-2, 030220 oncology & carcinogenesis, NAFLD, non-alcoholic fatty liver diseases, AGTR1, angiotensin II type 1 receptor, CX3CR1, chemokine CX3C motif receptor 1, lcsh:Medicine (General), Liver cancer, NASH, nonalcoholic steatohepatitis, Nrf2, nuclear factor erythroid2-related factor 2, 3-MST, 3-mercaptopyruvate sulfurtransferase, Sulfurtransferase, mTOR, mammalian target of rapamycin, Article, SAC, S-allyl-cysteine, H2S, hydrogen sulfide, 03 medical and health sciences, VLDL, very low density lipoprotein, NADH, nicotinamide adenine dinucleotide, medicine, lcsh:Science (General), ComputingMethodologies_COMPUTERGRAPHICS, PTEN, phosphatase and tensin homolog deleted on chromosome ten, 3-MP, 3-mercaptopyruvate, business.industry, ERK, extracellular regulated protein kinases, IR, ischemia/reperfusion, NADPH, nicotinamide adenine dinucleotide phosphate, equipment and supplies, medicine.disease, EGFR, epidermal growth factor receptor, AMPK, AMP-activated protein kinase, 030104 developmental biology, Akt, protein kinase B, Cancer research, DATS, Diallyl trisulfide, PLP, pyridoxal 5′-phosphate, Hepatic fibrosis, business, lcsh:Q1-390

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea4f72879a610d4ef2b815d4fcf07fddTest
https://doi.org/10.1016/j.jare.2020.05.010Test