نتائج البحث

المساهمون: Laboratoire d'innovation moléculaire et applications (LIMA), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

المصدر: ISSN: 0968-0896.

مصطلحات موضوعية: aldose reductase (ALR2), interactive pocket, N-benzyl(oxotriazinoindole) ALR2 inhibitors, desolvation penalty, [CHIM]Chemical Sciences, [SDV]Life Sciences [q-bio]

العلاقة: hal-03070904; https://hal.archives-ouvertes.fr/hal-03070904Test; https://hal.archives-ouvertes.fr/hal-03070904/documentTest; https://hal.archives-ouvertes.fr/hal-03070904/file/01_Publication-STFK_LK.pdfTest

الإتاحة: https://hal.archives-ouvertes.fr/hal-03070904Test
https://hal.archives-ouvertes.fr/hal-03070904/documentTest
https://hal.archives-ouvertes.fr/hal-03070904/file/01_Publication-STFK_LK.pdfTest

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5

دورية أكاديمية

Thiazolidinediones : an in depth study of their synthesis and application to medicinal chemistry in the treatment of diabetes mellitus

المؤلفون: Long, Nathan, Le Gresley, Adam, Wren, Stephen

مصطلحات موضوعية: Biological sciences, Chemistry, diabetes mellitus, synthesis, thiazolidinediones, medicinal chemistry, minireview, minireviews, PPARγ, PTP1B, ALR2

وصف الملف: text

العلاقة: https://eprints.kingston.ac.uk/id/eprint/48921/3/Long-N-48921-VoR.pdfTest; Long, Nathan, Le Gresley, Adam and Wren, Stephen (2021) Thiazolidinediones : an in depth study of their synthesis and application to medicinal chemistry in the treatment of diabetes mellitus. ChemMedChem, 16(11), pp. 1717-1736. ISSN (print) 1860-7179

الإتاحة: https://doi.org/10.1002/cmdc.202100177Test
https://eprints.kingston.ac.uk/id/eprint/48921Test/
https://eprints.kingston.ac.uk/id/eprint/48921/3/Long-N-48921-VoR.pdfTest

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6

Thiazolidinediones: An In–Depth Study of Their Synthesis and Application to Medicinal Chemistry in the Treatment of Diabetes Mellitus

المؤلفون: Nathan Long, Adam Le Gresley, Stephen P. Wren

المصدر: Chemmedchem

مصطلحات موضوعية: PPARγ, endocrine system diseases, Chemistry, Pharmaceutical, Pharmacology, chemistry, 01 natural sciences, Biochemistry, Aldehyde Reductase, Diabetes mellitus, Drug Discovery, Diabetes Mellitus, medicine, Animals, Humans, Hypoglycemic Agents, General Pharmacology, Toxicology and Pharmaceutics, Receptor, Biological sciences, Protein Tyrosine Phosphatase, Non-Receptor Type 1, Aldose reductase, ALR2, 010405 organic chemistry, Chemistry, Organic Chemistry, PTP1B, nutritional and metabolic diseases, Minireviews, medicine.disease, Protein Tyrosine Phosphatase 1B, 0104 chemical sciences, PPAR gamma, 010404 medicinal & biomolecular chemistry, Molecular Medicine, Thiazolidinediones, Minireview, Pharmacophore, biological

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1414f8c86795d0a05cfedb80650f76b9Test
https://doi.org/10.1002/cmdc.202100177Test

7

دورية أكاديمية

N-(aroyl)-N-(arylmethyloxy)-α-alanines: selective inhibitors of aldose reductase

المؤلفون: NENCETTI, SUSANNA, LA MOTTA, CONCETTINA, ROSSELLO, ARMANDO, SARTINI, STEFANIA, NUTI, ELISA, Ciccone, Lidia, ORLANDINI, ELISABETTA

المساهمون: Nencetti, Susanna, LA MOTTA, Concettina, Rossello, Armando, Sartini, Stefania, Nuti, Elisa, Ciccone, Lidia, Orlandini, Elisabetta

مصطلحات موضوعية: Aldose reductase (ALR2), Aldose reductase selective inhibitor, Diabetes mellitu, α-Alanines

