المؤلفون: Xin-Qiu Yao, Donald Hamelberg

مصطلحات موضوعية: Biophysics, Genetics, Developmental Biology, Infectious Diseases, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, using human pin1, potential dynamic basis, combined effect determines, biomolecules requires separating, advanced statistical technique, final allosteric output, allosteric modulation using, catalyzed reaction rate, related conformational dynamics, allosteric systems, allosteric regulation, allosteric effector, reaction kinetics, reaction dynamics, reaction coordinate, various enzyme, prospective applications, pharmaceutical sciences, modulated allosterically, microscopic description, methods developed, largely missing

العلاقة: https://figshare.com/articles/journal_contribution/Dissecting_the_Allosteric_Fine-Tuning_of_Enzyme_Catalysis/25150813Test

الإتاحة: https://doi.org/10.1021/jacsau.3c00806.s001Test
https://figshare.com/articles/journal_contribution/Dissecting_the_Allosteric_Fine-Tuning_of_Enzyme_Catalysis/25150813Test

المؤلفون: Bay, Yasmin, Egeberg Jeppesen, Mie, Frydenvang, Karla, Francotte, Pierre, Pirotte, Bernard, Pickering, Darryl S., Kristensen, Anders Skov, Kastrup, Jette Sandholm

المصدر: Bay , Y , Egeberg Jeppesen , M , Frydenvang , K , Francotte , P , Pirotte , B , Pickering , D S , Kristensen , A S & Kastrup , J S 2024 , ' The positive allosteric modulator BPAM344 and L-glutamate introduce an active-like structure of the ligand-binding domain of GluK2 ' , FEBS Letters , vol. 598 , no. 7 , pp. 743-757 . https://doi.org/10.1002/1873-3468.14824Test

مصطلحات موضوعية: BPAM344 binding mode, calcium-sensitive fluorescence-based assay, dimer interface, GluK2 mutations, positive allosteric modulation, X-ray crystallography

وصف الملف: application/pdf

الإتاحة: https://doi.org/10.1002/1873-3468.14824Test
https://curis.ku.dk/portal/da/publications/the-positiveTest-allosteric-modulator-bpam344-and-lglutamate-introduce-an-activelike-structure-of-the-ligandbinding-domain-of-gluk2(edc0b943-651d-4436-ac37-82f7e06d37e7).html
https://curis.ku.dk/ws/files/387737935/FEBS_Letters_2024_Bay_The_positive_allosteric_modulator_BPAM344_and_L_glutamate_introduce_an_active_like_structure_of.pdfTest

المؤلفون: Romero-Fernandez, Wilber, Taura, Jaume J., Crans, Rene A. J., Lopez-Cano, Marc, Fores-Pons, Ramon, Narvaez, Manuel, Carlsson, Jens, Ciruela, Francisco, Fuxe, Kjell, Borroto-Escuela, Dasiel O.

المصدر: Molecular Neurobiology. 59(10):5955-5969

مصطلحات موضوعية: Adenosine A2A receptor, Dopamine D2 receptor, Metabotropic glutamate receptor 5, Heteroreceptor complex, Receptor-receptor interaction, Allosteric modulation

وصف الملف: electronic

الوصول الحر: https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-496019Test
https://doi.org/10.1007/s12035-022-02946-9Test
https://uu.diva-portal.org/smash/get/diva2:1734608/FULLTEXT01.pdfTest

المؤلفون: Kaczor, Agnieszka A., Wrobel, Tomasz M., Bartuzi, Damian

المصدر: Molecules. 28(1)

مصطلحات موضوعية: allosteric modulation, dopamine D-2 receptor, G protein-couple receptors, molecular modeling, drug synthesis

وصف الملف: electronic

الوصول الحر: https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-495638Test
https://doi.org/10.3390/molecules28010178Test
https://uu.diva-portal.org/smash/get/diva2:1732717/FULLTEXT01.pdfTest

المؤلفون: Hayley M. Green, Daniel M. J. Fellner, David B. Finlay, Daniel P. Furkert, Michelle Glass

المصدر: Pharmaceuticals, Vol 17, Iss 2, p 154 (2024)

مصطلحات موضوعية: Cannabinoid CB1 receptor, allosteric modulation, allosteric agonism, GAT229, GAT228, ZCZ011, Medicine, Pharmacy and materia medica, RS1-441

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/1424-8247/17/2/154Test; https://doaj.org/toc/1424-8247Test

الوصول الحر: https://doaj.org/article/3caa23ad45eb4c9bb86cba9efa8739a6Test

المؤلفون: Dmitry I. Osmakov, Lyudmila V. Onoprienko, Aleksandr P. Kalinovskii, Sergey G. Koshelev, Vasiliy N. Stepanenko, Yaroslav A. Andreev, Sergey A. Kozlov

المصدر: International Journal of Molecular Sciences, Vol 25, Iss 3, p 1413 (2024)

مصطلحات موضوعية: opioid peptide, acid-sensing ion channels, electrophysiology, positive allosteric modulation, ASIC pharmacology, analgesic peptide, Biology (General), QH301-705.5, Chemistry, QD1-999

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/1422-0067/25/3/1413Test; https://doaj.org/toc/1661-6596Test; https://doaj.org/toc/1422-0067Test

الوصول الحر: https://doaj.org/article/23f362f711884a8887f22259b01696ccTest

المؤلفون: Anh T. N. Nguyen, Quan L. Tran, Jo-Anne Baltos, Samantha M. McNeill, Diep T. N. Nguyen, Lauren T. May

المصدر: Frontiers in Endocrinology, Vol 14 (2023)

مصطلحات موضوعية: adenosine, A1 receptor, allosteric modulation, G protein-coupled receptor, structure-activity relationship, structure-function relationship, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fendo.2023.1184360/fullTest; https://doaj.org/toc/1664-2392Test

الوصول الحر: https://doaj.org/article/81d31d2e60944c6584c40e60fa79d4a9Test

المؤلفون: Victoria R. Sanders, Neil S. Millar

المصدر: Pharmacological Research, Vol 191, Iss , Pp 106759- (2023)

مصطلحات موضوعية: Acetylcholine receptor, Allosteric agonist, Allosteric modulation, Binding site, Nicotinic acetylcholine receptor, Positive allosteric modulator, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S1043661823001159Test; https://doaj.org/toc/1096-1186Test

الوصول الحر: https://doaj.org/article/318ad66499f947909440536d9ead5152Test

المؤلفون: Fan Guangchun, Tao Zhengxin, Chen Shang, Zhang Huahua, Yu Rongjie

المصدر: Acta Biochimica et Biophysica Sinica, Vol 54, Pp 657-672 (2022)

مصطلحات موضوعية: PACAP, PAC1-R, positive allosteric modulation, nuclear translocation, Biochemistry, QD415-436, Genetics, QH426-470

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1672-9145Test

الوصول الحر: https://doaj.org/article/0293c3fd22f14434a5f661ffabf67374Test

المؤلفون: Roger L. Papke, Marta Quadri, Alican Gulsevin

المصدر: Pharmacological Research, Vol 190, Iss , Pp 106736- (2023)

مصطلحات موضوعية: Nicotinic acetylcholine receptor, Inflammation, Signal transduction, Desensitization, Allosteric modulation, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S1043661823000920Test; https://doaj.org/toc/1096-1186Test

الوصول الحر: https://doaj.org/article/ff84c7fc09c649549e6b17ec2d68b6dfTest