وصف الملف: ELETTRONICO

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/28392277; info:eu-repo/semantics/altIdentifier/wos/WOS:000402852600013; volume:25; issue:12; firstpage:3068; lastpage:3076; numberofpages:9; journal:BIOORGANIC & MEDICINAL CHEMISTRY; http://hdl.handle.net/11568/850492Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85017128780; https://www.sciencedirect.com/science/article/pii/S0968089616314808Test

الإتاحة: https://doi.org/10.1016/j.bmc.2017.03.056Test
http://hdl.handle.net/11568/850492Test
https://www.sciencedirect.com/science/article/pii/S0968089616314808Test

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8

Design and development of novel thiazole-sulfonamide derivatives as a protective agent against diabetic cataract in Wistar rats via inhibition of aldose reductase

المؤلفون: Mingxue Zhang, Tiangeng He, Liang Yin

المصدر: Heterocyclic Communications, Vol 27, Iss 1, Pp 63-70 (2021)

مصطلحات موضوعية: Aldose reductase, hybrid, diabetes, genetic structures, Chemistry, Organic Chemistry, Sulfonamide (medicine), compound synthesis, alr2, Pharmacology, medicine.disease, Diabetic cataract, chemistry.chemical_compound, QD241-441, cataract, Diabetes mellitus, medicine, sense organs, Thiazole, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89a181dc66e583310a6f5d2dc49ac711Test
https://doi.org/10.1515/hc-2020-0124Test

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Novel substituted N-benzyl(oxotriazinoindole) inhibitors of aldose reductase exploiting ALR2 unoccupied interactive pocket

المؤلفون: Gilles Hanquet, Gabriela Addová, Matúš Hlaváč, Marta Soltesova Prnova, Milan Stefek, Lucia Kovacikova, Andrej Boháč

المساهمون: Laboratoire d'innovation moléculaire et applications (LIMA), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Hanquet, Gilles

المصدر: Bioorganic and Medicinal Chemistry
Bioorganic and Medicinal Chemistry, Elsevier, 2020
Bioorganic and Medicinal Chemistry, Elsevier, 2021, 29, pp.115885. ⟨10.1016/j.bmc.2020.115885⟩

مصطلحات موضوعية: Male, Indoles, Stereochemistry, N-benzyl(oxotriazinoindole) ALR2 inhibitors, [SDV]Life Sciences [q-bio], Clinical Biochemistry, Pharmaceutical Science, 01 natural sciences, Biochemistry, chemistry.chemical_compound, Structure-Activity Relationship, desolvation penalty, Aldehyde Reductase, Drug Discovery, [CHIM] Chemical Sciences, Lens, Crystalline, Animals, [CHIM]Chemical Sciences, Desolvation, Enzyme Inhibitors, Rats, Wistar, Molecular Biology, ComputingMilieux_MISCELLANEOUS, chemistry.chemical_classification, Aldose reductase, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Triazines, aldose reductase (ALR2), Organic Chemistry, 0104 chemical sciences, Rats, [SDV] Life Sciences [q-bio], Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, Enzyme, chemistry, Molecular Medicine, interactive pocket, Selectivity, Lead compound

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e9864da0d8d175b47891ee35ec8f429Test
https://hal.archives-ouvertes.fr/hal-03070904/documentTest

10

دورية أكاديمية

Discovery anti-diabetic potent ofthiazolidinedione derivative based on virtual screening against aldose reducates

المؤلفون: Elhenawy, A.A., Abdel All, Mahmoud M., A. Alomri, Abd aziz

المصدر: JOURNAL OF ADVANCES IN CHEMISTRY; Vol. 10 No. 4 (2014); 2575-2584 ; 2321-807X

مصطلحات موضوعية: Antidibeatic, ADMET, ALR2 and Thiazolidinediones

وصف الملف: application/pdf

العلاقة: https://rajpub.com/index.php/jac/article/view/895/pdf_259Test; https://rajpub.com/index.php/jac/article/view/895Test

الإتاحة: https://doi.org/10.24297/jac.v10i4.895Test
https://rajpub.com/index.php/jac/article/view/895Test

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